Anti-angiogenic and anti-inflammatory effects of CD200–CD200R1 axis in oxygen-induced retinopathy mice model

Hu, Yuwen; Wei, Ting; Gao, Shan; Cheng, Qiaochu

doi:10.1007/s00011-019-01276-2

Cited by 6 publications

(9 citation statements)

References 44 publications

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“…In addition to the neuro-and tissue-protection abilities, EPO and PDGF were proven to associate with the brosis and in ammation process in different organs [15,16,[31][32][33]. Thus, the uctuation of these proteins could correlate with the outcome of trabeculectomy.…”

Section: Discussionmentioning

confidence: 99%

“…There are emerging evidences for the neuroprotection effect of EPO both in vivo and in vitro [21,38,39]. The positive roles that EPO may play in APAC under higher dose, such as anti-apoptotic [12,13], anti-oxidant [14], and antiin ammatory [15,16] make it an ideal treatment in APAC. However, its role in angiogenesis, causing neovascularization is a dreaded occurrence in the eye [40].…”

Section: Discussionmentioning

confidence: 99%

“…In those conditions, retinal ganglion cells called for much higher level of EPO to ght against the oxygen-de cient environment. Some studies have shown the antibrosis [33] and anti-in ammation [16] abilities of EPO. However, various factors in the aqueous humor were found rising during acute angle closure, such as matricellular proteins and in ammation factors.…”

Section: Discussionmentioning

confidence: 99%

“…However, there has been no research describing the changes of EPO and PDGF levels in APAC eyes. Recent studies have shown that both EPO and PDGF have neuroprotective functions such as anti-apoptotic [12,13], anti-oxidant [14] and anti-in ammatory properties [15,16]. Thus, the uctuations of their levels in aqueous humor may correlate with prognosis of trabeculectomy in APAC eyes.…”

Section: Introductionmentioning

confidence: 99%

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Potential Effects of Angiogenesis-related Factors on the Severity of APAC and Surgical Outcomes of Trabeculectomy

Wang

Zhou

et al. 2020

Preprint

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Background. Acute primary angle closure (APAC) caused by an abrupt closure of trabecular meshwork can develop into angle closure glaucoma due to uncontrolled IOP. Under reduced oxygen tension, hypoxia inducible transcription factors will be accumulated. EPO (erythropoietin) and PDGF (platelet derived growth factor) families are thought to be associated with angiogenesis under hypoxic condition.Methods. Concentrations of EPO, PDGF-AA, -BB, -CC and -DD collected in aqueous humor samples were measured. Before operations, correlations between target proteins and IOP were detected between APAC (acute primary angle closure) and cataract patients. Based on the post-operative follow-up, the effects of EPO and PDGF family members on the successful rate of trabeculectomy were tested. Results. The levels of EPO, PDGF-CC and -DD were significantly elevated in the APAC group compared to the cataract group. During the post-operative follow-up, EPO, PDGF-CC and -DD showed significant differences between the success and failure groups. In multivariable linear regression analyses, failed filtration surgery was more likely in APAC eyes with higher EPO level. The Kaplan-Meier survival plot suggested that the success rate in eyes with low EPO level was significantly higher than that in eyes with high EPO level.Conclusion. The levels of EPO, PDGF-CC and -DD were significantly elevated in failure group. EPO level correlated with preoperative IOP and numbers of eyedrops, and higher EPO level in aqueous humor is a risk factor for trabeculectomy failure. It can be a biomarker to estimate the severity of APAC and the success rate of surgery. The investigation of mechanism of EPO in APAC a may have potential clinical applications for the surgical treatment of APAC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential Effects of Angiogenesis-related Factors on the Severity of APAC and Surgical Outcomes of Trabeculectomy

Wang

Zhou

et al. 2020

Preprint

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“…However, there has been no research describing the changes of EPO and PDGF levels in APAC eyes. Recent studies have shown that both EPO and PDGF have neuroprotective functions such as anti-apoptotic [ 12 , 13 ], anti-oxidant [ 14 ] and anti-inflammatory properties [ 15 , 16 ]. Thus, the fluctuations of their levels in aqueous humor may correlate with prognosis of trabeculectomy in APAC eyes.…”

Section: Introductionmentioning

confidence: 99%

Potential effects of angiogenesis-related factors on the severity of APAC and surgical outcomes of trabeculectomy

Wang

Zhou

et al. 2021

BMC Ophthalmol

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Background EPO (erythropoietin) and PDGF (platelet derived growth factor) families are thought to be associated with angiogenesis under hypoxic condition. The sharp rise of intraocular pressure in acute primary angle closure (APAC) results in an inefficient supply of oxygen and nutrients. We aimed to measure the expression of EPO and PDGF family members in APAC eyes and demonstrate their associations with APAC’s surgical success rate. Methods Concentrations of EPO, PDGF-AA, -BB, -CC and -DD collected in aqueous humor samples of 55 patients recruited were measured. Before operations, correlations between target proteins and IOP (intraocular pressure) were detected between APAC (acute primary angle closure) and cataract patients. Based on the post-operative follow-up, the effects of EPO and PDGF family members on the successful rate of trabeculectomy were tested. Results The levels of EPO, PDGF-CC and -DD were significantly elevated in the APAC group compared to the cataract group. During the post-operative follow-up, EPO, PDGF-CC and -DD showed significant differences between the success and failure groups. In multivariable linear regression analyses, failed filtration surgery was more likely in APAC eyes with higher EPO level. The Kaplan-Meier survival plot suggested that the success rate in eyes with low EPO level was significantly higher than that in eyes with high EPO level. Conclusion The levels of EPO, PDGF-CC and -DD were significantly elevated in failure group. EPO level correlated with preoperative IOP and numbers of eyedrops, and higher EPO level in aqueous humor is a risk factor for trabeculectomy failure. It can be a biomarker to estimate the severity of APAC and the success rate of surgery. The investigation of mechanism of EPO in APAC a may have potential clinical applications for the surgical treatment of APAC.

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Microglia in retinal angiogenesis and diabetic retinopathy

Hu,

Schmidt,

Heinig

2024

Angiogenesis

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Diabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression and is characterized by the growth of new blood vessels in the retina at an advanced, proliferative stage. Microglia are a resident immune population in the central nervous system, known to play a crucial role in regulating retinal angiogenesis in both physiological and pathological conditions, including diabetic retinopathy. Physiologically, they are located close to blood vessels and are essential for forming new blood vessels (neovascularization). In diabetic retinopathy, microglia become widely activated, showing a distinct polarization phenotype that leads to their accumulation around neovascular tufts. These activated microglia induce pathogenic angiogenesis through the secretion of various angiogenic factors and by regulating the status of endothelial cells. Interestingly, some subtypes of microglia simultaneously promote the regression of neovascularization tufts and normal angiogenesis in neovascularization lesions. Modulating the state of microglial activation to ameliorate neovascularization thus appears as a promising potential therapeutic approach for managing diabetic retinopathy. Graphical abstract

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Anti-angiogenic and anti-inflammatory effects of CD200–CD200R1 axis in oxygen-induced retinopathy mice model

Cited by 6 publications

References 44 publications

Potential Effects of Angiogenesis-related Factors on the Severity of APAC and Surgical Outcomes of Trabeculectomy

Potential Effects of Angiogenesis-related Factors on the Severity of APAC and Surgical Outcomes of Trabeculectomy

Potential effects of angiogenesis-related factors on the severity of APAC and surgical outcomes of trabeculectomy

Microglia in retinal angiogenesis and diabetic retinopathy

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