2014
DOI: 10.1111/1346-8138.12578
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Anti‐allergic mechanisms of Japanese herbal medicine, yokukansan on mast cells

Abstract: We previously reported that the addition of orally administered yokukansan (YKS), a traditional Japanese herbal medicine, to the standard regimen using histamine H1-receptor inhibitors was effective in controlling refractory chronic urticaria, but the mechanism remained unknown. YKS has also been reported to be effective on inhibiting the development of atopic dermatitis-like skin lesions in NC/Nga mice. As known, the release of various chemical mediators including histamine from degranulated mast cells is str… Show more

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Cited by 9 publications
(4 citation statements)
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“…Yamamura et al (2014) also reported that YKS inhibited mast cell degranulation, TNFα release from mast cell-like RBL-2H3 basophil leukemia cells, and TNFα-induced intercellular adhesion molecule-1 expression in human endothelial cells. These ameliorative effects were not the actions on central nervous system, but were thought to be indirectly mediated by the psychopharmacological effects of YKS such as the anxiolytic effect (Yamamura et al, 2014). …”
Section: Psychopharmacological Effects Of Yksmentioning
confidence: 89%
“…Yamamura et al (2014) also reported that YKS inhibited mast cell degranulation, TNFα release from mast cell-like RBL-2H3 basophil leukemia cells, and TNFα-induced intercellular adhesion molecule-1 expression in human endothelial cells. These ameliorative effects were not the actions on central nervous system, but were thought to be indirectly mediated by the psychopharmacological effects of YKS such as the anxiolytic effect (Yamamura et al, 2014). …”
Section: Psychopharmacological Effects Of Yksmentioning
confidence: 89%
“…For instance, IL-6 inhibits the anticancer response by dampening the IL27/STAT1 signalling pathway [51]. IL-8 is mainly responsible for the recruitment of neutrophils, basophils and T cells [52, 53]. Moreover, accumulated evidence has revealed that IL-8 promotes angiogenesis and metastasis in tumour cells [54].…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, Z. rhizoma might be the key medical herb in EJT that reduces the expression of IL-4. Among 6 medical herbs in EJT, A. lanceae rhizoma was shown to inhibit β-hexosaminidase release from mast cell-like rat basophil leukemia cells [34]. Thus, A. lanceae rhizoma might be the major medical herb to suppress plasma mMcpt1 levels in our study.…”
Section: Discussionmentioning
confidence: 62%