Anti-androgen Treatments

Bachelot, Anne; Chabbert-Buffet, Nathalie; Salenave, Sylvie; Kerlan, V.; Galand-Portier, Marie-Béatrice

doi:10.1016/j.ando.2009.12.001

Cited by 26 publications

(4 citation statements)

References 42 publications

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“…This result was underreported in the literature and consistent with the report of Arora et al [15] that the lower serum estrogen level was observed in patients with acne vulgaris. In addition, a few clinical trials indicated that topical application of antiandrogens had demonstrated efficacy and effectiveness in acne treatment [16,17,18]. The trials mentioned above indirectly supported our findings.…”

Section: Discussionsupporting

confidence: 80%

Higher 17α-Hydroxyprogesterone Levels Aggravated the Severity of Male Adolescent Acne in Northeast China

Wei

Qu²,

Zhu³

et al. 2014

Dermatology

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Background: The relationship between serum hormone levels and adolescent acne is not fully clarified. Objective: To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17α-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China. Methods: A transversal study included 242 acne cases and 188 controls. All data were analyzed using SPSS version 17.0. Results: Androstenedione and testosterone levels were significantly higher (p < 0.0001) in the cases than in the control group. In males, the difference in 17-OHP levels was statistically significant (p < 0.0001), as well as between mild and severe acne cases (p = 0.002). The estradiol level was significantly different (p < 0.0001) between cases and controls in females. Conclusion: Higher androstenedione and testosterone levels are significant risk factors in the occurrence of adolescent acne. A higher 17-OHP level aggravates the severity of male adolescent acne, while a higher estradiol level protects females against the onset of adolescent acne.

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Section: Discussionsupporting

confidence: 80%

Higher 17α-Hydroxyprogesterone Levels Aggravated the Severity of Male Adolescent Acne in Northeast China

Wei

Qu²,

Zhu³

et al. 2014

Dermatology

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“…The diagnosis of SAHA syndrome requires a complete history, physical examination with emphasis on evidence of androgen excess and appropriate laboratory investigations (including hormones such as DHEA sulphate, testosterone, prolactin and 17‐OH‐progesterone) to exclude hyperandrogenaemia 28,34 . Treatments for the dermatological conditions of hyperandrogenism include lifestyle modification, oral contraceptives, anti‐androgens and insulin‐sensitizing medications 37,41,42 …”

Section: Saha Syndromementioning

confidence: 99%

“…28,34 Treatments for the dermatological conditions of hyperandrogenism include lifestyle modification, oral contraceptives, anti-androgens and insulin-sensitizing medications. 37,41,42…”

Section: Saha Syndromementioning

confidence: 99%

Acne‐associated syndromes: models for better understanding of acne pathogenesis

Chen

Obermayer-Pietsch

Hong

et al. 2010

Acad Dermatol Venereol

117

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Acne, one of the most common skin disorders, is also a cardinal component of many systemic diseases or syndromes. Their association illustrates the nature of these diseases and is indicative of the pathogenesis of acne. Congenital adrenal hyperplasia (CAH) and seborrhoea-acne-hirsutism-androgenetic alopecia (SAHA) syndrome highlight the role of androgen steroids, while polycystic ovary (PCO) and hyperandrogenism-insulin resistance-acanthosis nigricans (HAIR-AN) syndromes indicate insulin resistance in acne. Apert syndrome with increased fibroblast growth factor receptor 2 (FGFR2) signalling results in follicular hyperkeratinization and sebaceous gland hypertrophy in acne. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) and pyogenic arthritis-pyoderma gangrenosum-acne (PAPA) syndromes highlight the attributes of inflammation to acne formation. Advances in the understanding of the manifestation and molecular mechanisms of these syndromes will help to clarify acne pathogenesis and develop novel therapeutic modalities.

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“…The pattern of the syndrome can markedly vary regarding the expressiveness and the severity of the clinical signs from only cosmetical discomfort to serious illness [ 95 , 101 , 103 ] ( Table 2 ). Lifestyle modification, oral contraceptives, anti-androgens, and insulin-sensitizing medications are treatments for the dermatological conditions of hyperandrogenism [ 104 , 105 ].…”

Section: Acne-associated Endocrine/immunological Syndromesmentioning

confidence: 99%

Acne Syndromes and Mosaicism

Baroud

Zouboulis

2021

Biomedicines

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Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chronic illness characterized by inflammatory changes around and in the pilosebaceous units, commonly due to hormone- and inflammatory signaling-mediated factors. Several systemic disorders, such as congenital adrenal hyperplasia, polycystic ovarian syndrome, and seborrhoea-acne-hirsutism-androgenetic alopecia syndrome have classically been associated with acne. Autoinflammatory syndromes, including PAPA, PASH, PAPASH, PsAPASH, PsaPSASH, PASS, and SAPHO syndromes include acneiform lesions as a key manifestation. Mosaic germline mutations in the FGFR2 gene have been associated with Apert syndrome and nevus comedonicus, two illnesses that are accompanied by acneiform lesions. In this review, we summarize the concept of cutaneous mosaicism and elaborate on acne syndromes, as well as acneiform mosaicism.

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Anti-androgen Treatments

Cited by 26 publications

References 42 publications

Higher 17α-Hydroxyprogesterone Levels Aggravated the Severity of Male Adolescent Acne in Northeast China

Higher 17α-Hydroxyprogesterone Levels Aggravated the Severity of Male Adolescent Acne in Northeast China

Acne‐associated syndromes: models for better understanding of acne pathogenesis

Acne Syndromes and Mosaicism

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