Anti-Angiogenic Effect of Beta-Glucan Extracted From Pleurotus Spp.

“…Purity of 90% gave an indication for the successful β-glucan extraction method. HPLC was used for detecting the purity of polysaccharides including β-glucan extracted from mushrooms and yeasts (16) . FT-IR analysis of P. eryngii β-glucan with absorption range of 4000-400 cm -1 to was compared with the resulted functional groups of the standard.…”

Section: Resultsmentioning

confidence: 99%

Antitumor Activity of ?-glucan Extracted from Pleurotus Eryngii

Al-Saffar¹,

Hadi²,

Khalaf³

2020

IJFMT

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Pleurotus eryngii, a type of edible mushroom that exhibit various pharmacological properties, including antioxidant and anticancer effects. In the present study, extracted β-glucan from the P. eryngii was tested as an antioxidant and anti-tumor factor. β-glucan was extracted and analyzed by HPLC and FT-IR. Analytical results showed more than 90% similarity in chemical structure and purity. Potential antioxidant activity of β-glucan was examined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and compared with ascorbic acid. β-glucan confirmed a potential scavenging activity. The anticancer activity of the β-glucan was assessed using different concentrations (6.25 to 400 µg mL -1 ) on MCF-7 and HepG2 cell lines. P. eryngii β-glucan exerted a dose-dependent reduction in MCF-7 and HepG2 cell viability with an IC 50 of 280.00 and 539.5 µg mL -1 , respectively. At the same time, no significant effect was recorded on normal cell line WRL 68. The obtained results are expected that could be used to develop P. eryngii β-glucan as an antitumor drug.

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“…Purity of 90% gave an indication for the successful β-glucan extraction method. HPLC was used for detecting the purity of polysaccharides including β-glucan extracted from mushrooms and yeasts (16) . FT-IR analysis of P. eryngiiβ-glucan with absorption range of 4000-400 cm -1 to was compared with the resulted functional groups of the standard.…”

Section: Resultsmentioning

confidence: 99%

Antitumor Activity of ?-glucan Extracted from Pleurotus Eryngii

2020

IJFMT

View full text Add to dashboard Cite

Pleurotus eryngii, a type of edible mushroom that exhibit various pharmacological properties, including antioxidant and anticancer effects. In the present study, extracted β-glucan from the P. eryngii was tested as an antioxidant and anti-tumor factor. β-glucan was extracted and analyzed by HPLC and FT-IR. Analytical results showed more than 90% similarity in chemical structure and purity. Potential antioxidant activity of β-glucan was examined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and compared with ascorbic acid.βglucan confirmed a potential scavenging activity. The anticancer activity of theβ-glucan was assessed using different concentrations (6.25 to 400 µgmL -1 ) on MCF-7 and HepG2 cell lines. P. eryngiiβ-glucan exerted a dose-dependent reduction in MCF-7 and HepG2 cell viability with an IC 50 of 280.00 and 539.5 µg mL -1 , respectively. At the same time, no significant effect was recorded on normal cell line WRL 68. The obtained results are expected that could be used to develop P. eryngiiβ-glucanas an antitumor drug.

show abstract

Anti-Angiogenic Effect of Beta-Glucan Extracted From Pleurotus Spp.

Abstract: This study was conducted to investigate the effect of β-glucan extracted from the medicinal mushroom pleurotus eryngii as an antiangiogenic and anti-tumor factor. The β-glucan was extracted from the mushroom Pleurotus eryngii using hot water extraction method. The

Cited by 4 publications

References 20 publications

Evaluation of the biological activities of β-glucan isolated from Lentinula edodes

Evaluation of the biological activities of β-glucan isolated from Lentinula edodes

Antitumor Activity of ?-glucan Extracted from Pleurotus Eryngii

Antitumor Activity of ?-glucan Extracted from Pleurotus Eryngii

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