Anti-aging protein klotho was associated with vitamin B12 concentration in adults

Abstract

Previous studies have reported that serum klotho and vitamin B12 levels are valuable aging-related markers. However, studies supporting the association between serum klotho and vitamin B12 levels are lacking. We investigated the association between serum klotho and vitamin B12 concentrations in adults in the United States. The analytic study sample was 2065 aged 40 to 79 who participated in the 2011 to 2014 National Health and Nutrition Examination Survey (NHANES). Serum klotho and vitamin B12 collected from adults who consented to the use of their samples in the future. The participants were divided into 2 groups based on estimated glomerular filtration rate (eGFR) levels (high: ≥90 mL/min/1.73 m2 or low: <90 mL/min/1.73 m2). Of the 2065 participants, the log-transformed klotho concentration was significantly correlated with log-transformed vitamin B12 in the high eGFR group, but not in the low eGFR group. After adjusting for all potential covariates, there was a significant association between klotho and vitamin B12 concentrations in the high eGFR groups (beta = 0.100, SE = 0.040). In contrast, there was no significant relationship between klotho and vitamin B12 concentrations in the low eGFR group (beta = 0.012, SE = 0.019). Serum klotho concentration was significantly associated with vitamin B12 increases in US adults with high kidney function. Vitamin B12 concentration may be an important marker of klotho concentration in older adults.

Association between anemia and serum Klotho in middle-aged and older adults

“…Besides, in an observational case-control study that included 40 thalassaemia patients and 41 healthy controls, there was no correlation between iFGF23 and Klotho concentrations and serum ferritin levels after controlling for age or BMI [ 18 ]. Interestingly, a current analysis of data obtained from the NHANES study found that increased serum Klotho concentrations were significantly associated with higher vitamin B12 concentrations [ 19 ]. Klotho may also increase the risk of anemia by affecting the reduction of anemia-related factors.…”

Association of Dietary Vitamin C Consumption with Serum Klotho Concentrations

“…A variety of functions can be performed by S-Klotho, like a hormone in cells and tissues that do not express Klotho, including inhibition of oxidative stress and inflammation [23]. ELISA-measured levels of S-Klotho have been established as a straightforward and significant marker of aging [24], thus finding widespread usage in population-based studies to investigate factors influencing aging-related diseases and their associations [16,25,26]. For this study, we sought to complement existing epidemiological research on the relationship between dietary vitamin C consumption and serum Klotho concentrations.…”

Food Supplements for Skin Health: In Vitro Efficacy of a Combination of Rhodiola rosea, Tribulus terrestris, Moringa oleifera and Undaria pinnatifida on UV-Induced Damage

“…The reduced bioavailability of vitamin B12 and folic acid metabolism impairment have also been demonstrated in aging [24][25][26] and supplementation with folates and B12 has been demonstrated to possess anti-aging effects in experimental models [27][28][29]. Other proposed treatments for treating aging-associated manifestations include metformin, stem cells and hyaluronic acid (either injected or topically applied), as well as other cosmetic and aesthetic procedures [30][31][32][33].…”