Anti-Alzheimer activity of isolated karanjin from Pongamia pinnata (L.) pierre and embelin from Embelia ribes Burm.f.

Saini, Prachi; Lakshmayya, L; Bisht, Vinod Singh

doi:10.4103/ayu.ayu_174_16

Cited by 19 publications

(1 citation statement)

References 33 publications

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“…Karanjin (3-methoxy-2-phenylfuro [2,3-h] chromen-4-one) ( Figure 7 ) is a furanoflavonoid isolated from Pongamia pinnata and showed neuroprotective [ 131 ] and antitumor effects [ 132 ] in experimental models. Karanjin (10 and 20 mg/kg) and omeprazole (20 mg/kg) showed gastroprotective activity in the ethanol and stress model, inhibited oxidative stress, with reduced levels of lipid peroxidation and increased activity of antioxidant enzymes (CAT, GPx, and SOD).…”

Section: Resultsmentioning

confidence: 99%

A Review of the Role of Flavonoids in Peptic Ulcer (2010–2020)

et al. 2020

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Peptic ulcers are characterized by erosions on the mucosa of the gastrointestinal tract that may reach the muscle layer. Their etiology is multifactorial and occurs when the balance between offensive and protective factors of the mucosa is disturbed. Peptic ulcers represent a global health problem, affecting millions of people worldwide and showing high rates of recurrence. Helicobacter pylori infection and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most important predisposing factors for the development of peptic ulcers. Therefore, new approaches to complementary treatments are needed to prevent the development of ulcers and their recurrence. Natural products such as medicinal plants and their isolated compounds have been widely used in experimental models of peptic ulcers. Flavonoids are among the molecules of greatest interest in biological assays due to their anti-inflammatory and antioxidant properties. The present study is a literature review of flavonoids that have been reported to show peptic ulcer activity in experimental models. Studies published from January 2010 to January 2020 were selected from reference databases. This review refers to a collection of flavonoids with antiulcer activity in vivo and in vitro models.

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Section: Resultsmentioning

confidence: 99%

A Review of the Role of Flavonoids in Peptic Ulcer (2010–2020)

et al. 2020

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Multireceptor Analysis for Evaluating the Antidiabetic Efficacy of Karanjin: A Computational Approach

Nag,

Stany,

Mishra

et al. 2024

Endocrino Diabet & Metabol

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BackgroundDiabetes mellitus, notably type 2, is a rising global health challenge, prompting the need for effective management strategies. Common medications such as metformin, insulin, repaglinide and sitagliptin can induce side effects like gastrointestinal disturbances, hypoglycemia, weight gain and specific organ risks. Plant‐derived therapies like Karanjin from Pongamia pinnata present promising alternatives due to their historical use, holistic health benefits and potentially fewer adverse effects. This study employs in silico analysis to explore Karanjin's interactions with diabetes‐associated receptors, aiming to unveil its therapeutic potential while addressing the limitations and side effects associated with conventional medications.MethodologyThe research encompassed the selection of proteins from the Protein Data Bank (PDB), followed by structural refinement processes and optimization. Ligands such as Karanjin and standard drugs were retrieved from PubChem, followed by a comprehensive analysis of their ADMET profiling and pharmacokinetic properties. Protein–ligand interactions were evaluated through molecular docking using AutoDockTools 1.5.7, followed by the analysis of structural stability using coarse‐grained simulations with CABS Flex 2.0. Molecular dynamics simulations were performed using Desmond 7.2 and the OPLS4 force field to explore how Karanjin interacts with proteins over 100 nanoseconds, focusing on the dynamics and structural stability.ResultsKaranjin, a phytochemical from Pongamia pinnata, shows superior drug candidate potential compared to common medications, offering advantages in efficacy and reduced side effects. It adheres to drug‐likeness criteria and exhibits optimal ADMET properties, including moderate solubility, high gastrointestinal absorption and blood–brain barrier penetration. Molecular docking revealed Karanjin's highest binding energy against receptor 3L2M (Pig pancreatic alpha‐amylase) at −9.1 kcal/mol, indicating strong efficacy potential. Molecular dynamics simulations confirmed stable ligand–protein complexes with minor fluctuations in RMSD and RMSF, suggesting robust interactions with receptors 3L2M.ConclusionKaranjin demonstrates potential in pharmaceutical expansion for treating metabolic disorders such as diabetes, as supported by computational analysis. Prospects for Karanjin in pharmaceutical development include structural modifications for enhanced efficacy and safety. Nanoencapsulation may improve bioavailability and targeted delivery to pancreatic cells, while combination therapies could optimize treatment outcomes in diabetes management. Clinical trials and experimental studies are crucial to validate its potential as a novel therapeutic agent.

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Scientific Basis of Ayurvedic Medicine: In Hunt for a Cure to Alzheimer’s Disease

Bhattacharjee

2019

Application of Biomedical Engineering in Neuroscience

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Anti-Alzheimer activity of isolated karanjin from Pongamia pinnata (L.) pierre and embelin from Embelia ribes Burm.f.

Cited by 19 publications

References 33 publications

A Review of the Role of Flavonoids in Peptic Ulcer (2010–2020)

A Review of the Role of Flavonoids in Peptic Ulcer (2010–2020)

Multireceptor Analysis for Evaluating the Antidiabetic Efficacy of Karanjin: A Computational Approach

Scientific Basis of Ayurvedic Medicine: In Hunt for a Cure to Alzheimer’s Disease

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