Anti-allergic and Anti-hyperglycemic Potentials of Lumnitzera racemose Leaves: In vivo and In silico Studies

Acharyya, Rabindra Nath; Mithila, Shuvra; Rani, Suborna; Islam, Md. Arman; Golder, Mimi; Ahmed, Khondoker Shahin; Hossain, Hemayet; Dev, Shrabanti; Das, Asish Kumar

doi:10.1007/s40011-022-01399-3

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…In silico docking study not only helps to predict the active site of a protein or enzyme but also helps to understand the binding mood of the compounds with the active site 36 . According to the molecular docking study among the eight compounds, docking score of chrysin, apigenin, kaempferol-3-O-beta-D-glucopyranoside, and stigmasterol were not significantly different from the standard drug cetirizine (-9.519 kcal/mol).…”

Section: Discussionmentioning

confidence: 99%

Antiallergic activity of Amoora cucullata Roxb bark extract and profiling of its polyphenolic compounds: In-vivo and in-silico studies

Mahmud,

Acharyya,

Paul

et al. 2023

Pharm Sci Asia

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Present study was undertaken to evaluate the anti-allergic activity of the ethanolic bark extract of Amoora cucullata (EBAC) in mice followed by molecular docking analysis and also to quantify the major bioactive polyphenolic constituents by HPLC analysis. Anti-allergic activity was evaluated using Toluene-2,4-diisocyanate (TDI)-sensitized allergy model mice by determining nasal allergy-like symptoms as well as counting the total and differential leukocytes profile of blood and Broncho Alveolar Lavage (BAL) fluid. In silico molecular docking study was performed using Schrödinger Maestro 10.1 on eight isolated compounds against Histamine Methyltransferase receptor in order to justify the anti-allergic activity of the extract. Acute toxicity test was performed to determine the safety of the extract. HPLC analysis exhibited the presence of 3,4-dihydroxy benzoic acid, catechol, (-) epicatechin, caffeic acid, syringic acid, rutin hydrate and trans-cinnamic acid. In anti-allergic activity test, oral administration of the EBAC improved nasal-allergic symptoms of TDI-induced allergic rhinitis in experimental mice. There was also a conspicuous decrease in the number of leukocytes, neutrophils, lymphocytes, eosinophils, monocytes and basophils in both blood and Broncho Alveolar Lavage (BAL) fluid of the mice treated with EBAC as compared to TDI-sensitized mice. Among the identified compounds from this plant, the docking score of Chrysin, Apigenin, Kaempferol-3-O-beta-D-glucopyranoside, and Stigmasterol against Histamine Methyltransferase receptor were comparable with that of standard drug Cetirizine (-9.519 kcal/mol). The EBAC did not exhibit any mortality in mice even at 3 gm/kg dose. The results of this study confirm the antiallergic activity of the plant in both in vivo and in silico investigations.

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Section: Discussionmentioning

confidence: 99%

Antiallergic activity of Amoora cucullata Roxb bark extract and profiling of its polyphenolic compounds: In-vivo and in-silico studies

Mahmud,

Acharyya,

Paul

et al. 2023

Pharm Sci Asia

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“…Mangrove is a wetland woody plant community composed of evergreen trees or shrubs mainly composed of mangrove plants growing in the intertidal zone of tropical and subtropical coasts. Acharyya et al [ 46 ] studied the anti-allergic activity of the Ethanol extract of Lumnitzera racemosa and the polyphenols related to this activity ( 16 – 24 , see Figure 1 ). Oral administration of the ethanol extract of L. racemosa significantly reduced the number of sneezes, scratches, and nasal pain, as well as the number of lymphocytes, neutrophils, and eosinophils, and significantly inhibited TDI-induced allergic symptoms.…”

Section: Chemical Structures and Biological Properties Of The Anti-al...mentioning

confidence: 99%

Structures and Anti-Allergic Activities of Natural Products from Marine Organisms

et al. 2023

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In recent years, allergic diseases have occurred frequently, affecting more than 20% of the global population. The current first-line treatment of anti-allergic drugs mainly includes topical corticosteroids, as well as adjuvant treatment of antihistamine drugs, which have adverse side effects and drug resistance after long-term use. Therefore, it is essential to find alternative anti-allergic agents from natural products. High pressure, low temperature, and low/lack of light lead to highly functionalized and diverse functional natural products in the marine environment. This review summarizes the information on anti-allergic secondary metabolites with a variety of chemical structures such as polyphenols, alkaloids, terpenoids, steroids, and peptides, obtained mainly from fungi, bacteria, macroalgae, sponges, mollusks, and fish. Molecular docking simulation is applied by MOE to further reveal the potential mechanism for some representative marine anti-allergic natural products to target the H1 receptor. This review may not only provide insight into information about the structures and anti-allergic activities of natural products from marine organisms but also provides a valuable reference for marine natural products with immunomodulatory activities.

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Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies

Dey,

Rani,

Acharyya

et al. 2025

Phytomedicine Plus

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Anti-allergic and Anti-hyperglycemic Potentials of Lumnitzera racemose Leaves: In vivo and In silico Studies

Cited by 4 publications

References 25 publications

Antiallergic activity of Amoora cucullata Roxb bark extract and profiling of its polyphenolic compounds: In-vivo and in-silico studies

Antiallergic activity of Amoora cucullata Roxb bark extract and profiling of its polyphenolic compounds: In-vivo and in-silico studies

Structures and Anti-Allergic Activities of Natural Products from Marine Organisms

Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies

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