Anti-Alopecia Characteristics of Ethanol Extract, n-Hexane, Ethyl acetate and Water Fractions of <i>Malvaviscus arboreus</i> Cav

Mustarichie, Resmi; Wicaksono, Imam Adi; Hayati, Chusnul

doi:10.5958/0974-360x.2018.00924.1

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmacological studies are also crucial for the evaluation of toxicity or potential side effects of any extract consumed by the people for the treatments of their diseases. Several researchers have reported multiple bioactivities of S. androgynus using pharmacological studies [ 163 – 167 ]. Various bioactivities of S. androgynus are discussed in the subsequent sections and are summarised in Fig.…”

Section: Pharmacology Of Sauropus Androgynusmentioning

confidence: 99%

“…Topical application of S. androgynus mixed with milk induces hair growth in bald people of Kampung Mak Kemas community, Malaysia [ 211 ]. Mustarichie et al [ 167 ] demonstrated that 10–25% of ethanol extract-water fraction of S. androgynus is capable of inducing hair growth in male rabbits. Anti-alopecia property of S. androgynus was performed by Praceka et al [ 212 ] and identified eleven compounds in their study namely, 6-piperidin-1- Ylpyrimidine-2,4-diamine 3-oxide minoxidil, 5-alpha dihydrotestosterone, finasteride, 1,14-tetradecanediol, octadec-1-ene, 1-hexadecene, decanoic acid, phytol, azulene, pyrene and (4s,4’s)-4,4’-(propane-1,3- diyl)bis(3-amino-4-ethyl 1h-pyrazole-5(4h)-one) through computation based molecular modelling.…”

Section: Pharmacology Of Sauropus Androgynusmentioning

confidence: 99%

See 1 more Smart Citation

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

2022

View full text Add to dashboard Cite

Various plants form the basis of multiple traditional ethnic cuisines and ethnomedicinal practices across the globe. The ethnic cuisines cater to the nutritional, dietary and medicinal requirements of the tribal and rural communities even today. Using literature from various scholarly databases, this study was conducted to consolidate a comprehensive review on the use of Sauropus androgynus (L.) Merr. in various traditional ethnic cuisines and ethnomedicinal preparations across the globe. The survey shows that it is used in multiple ethnic cuisines and is variously known in different countries and among the communities. Further, it possesses multiple nutritional and ethnomedicinal properties. Considering its importance in ethnic foods and ethnomedicinal preparations, it is important to investigate the nutritional composition, phytochemical constitution and pharmacological basis of ethnomedicinal uses. Therefore, we further compiled this information and found that it is a rich source of both micro- and macronutrients and packed with several bioactive compounds. Survey of pharmacological studies on its traditional medicinal uses supports its ethnomedicinal properties. Despite its importance in traditional food and ethnomedicinal systems, it remains underexplored. Limited information on the toxicity of its various extracts shows that further studies should be conducted to understand its safety aspects. Further clinical studies to prospect possible drug candidates from it should be attempted.

show abstract

Section: Pharmacology Of Sauropus Androgynusmentioning

confidence: 99%

Section: Pharmacology Of Sauropus Androgynusmentioning

confidence: 99%

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

2022

View full text Add to dashboard Cite

show abstract

“…One study tested various fractions of the plant extract, ethanolic, n-hexane, ethyl acetate, and aqueous against the positive control 15% minoxidil, yielding comparable results. 14 Furthermore, the petroleum ether fraction, dichloromethane, ethyl acetate, and aqueous fractions from the aerial part of M. arboreus had hepatoprotective effects. 15 Rats were given the fractions orally for 6 days, followed by induction of hepatotoxicity by carbon tetrachloride.…”

Section: Introductionmentioning

confidence: 97%

In silico Prediction of Malvaviscus arboreus Metabolites and Green Synthesis of Silver Nanoparticles – Opportunities for Safer Anti-Bacterial and Anti-Cancer Precision Medicine

Mohammed¹,

Alghamdi²,

Shami³

et al. 2023

IJN

View full text Add to dashboard Cite

Biogenic silver nanoparticles (AgNPs) may be a feasible therapeutic option in the research and development towards selectively targeting specific cancers and microbial infections, lending a role in precision medicine. In-silico methods are a viable strategy to aid in drug discovery by identifying lead plant bioactive molecules for further wet lab and animal experiments. Methods: Green synthesis of M-AgNPs was performed using the aqueous extract from the Malvaviscus arboreus leaves, characterized using UV spectroscopy, FTIR, TEM, DLS, and EDS. In addition, Ampicillin conjugated M-AgNPs were also synthesized. The cytotoxic potential of the M-AgNPs was evaluated using the MTT assay on MDA-MB 231, MCF10A, and HCT116 cancer cell lines. The antimicrobial effects were determined using the agar well diffusion assay on methicillin-resistant S. aureus (MRSA) and S. mutans, E. coli, and Klebsiella pneumoniae. Additionally, LC-MS was used to identify the phytometabolites, and in silico techniques were applied to determine the pharmacodynamic and pharmacokinetic profiles of the identified metabolites. Results: Spherical M-AgNPs were successfully biosynthesized with a mean diameter of 21.8 nm and were active on all tested bacteria. Conjugation with ampicillin increased the susceptibility of the bacteria. These antibacterial effects were most predominant in Staphylococcus aureus (p < 0.0001). M-AgNPs had potent cytotoxic activity against the colon cancer cell line (IC 50 =29.5 μg/mL). In addition, four secondary metabolites were identified, Astragalin, 4-hydroxyphenyl acetic acid, Caffeic acid, and Vernolic acid. In silico studies identified Astragalin as the most active antibacterial and anti-cancer metabolite, binding strongly to the carbonic anhydrase IX enzyme with a comparatively higher number of residual interactions. Discussion: Synthesis of green AgNPs presents a new opportunity in the field of precision medicine, the concept centered on the biochemical properties and biological effects of the functional groups present in the plant metabolites used for reduction and capping. M-AgNPs may be useful in treating colon carcinoma and MRSA infections. Astragalin appears to be the optimal and safe lead for further anti-cancer and anti-microbial drug development.

show abstract

“…Treatments for seborrheic dermatitis, including keratolytic agents, aid in the removal of the hyperproliferative outer layer of the stratum corneum [ 26 ]. Antifungal agents target Malassezia, while anti-inflammatories such as corticosteroids effectively mitigate the skin’s inflammatory response [ 27 ]. Ketoconazole, an imidazole derivative from the azole group of antifungals, inhibits CYP51A1 by forming a coordinate bond between the nucleophilic nitrogen of the azole heterocycle (N3 imidazole and N4 triazole) and the heme iron in the iron state of the enzyme active site.…”

Section: Introductionmentioning

confidence: 99%

Cassia alata L.: A Study of Antifungal Activity against Malassezia furfur, Identification of Major Compounds, and Molecular Docking to Lanosterol 14-Alpha Demethylase

Saptarini,

Mustarichie,

Hasanuddin

et al. 2024

Pharmaceuticals

Self Cite

View full text Add to dashboard Cite

Empirically, in Indonesia, the leaves of Cassia alata L. (candle bush or ketepeng cina) have been used as a topical antifungal agent. Malassezia furfur is a natural microorganism found in the human body. It is among the factors contributing to conditions such as pityriasis versicolor, a common, benign, superficial fungal infection of the skin that is closely associated with seborrheic dermatitis and dandruff. This study aimed to explore C. alata leaves, starting from determining antifungal activity against M. furfur and the identification of major compounds in the ethyl acetate and n-hexane fractions, and then we carried out molecular docking of the major compounds in the n-hexane fraction to lanosterol 14-alpha demethylase. The method was the disc diffusion technique to test antifungal activity, LC-MS/MS for major compound identification, and homology modeling through Swiss Models for molecular docking. The fractions of ethyl acetate and n-hexane extract showed concentration-dependent antifungal activity against M. furfur. The LCMS/MS analysis revealed five major compounds in the ethyl acetate and n-hexane fractions. The molecular docking demonstrated the highest binding affinity with stearidonic acid at −7.2 kcal/mol. It can be concluded that the compounds in the n-hexane fraction have antifungal activity against M. furfur, as supported by both in vitro and in silico studies.

show abstract

Anti-Alopecia Characteristics of Ethanol Extract, n-Hexane, Ethyl acetate and Water Fractions of Malvaviscus arboreus Cav

Cited by 4 publications

References 0 publications

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

In silico Prediction of Malvaviscus arboreus Metabolites and Green Synthesis of Silver Nanoparticles – Opportunities for Safer Anti-Bacterial and Anti-Cancer Precision Medicine

Cassia alata L.: A Study of Antifungal Activity against Malassezia furfur, Identification of Major Compounds, and Molecular Docking to Lanosterol 14-Alpha Demethylase

Contact Info

Product

Resources

About