Anti-Allergic Effect of a Hot-Water Extract of Quince (<i>Cydonia oblonga</i>)

Shinomiya, Fumie; Hamauzu, Yasunori; Kawahara, Teppei

doi:10.1271/bbb.90130

Cited by 61 publications

(33 citation statements)

References 41 publications

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“…Quince HW was prepared as described previously (Shinomiya et al 2009). In brief, the peel, pulp and seeds of quince fruits were cut into pieces, and then boiled in hot water for 1 h. After filtering the extract through a layer of cloth, the filtrate was centrifuged at 5,0009g for 30 min.…”

Section: Preparation Of Quince Hwmentioning

confidence: 99%

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Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells

Kawahara

Iizuka

2011

Cytotechnology

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We evaluated the effect of a crude hot-water extract (HW) of quince (Cydonia oblonga Miller) fruit on immunoglobulin E (IgE)-dependent late-phase immune reactions of mast cells using in vitro system. Mast cell-like RBL-2H3 cells were treated with quince HW and late-phase reaction was then induced by stimulation with IgE + Antigen. Quince HW reduced the elevation of interleukin-13 and tumor necrosis factor-α expression level. Furthermore, quince HW suppressed these cytokine expressions of mouse bone marrow-derived mast cells (BMMCs), a normal mast cell model. Leukotriene C(4) and prostaglandin D(2) production in BMMCs after 1 and 6 h of stimulation, respectively, were also reduced by treating the cells with quince HW. We found that the induction of intracellular cyclooxygenase (COX)-2 expression but not COX-1 expression in BMMCs was reduced by quince HW. These results suggest that quince HW has an inhibitory effect on broad range of the late-phase immune reactions of mast cells.

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Section: Preparation Of Quince Hwmentioning

confidence: 99%

“…Recently, we reported the anti-allergic effect of a crude hot-water extract (HW) of quince on immediate allergic model NC/Nga mice (Shinomiya et al 2009). Quince HW notably alleviated the severity of atopic dermatitis-like skin lesions with degranulation of serum IgE.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells

Kawahara

Iizuka

2011

Cytotechnology

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“…In addition, the stimulatory activity toward bifidobacterial release assay was employed to evaluate IgE-mediated degranulation in this study (Kobayashi and Tanabe, 2006;Shinomiya et al, 2009). RBL-2H3 cells (2 × 10 5 cells/well)…”

Section: Resultsmentioning

confidence: 99%

Allergy-suppressing Activity of Oligosaccharides in Sweet Potato-Shochu Distillery By-product

Yonemoto

Nakano²,

Kawahara

et al. 2013

FSTR

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We obtained anti-allergic oligosaccharides from a sweet potato-shochu distillery by-product (SDB).Oral administration of oligosaccharides A and B in SDB to ovalbumin/aluminum-sensitized mice for 4 weeks resulted in a significant decrease in serum IgE concentration. The release of β-hexosaminidase from rat basophilic leukemia cell line RBL-2H3 was also suppressed by the addition of oligosaccharides A and B to the cell culture. The molecular weights of oligosaccharides A and B were about 730 and 530, respectively, determined from the retention time on Bio-Gel P-2. Oligosaccharide A was composed of galactose, glucose and uronic acid in a molar ratio of 2:1:1. Oligosaccharide B was composed of galactose, glucose and arabinose (1:1:1 molar ratio) or galactose, glucose and uronic acid (1:1:1 molar ratio), showing that oligosaccharide B is a heterogeneous mixture of other oligosaccharides. Oligosaccharides A and B exhibited growth-stimulating activity with Bifidobacterium lactis BB-12. The present results indicate that the oligosaccharides in SDB are promising ingredients for the effective control of allergic diseases via suppression of IgE production and inhibition of basophilic leukemia cells degranulation.Keywords: anti-allergy, shochu by-product, oligosaccharide, suppression of IgE production, suppression of β-hexosaminidase release, Bifidobacterium growth stimulation *To whom correspondence should be addressed. E-mail: t.yonemoto@satsuma.co.jp IntroductionShochu is a traditional alcohol spirit in the south of Japan. After alcoholic fermentation of sweet potato with rice Koji and yeast, the alcohol and other volatile components were distilled. Sweet potato-shochu distillery by-product (SDB) contains numerous components originating from its raw materials, rice malt and yeast, and is rich in nutrients, including oligosaccharides, peptides, dietary fiber, polyphenols and vitamins. There are many reports on the functions of SDB,

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“…PG102, an aqueous extract from Actinidia arguta (26), is an example exhibiting such an activity. White rose fetal extract of Rosa rugosa root (27), procyanidin C1 from apple (28), and hot water extract of Cydonia oblonga (29) have shown potential in inhibiting chemical-induced animal model or NC/Nga mice. In the course of screening of anti-atopic agents, we found that an aqueous TcRSE exhibits in vitro antioxidant and free radical-scavenging capability, and has potent T-bet promoter enhancing activity.…”

Section: Discussionmentioning

confidence: 99%

Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius

Lee¹

2011

Int J Mol Med

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Abstract.To evaluate whether an aqueous seed extract of Terminalia chebula Retzius inhibited development of atopy in vivo, we used a 2,4-dinitrofluorobenzene (DNFB)-induced animal model of atopic symptoms to investigate the effects of the extract. We measured CD4 + cell numbers by hematoxylin and eosin (H&E) staining, and determined the expression levels of matrix metalloproteinase (MMP)-9, interleukin (IL)-31, and T-bet genes, in this animal model. The data showed that a Terminalia chebula extract (100 µg/ml) exhibited strong anti-atopic activity, mediating a 52% reduction in the immune response, as measured by thickness of ear swelling, and resulting in decreased eosinophil levels in adjacent skin tissue. Collectively, the results indicate that a Terminalia chebula seed extract has potential for alleviation of atopy-like symptoms induced by DNFB in the mouse. IntroductionIt is generally accepted that the daily consumption of plantderived phytochemicals in vegetables, fruit, tea or herbal extracts may mitigate free-radical attacks (1-3). Terminalia chebula Retzius is an ethnopharmacological plant of India and Southeast Asia, and has traditionally been used as a laxative, a diuretic, and an anti-oxidative material (4-8). In addition, plant extracts have antibacterial (9,10), antiviral (11), antifungal (12) and immune modulatory activities (13,14). Recently, Lee et al (5,15) reported that an aqueous seed extract of Terminalia chebula Retzius (TcRSE) had potent anti-oxidant activity both in vitro and in vivo when tested as a hepatoprotective agent in an animal model. Atopic dermatitis is a major degenerative disease, which presents as a chronic inflammatory skin condition with a deficiency in barrier function (16). It is now well recognized that several proteases, including the matrix metalloproteinases (MMPs), play key roles in the immunopathology of and biological functions during progression of the disease (17). With limited exceptions, normal healthy skin does not contain or exhibit high levels of MMP activity. Thus, evaluation of enzyme activities is important in detection, prior to mitigation, of allergic reactions (18,19). However, little effort has been devoted to treatment of atopy-related disorders with natural extracts, and we thus prioritized the investigation of TcRSE as an inhibitor of anti-atopic dermatitis activity.In the present study, we initially sought immunomodulatory components in natural resources including foods and oriental herbs, and found that TcRSE was active in vitro (data not shown). We thus examined the ameliorating effects of TcRSE against 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis in mice. Biochemical and immunochemical analyses, including cytokine expression evaluation and phenotypic atopic symptoms, were performed to investigate whether TcRSE alleviated the disorder. Materials and methodsChemicals. MMP-9, anti-T-bet and interleukin (IL)-31 antiinterleukin (IL)-31 anti-IL)-31 antibodies were purchased from Cell Signaling (catalog no. 3852; Danvers, MA), Santa Cruz ...

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Anti-Allergic Effect of a Hot-Water Extract of Quince (Cydonia oblonga)

Cited by 61 publications

References 41 publications

Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells

Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells

Allergy-suppressing Activity of Oligosaccharides in Sweet Potato-Shochu Distillery By-product

Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius

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