Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice

Medeiros, Karina C.P.; Figueiredo, Camila A.; Figueredo, T.B.; Freire, Kristerson R. L.; Santos, Francisco de Assis Ribeiro dos; Alcântara-Neves, Neuza Maria; Silva, T.M.S.; Piuvezam, Márcia Regina

doi:10.1016/j.jep.2008.05.036

Cited by 93 publications

(58 citation statements)

References 36 publications

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“…Recently, it was reported that essential functional groups of flavonoids to confer good NA inhibitory effects are hydroxyl groups in positions 4′ and 7, an oxo group in position 4, and a double bond between positions 2 and 3, showing agreement with our results [4]. The antiviral activities of compounds 1-7 against the influenza A virus were determined using the CPE reduction assay in MDCK cells to evaluate the cytotoxicity and to confirm the anti-influenza activity (l " Table 1).…”

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confidence: 92%

Characterization of Neuraminidase Inhibitors in Korean Papaver rhoeas Bee Pollen Contributing to Anti-Influenza Activities In Vitro

et al. 2016

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Bee pollen is a granule-type material of agglutinated flower pollen made by worker honey bees with nectar and bee secretions. The resulting pollen is higher in nutritional value than untreated pollen, and is used as the primary source of protein for the bee hive. Bee pollen has been used in folk medicine from ancient times in many regions of the world for its medical properties to alleviate or cure conditions such as colds, flu, ulcers, and anemia [1]. Recently, biological effects such as antiox- [7], and antimutagenic [8] activities were also reported. Like other apicultural products, royal jelly, honey, and propolis, the chemical composition of bee pollen depends on the plant source, regional vegetation, season, and honeybee races at the site of collection. It is rich in carbohydrates, proteins, lipids, minerals, vitamins, and various organic compounds, including phenolic acids and flavonoids. Most flavonoids from bee pollen exist as glycosides and contain kaempferol or quercetin as aglycone parts. Other phenolic acids usually found in Abstract !The active constituents of Korean Papaver rhoeas bee pollen conferring neuraminidase inhibitory activities (H1N1, H3N2, and H5N1) were investigated. Six flavonoids and one alkaloid were isolated and characterized by nuclear magnetic resonance and mass spectrometry data. These included kaempferol-3-sophoroside (1), kaempferol-3-neohesperidoside (2), kaempferol-3-sambubioside (3), kaempferol-3-glucoside (4), quercetin-3-sophoroside (5), luteolin (6), and chelianthifoline (7). All compounds showed neuraminidase inhibitory activities with IC 50 values ranging from 10.7 to 151.1 µM. The most potent neuraminidase inhibitor was luteolin, which was the dominant content in the ethyl acetate fraction. All tested compounds displayed noncompetitive inhibition of H3N2 neuraminidase. Furthermore, compounds 1-7 all reduced the severity of virally induced cytopathic effects as determined by the Madin-Darby canine kidney cell-based assay showing antiviral activity with IC 50 values ranging from 10.7 to 33.4 µM (zanamivir: 58.3 µM). The active compounds were quantified by highperformance liquid chromatography, and the total amount of compounds 1-7 made up about 0.592 g/100 g bee pollen, contributing a rich resource of a natural antiviral product. Abbreviations

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confidence: 92%

Characterization of Neuraminidase Inhibitors in Korean Papaver rhoeas Bee Pollen Contributing to Anti-Influenza Activities In Vitro

et al. 2016

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“…Other than propolis, an anti-inflammatory activity can be provided by bee pollen, such as that reported in the ethanol extract of pollen from A. mellifera in Brazil (Medeiros et al, 2008). The main active compounds were found to be phenolic compounds and furthermore these were similar to those found in various plants, such as berry ,vegetables, fruits and tea leaves.…”

Section: Anti-inflammatory Activitymentioning

confidence: 67%

Bee Diversity in Thailand and the Applications of Bee Products

Rattanawannee¹,

Chanchao²

2011

Changing Diversity in Changing Environment

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“…It decreases the allergic reaction by inhibiting ovalbumin specific antibodies (IgE and IgG 1 ) and further decreases total number of cells as well as number of eosinophils in bronchoalveolar lavage. Probably the most important anti-allergic component of bee pollen is myricetin, a flavonoid that represents about 2% of BPPE [14]. Ishikawa et al found out that daily ingestion of bee pollen by mice reduced IgE mediated activation of cutaneous mast cells.…”

Section: Can Bee Pollen Be Anti-allergic?mentioning

confidence: 99%

Bee pollen in allergy and immunology. Short review

et al. 2017

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S u m m a r yBee pollen is a natural resource -pollen collected by bees and stored in the beehive with various bee enzymes added as it is a mixture of plants pollen and bee saliva. It is rich source of various nutrients, among them exogenous amino acids. Therefore, it can be a good and natural dietary supplement. New possibilities for bee pollen usage arise every day, yet it can also be a threat. Although bee pollen can act as an immunostimulant and anti-allergic agent, it is also and maybe even primarily allergic or cross-reactive with many allergens. A number of bee pollen allergy cases was described worldwide. A caution is therefore needed before ingestion or any other form of administration, especially in case of children or individuals with atopic predispositions. Anti-allergic attributes and immunostimmulation ability still need further research. key words: bee pollen, bee pollen allergy, bee pollen immunology Bee pollen -what is it exactly?Bee pollen is a natural resource -a pollen collected by bees and stored in the beehive with various bee enzymes added as it is a mixture of plants pollen and bee saliva. Its chemical compositions varies, depending on the plant source, but it has been proved to contain about 250 different chemical substancesamino acids, vitamins, micro-and macroelements, carbohydrates, nucleic acids, triglycerides, phospholipids, flavonoids [1,2]. About 20% of bee pollen is

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Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice

Cited by 93 publications

References 36 publications

Characterization of Neuraminidase Inhibitors in Korean Papaver rhoeas Bee Pollen Contributing to Anti-Influenza Activities In Vitro

Characterization of Neuraminidase Inhibitors in Korean Papaver rhoeas Bee Pollen Contributing to Anti-Influenza Activities In Vitro

Bee Diversity in Thailand and the Applications of Bee Products

Bee pollen in allergy and immunology. Short review

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