Anti-allergic effects of vitamin E in allergic diseases: An updated review

Shams, Mohammad-Hossein; Jafari, Reza; Eskandari, Nahid; Masjedi, Mohsen; Kheirandish, Farnaz; Ganjalikhani‐Hakemi, Mazdak; Ghasemi, Ramin; Varzi, Ali-Mohammad; Sohrabi, Seyyed-Mohsen; Baharvand, Peyman Amanolahi; Safari, Mozhgan

doi:10.1016/j.intimp.2020.107196

Cited by 15 publications

(14 citation statements)

References 73 publications

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“…13 By contrast, in term of the serum level of IgE, administration of vitamin E to patients did not show any change compared to those without a given vitamin E supplement. 13 All addressing to claim that a low serum level of vitamin E may be associated with pathogenesis of allergic rhinitis are premature.…”

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confidence: 85%

“…In fact, the relationship between vitamin E and allergic rhinitis has been extensively reviewed recently. 13 Patients with allergic rhinitis who were treated with vitamin E showed an inconstant finding about the allergic rhinitisrelated symptoms or signs compared to those without vitamin E treatment. 13 The laboratory data are also in agreement with the aforementioned inconstant clinical findings, which allergic rhinitis-related biomarkers may not be always different between patients with or without administration of vitamin E. 13 In term of local effects or systemic effects, the data also failed to be consistent.…”

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confidence: 97%

“…13 Patients with allergic rhinitis who were treated with vitamin E showed an inconstant finding about the allergic rhinitisrelated symptoms or signs compared to those without vitamin E treatment. 13 The laboratory data are also in agreement with the aforementioned inconstant clinical findings, which allergic rhinitis-related biomarkers may not be always different between patients with or without administration of vitamin E. 13 In term of local effects or systemic effects, the data also failed to be consistent. For example, the inflammatory responses and the number of mucosal eosinophils were found to be reduced in rats treated with vitamin E compared to those without.…”

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confidence: 97%

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Is the lower serum level of vitamin E associated with pregnant women with allergic rhinitis?

Lee

Wang

2021

Journal of the Chinese Medical Association

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confidence: 97%

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Is the lower serum level of vitamin E associated with pregnant women with allergic rhinitis?

Lee

Wang

2021

Journal of the Chinese Medical Association

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“…Liposoluble vitamins β-carotene (pro-vitamin A) and tocopherol (vitamin E), obtained only from fresh vegetables and nuts, have also proven their protective effects against allergy due to their strong antioxidant properties. Vitamin E impairs Th2 inflammation on mice models, inhibiting eosinophil and neutrophil activation and the production of oxygen reactive species ( 142 ). Intranasal administration of tocopherol is a current approach to ameliorate symptoms in allergic rhinitis patients, but oral supplementation is not proven to be efficient in AD, FA or asthma treatment ( 143 ).…”

Section: Diet Modulates Epithelial Integrity: Protective and Harmful ...mentioning

confidence: 99%

Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality

et al. 2023

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The “epithelial barrier hypothesis” states that a barrier dysfunction can result in allergy development due to tolerance breakdown. This barrier alteration may come from the direct contact of epithelial and immune cells with the allergens, and indirectly, through deleterious effects caused by environmental changes triggered by industrialization, pollution, and changes in the lifestyle. Apart from their protective role, epithelial cells can respond to external factors secreting IL-25 IL-33, and TSLP, provoking the activation of ILC2 cells and a Th2-biased response. Several environmental agents that influence epithelial barrier function, such as allergenic proteases, food additives or certain xenobiotics are reviewed in this paper. In addition, dietary factors that influence the allergenic response in a positive or negative way will be also described here. Finally, we discuss how the gut microbiota, its composition, and microbe-derived metabolites, such as short-chain fatty acids, alter not only the gut but also the integrity of distant epithelial barriers, focusing this review on the gut-lung axis.

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“…Vitamin E is one of the most prominent dietary antioxidants and a free radical scavenger [ 2 ], and recently, has been reported to have anti-inflammatory, biochemical, and biomolecular activities [ 2 5 ]. As a result, vitamin E is considered to play important roles in the prevention of chronic diseases such as cardiovascular diseases, cancers, and allergic diseases, and growing evidence suggests that high intakes of vitamin E may lower risks of chronic diseases [ 2 5 6 7 8 9 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary intake and major source foods of vitamin E among Koreans: findings of the Korea National Health and Nutrition Examination Survey 2016–2019

et al. 2022

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BACKGROUND/OBJECTIVES Vitamin E is essential for health, and although vitamin E deficiency seems rare in humans, studies on estimates of dietary intake are lacking. This study aimed to estimate dietary vitamin E intake, evaluate dietary adequacy of vitamin E, and detail major food sources of vitamin E in the Korean population. SUBJECTS/METHODS This study used data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2019. Individuals aged ≥ 1 year that participated in a nutrition survey (n = 28,418) were included. Dietary intake was assessed by 24-h recall and individual dietary vitamin E intake was estimated using a newly established vitamin E database. Dietary adequacy was evaluated by comparing dietary intake with adequate intake (AI) as defined by Korean Dietary Reference Intakes 2020. RESULTS For all study subjects, mean daily total vitamin E intake was 7.00 mg α-tocopherol equivalents, which was 61.6% of AI. The proportion of individuals that consumed vitamin E at above the AI was 12.9%. Inadequate intake was observed more in females, older individuals, rural residents, and those with a low income. Mean daily intakes of tocopherol (α-, β-, γ-, and δ-forms) and tocotrienol were 6.02, 0.30, 6.19, 1.63, and 1.61 mg, respectively. The major food groups that contributed to total dietary vitamin E intake were grains (22.3%), seasonings (17.0%), vegetables (15.3%), and fish, and shellfish (7.4%). The top 5 individual food items that contributed to total vitamin E intake were baechu kimchi, red pepper powder, eggs, soybean oil, and rice. CONCLUSIONS This study shows that mean dietary vitamin E intake by Koreans did not meet the reference adequate intake value. To better understand the status of vitamin E intake, further research is needed that considers intake from dietary supplements.

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Anti-allergic effects of vitamin E in allergic diseases: An updated review

Cited by 15 publications

References 73 publications

Is the lower serum level of vitamin E associated with pregnant women with allergic rhinitis?

Is the lower serum level of vitamin E associated with pregnant women with allergic rhinitis?

Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality

Dietary intake and major source foods of vitamin E among Koreans: findings of the Korea National Health and Nutrition Examination Survey 2016–2019

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