Anti-Amyloid Aggregation Activity of Black Sesame Pigment: Toward a Novel Alzheimer’s Disease Preventive Agent

Abstract

Black sesame pigment (BSP) represents a low cost, easily accessible material of plant origin exhibiting marked antioxidant and heavy metal-binding properties with potential as a food supplement. We report herein the inhibitory properties of the potentially bioaccessible fraction of BSP following simulated gastrointestinal digestion against key enzymes involved in Alzheimer’s disease (AD). HPLC analysis indicated that BSP is transformed under the pH conditions mimicking the intestinal environment and the most abundant of the released compounds was identified as vanillic acid. More than 80% inhibition of acetylcholinesterase-induced aggregation of the β-amyloid Aβ1-40 was observed in the presence of the potentially bioaccessible fraction of BSP, which also efficiently inhibited self-induced Aβ1-42 aggregation and β-secretase (BACE-1) activity, even at high dilution. These properties open new perspectives toward the use of BSP as an ingredient of functional food or as a food supplement for the prevention of AD.

Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer’s Disease Based on Systems Pharmacology

“…P-coumaric acid (OB = 43.29, DL = 0.04) can relieve the neuroinflammatory responses induced by amyloid-beta peptide [ 61 ]. Vanillic acid exhibits marked antioxidant properties [ 62 ]. P-MCA (p-methoxycinnamic acid, OB = 31, DL = 0.05) exerts antihyperglycemic [ 63 ] and neuroprotective effects [ 64 ].…”

In silico study of natural compounds from sesame against COVID-19 by targeting Mpro, PLpro and RdRp

“…1 Structure of the isolated compounds. pinoresinol 3, 26 ferulic acid 4, 27 vanillic acid 5, 28 hydroxymatairesinol 6. 29 which is rst isolated from the species Sesamum indicum L. Spicatolignan 7, which is rst isolated from the genus Sesamum, 30 Fig.…”

Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease

“…Moreover, a novel composition of palm oil, which is rich in PCA and 4-hydroxybenzoic acid, with lesser amounts of syringic, gallic, and vanillic acids, has been proposed for the treatment of Alzheimer’s disease based on its ability to inhibit amyloid beta fibril formation [205]. Extracts rich in vanillic acid from cyanobacteria and biotransformed black sesame seed pigment have also shown inhibitory activity towards amyloid beta aggregate formation, and were reported to significantly reduce the activity of beta-secretase and prevent the toxicity of such aggregates [184,206]. In a similar fashion, both PCA and GA were found to inhibit the formation of toxic α-synuclein fibrils, destabilize pre-formed fibrils of this protein, and preserve cellular viability in a cell line treated with α-synuclein oligomers and protofibrils [192,204,207].…”