Anti-Alzheimer, anti-diabetic, skin-whitening, and antioxidant activities of the essential oil of Cinnamomum zeylanicum

Tepe, Arzuhan Şihoğlu; Özaslan, Mehmet

doi:10.1016/j.indcrop.2019.112069

Cited by 55 publications

(23 citation statements)

References 48 publications

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“…v/w) than for the Sri Wijaya by the same distillation method in another study ( Lokuge et al, 2018 ) . In the current study, the percent yields obtained for SW, SG, and CC extracts prepared using SD were comparable to the previously reported yield (2.6%) for the commercially available C. zeylanicum in Turkey ( Sihoglu Tepe & Ozaslan, 2020 ). Another finding showed a 352 mg/g yield for the freeze dried aqueous extract of C .…”

Section: Discussionsupporting

confidence: 90%

“…Cinnamaldehyde is identified as the major compound present in Cinnamon extracted using hydro distillation in several studies (Kaskoos, 2019;Mota, Campelo & Frota, 2019). The α-amylase inhibition evaluated using a combination of (E)-Cinnamaldehyde and (E)-Cinnamyl acetate has shown better potency than Cinnamaldehyde alone (Sihoglu Tepe & Ozaslan, 2020). The synergy between (E)-Cinnamaldehyde and (E)-Cinnamyl acetate seems to be important for potent enzyme inhibition.…”

Section: /18mentioning

confidence: 99%

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In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Wariyapperuma

Kannangara

Wijayasinghe

et al. 2020

PeerJ

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Background Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine. α-amylase and α-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC). Methods Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), α-amylase and α-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The α-amylase and α-glucosidase inhibition were reported in terms of IC50 value. The phytochemical profiling was accomplished by GC-MS technique. Results and Discussion Lowest IC50 values were observed in PWE and DWE of SW. The highest PC and TPC were also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from cinnamon. Benzoic acid, cinnamyl alcohol, benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts. Conclusions This is the first study to explore the use of pressured and decoctions water to extract anti-diabetic phytochemicals from cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes.

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Section: Discussionsupporting

confidence: 90%

Section: /18mentioning

confidence: 99%

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Wariyapperuma

Kannangara

Wijayasinghe

et al. 2020

PeerJ

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“…Recently, Tepe and Ozaslan [91] investigated the anti-Alzheimer's, anti-diabetic, and skin whitening effects of C. zeylanicum (Blume) EO and its major components (E)-cinnamaldehyde (81.39%) and (E)-cinnamyl acetate (4.20%). The EO and the major compounds, (E)-cinnamaldehyde and (E)-cinnamyl acetate, showed over 78.0% anticholinesterase activity.…”

Section: Cinnamomum Zeylanicum (True Cinnamon)mentioning

confidence: 99%

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

et al. 2020

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Spice plants have a great influence on world history. For centuries, different civilizations have used them to condiment the foods of kings and nobles and applied them as embalming preservatives, perfumes, cosmetics, and medicines in different regions of the world. In general, these plants have formed the basis of traditional medicine and some of their derived substances have been utilized to treat different human diseases. Essential oils (EOs) obtained from these plants have been also used as therapeutic agents and have shown supportive uses in remedial practices. The discovery and development of bioactive compounds from these natural products, based on their traditional uses, play an important role in developing the scientific evidence of their potential pharmaceutical, cosmetic, and food applications. In the present review, using recent studies, we exhibit a general overview of the main aspects related to the importance of spice plants widely used in traditional medicine: Cinnamomum zeylanicum (true cinnamon), Mentha piperita (peppermint), Ocimum basilicum (basil), Origanum vulgare (oregano), Piper nigrum (black pepper), Rosmarinus officinalis (rosemary), and Thymus vulgaris (thyme); and we discuss new findings of the bioactive compounds obtained from their EOs, their potential applications, as well as their molecular mechanisms of action, focusing on their antioxidant activity. We also exhibit the main in vitro methods applied to determine the antioxidant activities of these natural products.

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“…Cinnamaldehyde is identified as the major compound present in Cinnamon extracted using hydro distillation in several studies (Paranagama et al, 2001;Kaskoos, 2019;Mota, Campelo & Frota, 2019). The α-amylase inhibition evaluated using a combination of (E)-Cinnamaldehyde and (E)-Cinnamyl acetate has shown better potency than Cinnamaldehyde alone (Sihoglu Tepe & Ozaslan, 2020). The synergy between (E)-Cinnamaldehyde and (E)-Cinnamyl acetate seems to be important for potent enzyme inhibition Therefore, poor enzyme inhibition observed in SD and SE are consistent with the absence of (E)-Cinnamyl acetate.…”

Section: Gc-ms Technique Is a Powerful And Suitable Tool For The Detementioning

confidence: 99%

Peer Review #1 of "In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts (v0.1)"

Nasri¹

2020

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Background: Diabetes mellitus type 2 (DMT2) is a common metabolic disorder in the world. Antidiabetic actions of phytochemicals from various medicinal herbs are considered as an alternative to the drugs used in the management of DMT2 in allopathic medicine due to adverse effects of synthetic drugs. α-amylase and α-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC). Methods: Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), α-amylase and α-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The α-amylase and α-glucosidase inhibition were reported in terms of IC 50 value. The phytochemical profiling was accomplished by GC-MS technique. Results and discussion: Lowest IC 50 values were observed in PWE and DWE of SW. Highest PC and TPC was also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from Cinnamon. Benzoic acid, Cinnamyl alcohol, Benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts. Conclusions: This is the first study to explore the use of pressured and decoctions water to extract antidiabetic phytochemicals from Cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes.

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Anti-Alzheimer, anti-diabetic, skin-whitening, and antioxidant activities of the essential oil of Cinnamomum zeylanicum

Cited by 55 publications

References 48 publications

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

Peer Review #1 of "In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts (v0.1)"

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