Anti- and pro-oxidative activity measured directly as the extent of 8-oxoguanine production

Puzzling Aqueous Solubility of Guanine Obscured by the Formation of Nanoparticles

“… a In our paper on guanine electrochemistry, we supposed that there might be a difference in guanine solubility in potassium and sodium phosphate buffers, but repeated measurements done within this work indicated that different electrochemical responses observed were not due to the differences in solubilities, which were shown to be not statistically significant. …”

“…In many papers, it was claimed that solutions of concentrations up to 100 μM were used at pH 7, a value exceeding the above-mentioned reported values of solubility. In some other, also our own, the work solutions were prepared by diluting the saturated stock solution, the concentration of which was assumed to be 40 μM. However, some other researchers determined themselves the concentration of their saturated solutions, interestingly, each time obtaining slightly different values, but generally close to 25 μM …”

“…In many papers, it was claimed that solutions of concentrations up to 100 μM were used at pH 7, a value exceeding the above-mentioned reported values of solubility. In some other, also our own, 4 the work solutions were prepared by diluting the saturated stock solution, the concentration of which was assumed to be 40 μM.…”