Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus

Song, Yun Seon; Kim, Sun-Hyoung; Sa, Jae-Hoon; Jin, Changbae; Lim, Chang‐Jin; Park, Eun-Hee

doi:10.1016/s0378-8741(03)00178-8

Cited by 130 publications

(76 citation statements)

References 15 publications

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“…2D and 2E). These results are consistent with the effects of ethanol extracts of PL on radical 1,1-diphenyl-2-picrylhyrazyl (DPPH), suggesting that both water extracts and ethanol extracts may inhibit the DNA damage by directly removing the hydroxyl radical (21). On the other hand, RGE displayed protective effects against DNA strand breaks, but protected weakly at high concentrations (20 μg/ml) in DNA fragmentation assays (Fig.…”

Section: Discussionsupporting

confidence: 86%

Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage

Park¹,

Lim²,

Lee³

et al. 2009

BMB Reports

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Anti-oxidative effect of Phellinus linteus (P. linteus) and red ginseng extracts on DNA damage induced by reactive oxygen species (ROS) were investigated in this study. P. linteus (PLE) and red ginseng extracts (RGE) inhibited the breaking of E. coli ColE1 plasmid DNA strands as well as nuclear DNA of rat hepatocytes damaged by oxidative stress. In addition, a reaction mixture of PLE and RGE showed synergistic inhibitory effect against DNA damage. These results suggest that PLE and RGE have a cellular defensive effect against DNA damage induced by ROS. [BMB reports 2009; 42(8): 500-505]

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Section: Discussionsupporting

confidence: 86%

Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage

Park¹,

Lim²,

Lee³

et al. 2009

BMB Reports

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“…more than 40 years ago, an original study in Japan demonstrated that pl has the strongest antitumor effects compared to other mushrooms Medicinal mushroom Phellinus linteus as an alternative cancer therapy (Review) (13). as previously reported, pl also demonstrates immunomodulatory, anti-inflammatory, anti-allergic, anti-angiogenic and anti-oxidant effects (14)(15)(16)(17)(18). these biological effects were found to be associated with isolated polysaccharides, proteoglycans and other organic compounds such as hispolon, caffeic acid, davallialactone, interfungins a and inoscavin a (17,(19)(20)(21)(22).…”

Section: Phellinus Linteussupporting

confidence: 62%

Medicinal mushroom Phellinus linteus as an alternative cancer therapy

Slíva

2010

Experimental and Therapeutic Medicine

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Abstract. alternative cancer treatment with nutritional/dietary supplements containing a wide variety of herbal products is on the rise in Western countries. recent epidemiological studies have suggested that mushrooms may prevent against different types of cancers. Phellinus linteus is a well-known Oriental medicinal fungus with a variety of biological activities, including immunomodulatory or direct antitumor activities. the activity of P. linteus and its extracts is associated with the presence of polysaccharides, their peptide/protein complexes and other low molecular weight complexes. polysaccharide fractions isolated from P. linteus were found to be related to the increased activity of immune cells such as the production of cytokines by macrophages and B-cells or the increased cytotoxic activity of natural killer cells. moreover, P. linteus was found to modulate the expression or activity of various genes involved in cell proliferation, apoptosis, angiogenesis, invasive behavior and chemoprevention. Finally, P. linteus extracts demonstrated tumor regression in three independent case reports, suggesting that an extract from P. linteus or a dietary supplement based on the extract from P. linteus may have potential use for the alternative treatment of cancer. Contents1. introduction 2. Phellinus linteus 3. the anticancer activity of isolated compounds 4. the anticancer activity of P. linteus extracts 5. human studies 6. conclusions Introductionthe popularity of complementary and alternative medicine (cam) is steadily increasing among cancer patients, and cam represents one of the fastest growing treatment modalities in the uS (1). the most commonly used cam includes acupuncture, mind-body approaches and dietary supplements. Specifically, among cancer patients, the use of CAM ranges between 30 and 75% worldwide and includes dietary approaches, herbal and other biologically based treatments (2). For example, herbal therapies are used by more than 12% of the uS population each year, resulting in annual out-ofpocket expenses above $5 billion (3). in spite of the popularity of alternative cancer treatments with nutritional/dietary supplements among patients, sometimes based on the anecdotic evidence, cam therapies are in many cases labeled as 'pseudoscience' (4). Therefore, rigorous scientific testing and safety evaluation of dietary supplements must be performed, after which clinicians can recommend the use of a particular dietary supplement (5).Some of the popular, widely used dietary supplements are based on dried mushrooms or mushroom extracts. notably, three recent epidemiological studies from asia demonstrated an inverse correlation between mushroom intake and gastric, gastrointestinal and breast cancer, respectively (6-8). the anticancer activities of mushrooms were usually associated with the stimulation of the immune system by polysaccharides, predominantly β-glucans (9). On the other hand, mushrooms contain minerals, vitamins (e.g., thiamin, riboflavin, ascorbic acid and vitamin d), amino acids and other...

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“…Recently, Song et al (2003) demonstrated anti-angiogenic activity of PL in chorioallantoic membrane (CAM) chick embryo assay. However, the mechanism of the inhibition of angiogenesis by PL, related to cancer, was not previously addressed.…”

Section: Discussionmentioning

confidence: 99%

Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling

et al. 2008

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The antitumour activity of a medicinal mushroom Phellinus linteus (PL), through the stimulation of immune system or the induction of apoptosis, has been recently described. However, the molecular mechanisms responsible for the inhibition of invasive behaviour of cancer cells remain to be addressed. In the present study, we demonstrate that PL inhibits proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of highly invasive human breast cancer cells. The growth inhibition of MDA-MB-231 cells is mediated by the cell cycle arrest at S phase through the upregulation of p27Kip1 expression. Phellinus linteus also suppressed invasive behaviour of MDA-MB-231 cells by the inhibition of cell adhesion, cell migration and cell invasion through the suppression of secretion of urokinase-plasminogen activator from breast cancer cells. In addition, PL markedly inhibited the early event in angiogenesis, capillary morphogenesis of the human aortic endothelial cells, through the downregulation of secretion of vascular endothelial growth factor from MDA-MB-231 cells. These effects are mediated by the inhibition of serinethreonine kinase AKT signalling, because PL suppressed phosphorylation of AKT at Thr 308 and Ser 473 in breast cancer cells. Taken together, our study suggests potential therapeutic effect of PL against invasive breast cancer.

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Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus

Cited by 130 publications

References 15 publications

Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage

Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage

Medicinal mushroom Phellinus linteus as an alternative cancer therapy

Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling

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