Anti-Allergic Properties of a Matured Fruit Extract of the Date Palm Tree (Phoenix dactylifera L.) in Mite-Sensitized Mice

Karasawa, Koji; Otani, Hajime

doi:10.3177/jnsv.58.272

Cited by 21 publications

(15 citation statements)

References 18 publications

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“…A number of in vitro and in vivo studies have been performed to substantiate their use in folk medicine [1,2]. Date extracts were shown to possess a myriad of pharmacological properties such as antioxidant [3], anti-inflammatory [4], antiatherogenic [5], hepatoprotective [6], anticancer [6], nephroprotective [7], antimicrobial [8], antiallergic [9], immunostimulatory [10], neuroprotective [11], antifungal [12], antimutagenic [13] and gastrointestinal transition stimulatory activity [14]. Date supplementation was shown to be beneficial in Alzheimer's disease transgenic mice model [15].…”

Section: Introductionmentioning

confidence: 99%

Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats

et al. 2020

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Background: Consumption of plant-derived nutraceuticals and crude drugs in Arab traditional medicine is widely believed to confer beneficial effects in liver and kidney diseases. Fruits from the date palm Phoenix dactylifera L. are a rich source of nutrients and bioactive phytochemicals which possess a myriad of pharmacological effects. Herein, we examined the impact of Date Palm Pollen (DPP) aqueous suspension treatment on paracetamol (APAP) [Acetaminophen (APAP)] triggered hepatorenal damage in rats and further explored the underlying putative mechanism. Methods: Thirty Wistar rats were assigned to five groups (n = 6/group). Group I was control group; animals in group II were administered APAP 1000 mg/kg body weight (b.w.) intraperitonealy (i.p.); Group III and IV administered APAP plus date palm pollen with doses of 50, 100 mg/kg b.w and group V were administered APAP plus Silymarin (SIL) 10 mg/kg b.w. (i.p) respectively. Various biochemical parameters and histological assessment were evaluated in serum and tissue homogenate. Results: Pretreatment with DPP aqueous suspensions (50 and 100 mg/kg b.w.) significantly (p < 0.05) thwarted APAP triggered alterations in serum biomarkers of liver damage [aspartate transaminase (AST), alanine aminotransferase (ALT), γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP)], serum albumin as well as bilirubin. DPP treatment further mitigated APAP triggered dyslipidemia associated with hepatic damage by influencing APAP elicited changes in serum levels of cholesterol, triglycerides, HDL, LDL and VLDL. DPP treatment significantly (p < 0.05) ameliorated extrahepatic manifestations of APAP toxicity by influencing alterations in parameters of renal function (creatinine, urea and uric acid) as well serum electrolytes (Sodium, Potassium and Calcium). DPP treatment further influenced APAP-induced histological lesions by curtailing necrosis and inflammatory changes in the hepatic and renal architecture, respectively. Furthermore, DPP treatment modulated APAP-induced redox imbalance in the hepatic and renal tissue by blunting the increase of malondialdehyde (MDA) as well as decrease of nonprotein sulfhydryls (NP-SH) significantly (p < 0.05) when compared with control. The protective effect of DPP was further confirmed histologically. Conclusions: The present observations point to an hepatorenal protective effects of acute DPP treatment in APAP-intoxicated rats which is underpinned by its robust antioxidant properties.

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Section: Introductionmentioning

confidence: 99%

Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats

et al. 2020

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“…The phenolic content and antioxidant capacity of date fruits from the Middle Eastern countries have been studied extensively, mainly focusing on dates grown in Oman (Al‐Farsi and others ; Benmeddour and others ), Algeria (Mansouri and others ), Saudi Arabia (Awad and others ), and Iran (Biglari and others ). Various other functional properties of date fruit extracts have been investigated, including antimutagenic properties (Vayalil ), neuroprotective properties (Zangiabadi and others ), anti‐allergic effects (Karasawa and Otani ), cellular immune stimulation (Karasawa and others ), antidiabetic effect (Michael and others ), and protection from oxidative stress in rat liver (Saafi and others ) using in vivo and in vitro studies. Kader and Hussein () reported that dates were the only fruits that contain detectable amounts of flavonoid sulfates at the mature stages, while high amounts of procyanidin or condensed tannin were detected at the Khalal stage (Kader and Hussein ).…”

Section: Introductionmentioning

confidence: 99%

The Emerging Australian Date Palm Industry: Date Fruit Nutritional and Bioactive Compounds and Valuable Processing By‐Products

Sirisena

Ajlouni

2015

Comp Rev Food Sci Food Safe

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Date palm is a popular and high-revenue crop, and the consumption of date fruits is no longer limited to the Middle Eastern countries. Date fruit has gained interest due to its nutritional value and taste, and date seeds have recently been identified as sources of valuable bioactive ingredients. Australia has excellent agronomic conditions for cultivating date palm, and the value of this crop has been identified by the Australian government and private sectors. However, more work needs to be done to raise awareness of this industry among potential investors and researchers in order to develop a sustainable date palm industry in Australia. Several date varieties have been successfully grown at a small scale in Central and Southern Australia. Medjool and Barhee have been among the most recommended varieties due to their high market potential in domestic and international markets. Date seeds have also been recognized as a source of valuable functional ingredients including dietary fiber and natural antioxidants. Date seed extracts have shown very good bioactive properties potentially useful in treating some neurodegenerative diseases, and possibly cancer. The utilization of date seeds, which is an abundant by-product of date processing, could improve profitability and financial security of this industry. This review discusses the emergence of the date fruit and seed industry in Australia and its associated benefits to farmers and consumers.

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“…This study used [20] males from mature white rabbits distributed to [4] groups, each group included [5] animals with close weights: This group was given intraperitoneal injections of doxorubicin were given (10 mg/kg) once a week and an orally administered suspension of DPP date palm pollen (60 mg/kg) every day for four weeks.…”

Section: Experiments Designmentioning

confidence: 99%

“…To prove their usage in traditional medicine, several in vitro and in vivo investigations have been undertaken [1]. Antioxidant [2], anti-inflammatory [3], hepatoprotective, anticancer [4], nephroprotective [5], antimicrobial, antiallergic [6], immunostimulatory, antifungal [7], and gastrointestinal transition stimulatory activities have all been demonstrated in date extracts [8]. In an Alzheimer's disease transgenic mouse model, date supplementation proved to be beneficial [9].…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Phoenix dactylifera Date Palm Pollen against Doxorubicin-Induced Toxicity in the Liver, Kidney, Testis and Biochemical Parameters in Male Rats

Hassan¹,

Ahmed²,

Hameed³

2021

JPRI

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Date palm pollen (DPP) has a prophylactic role, known for its antioxidant effects. For this, the present study was designed to study the protective role of DPP against histological toxicity in hepatic, renal, and testicular tissues, as well as the level of (Total cholesterol, Triglyceride, Total proteins, Albumin, and testosterone hormone) in male white rats. The Iraqi date palm trees (Phoenix dactylifera L.) were selected from Salah Aldeen farms located at Salah Aldeen governorate. Pollen was collected from 20th March to 25th April 2019. This study used 20 male white rats that were distributed to four groups and weights close. All groups were given food and water continuously throughout the experiment, the second group (DPP) was given an orally administered suspension of date palm pollen (60 mg/kg) every day for four weeks, the third group intraperitoneal injections were given (10 mg/kg), and the fourth group (10 mg/kg) were given intraperitoneal injections one time per week and four weeks, in addition to that, orally-administered suspension of DPP (60 mg/kg) was given as well every day for four weeks. The results of the study showed a significant increase (P≤0.05) in the level of total cholesterol (TC), triglycerides (TG), and a significant decrease (P≤0.05) in the level of Total Protein, Albumin, and testosterone hormones, Current results suggest that the protective effect of (DPP) may by its antioxidant properties, and thus reduce the positive effects.

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Anti-Allergic Properties of a Matured Fruit Extract of the Date Palm Tree (Phoenix dactylifera L.) in Mite-Sensitized Mice

Cited by 21 publications

References 18 publications

Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats

Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats

The Emerging Australian Date Palm Industry: Date Fruit Nutritional and Bioactive Compounds and Valuable Processing By‐Products

Protective Role of Phoenix dactylifera Date Palm Pollen against Doxorubicin-Induced Toxicity in the Liver, Kidney, Testis and Biochemical Parameters in Male Rats

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