Anti-Angiogenesis Therapy and its Combination with Chemotherapy: Impact on Primary Tumor and its Metastasis

Mousa, Shaker A.; Sudha, Thangirala; Davis, Paul J.

doi:10.1016/b978-0-12-802576-5.00010-3

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…Although these clinically approved anti-angiogenic drugs have proved a certain effectiveness towards reducing tumor angiogenesis by normalizing the hyperpermeable tumor vessels, metastasis and mortality continuously occur after treatment. As a consequence, inhibition of VEGFR or tyrosine kinase receptors are insufficient for stopping the neovascularization process [118,119]. Additionally, the administration of anti-angiogenic agents results in the development of an innate or adaptive resistance towards treatment partly due to changes in the immune microenvironment of the tumor [120].…”

Section: Conventional Anti-angiogenic Drugs and Their Limitationsmentioning

confidence: 99%

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

373

251

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Angiogenesis is the process through which novel blood vessels are formed from pre-existing ones and it is involved in both physiological and pathological processes of the body. Furthermore, tumor angiogenesis is a crucial factor associated with tumor growth, progression, and metastasis. In this manner, there has been a great interest in the development of anti-angiogenesis strategies that could inhibit tumor vascularization. Conventional approaches comprise the administration of anti-angiogenic drugs that target and block the activity of proangiogenic factors. However, as their efficacy is still a matter of debate, novel strategies have been focusing on combining anti-angiogenic agents with chemotherapy or immunotherapy. Moreover, nanotechnology has also been investigated for the potential of nanomaterials to target and release anti-angiogenic drugs at specific sites. The aim of this paper is to review the mechanisms involved in angiogenesis and tumor vascularization and provide an overview of the recent trends in anti-angiogenic strategies for cancer therapy.

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Section: Conventional Anti-angiogenic Drugs and Their Limitationsmentioning

confidence: 99%

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

373

251

View full text Add to dashboard Cite

show abstract

“…Hypoxia increases the production of proangiogenic factors by tumor cells, macrophages, and other immune cells from the tumor microenvironment . Targeting tumor vessels with natural compounds such as trabectedin, plitidepsin, and combretastatins, which induce tumor starvation, has gained space and interest in cancer drug development for advanced cancers . These compounds showed significant improvement in clinical outcomes and might become an alternative therapeutic for these challenging cancers according to recent human clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive biomarkers

2018

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The high mortality associated with oncological diseases is mostly due to tumors in advanced stages, and their management is a major challenge in modern oncology. Angiogenesis is a defined hallmark of cancer and predisposes to metastatic invasion and dissemination and is therefore an important druggable target for cancer drug discovery. Recently, because of drug resistance and poor prognosis, new anticancer drugs from natural sources targeting tumor vessels have attracted more attention and have been used in several randomized and controlled clinical trials as therapeutic options. Here, we outline and discuss potential natural compounds as salvage treatment for advanced cancers from recent and ongoing clinical trials and real‐world studies. We also discuss predictive biomarkers for patients' selection to optimize the use of these potential anticancer drugs.

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Angiogenesis in glioma

Wang

2018

Glioma

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Anti-Angiogenesis Therapy and its Combination with Chemotherapy: Impact on Primary Tumor and its Metastasis

Cited by 3 publications

References 45 publications

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive biomarkers

Angiogenesis in glioma

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