Anti-angiogenic effect of nano-formulated water soluble kaempferol and combretastatin in an in vivo chick chorioallantoic membrane model and HUVEC cells

Subbaraj, Gowtham Kumar; Masoodi, Tariq; Yasam, Santhosh Kumar; Chandrashekar, Kirubhanand; Kulanthaivel, Langeswaran; Shaik, Noor Ahmad; Hashem, Sheema; Akil, Ammira Al‐Shabeeb; Bhat, Ajaz A.

doi:10.1016/j.biopha.2023.114820

Cited by 6 publications

(6 citation statements)

References 33 publications

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“…Our polymeric micelle formulation, showing a sustained, prolonged release profile, was submitted to an in ovo investigation, and the lack of irritability and good bioavailability was proven using the HET-CAM assay, an optimal alternative in vivo test for toxicity studies [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Polymeric-Micelles-Based Hydrogel Containing Origanum vulgare L. Essential Oil: In Vitro Release and Permeation, Angiogenesis, and Safety Profile In Ovo

et al. 2023

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Origanum vulgare var. vulgare essential oil (OEO) is known as a natural product with multiple beneficial effects with application in dermatology. Oregano essential oil represents a potential natural therapeutic alternative for fibroepithelial polyps (FPs), commonly known as skin tags. Innovative formulations have been developed to improve the bioavailability and stability of essential oils. In this study, we aimed to evaluate the morphology of a polymeric-micelles-based hydrogel (OEO-PbH), the release and permeation profile of oregano essential oil, as well as to assess in vivo the potential effects on the degree of biocompatibility and the impact on angiogenesis in ovo, using a chick chorioallantoic membrane (CAM). Scanning electron microscopy (SEM) analysis indicated a regular aspect after the encapsulation process, while in vitro release studies showed a sustained release of the essential oil. None of the tested samples induced any irritation on the CAM and the limitation of the angiogenic process was noted. OEO-PbH, with a sustained release of OEO, potentially enhances the anti-angiogenic effect while being well tolerated and non-irritative by the vascularized CAM, especially on the blood vessels (BVs) in the presence of leptin treatment. This is the first evidence of in vivo antiangiogenic effects of a polymeric-micelle-loaded oregano essential oil, with further mechanistic insights for OEO-PbH formulation, involving leptin as a possible target. The findings suggest that the OEO-containing polymeric micelle hydrogel represents a potential future approach in the pathology of cutaneous FP and other angiogenesis-related conditions.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Polymeric-Micelles-Based Hydrogel Containing Origanum vulgare L. Essential Oil: In Vitro Release and Permeation, Angiogenesis, and Safety Profile In Ovo

et al. 2023

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“…Kaempferol also showed significant inhibition of NSCLC (non-small cell lung cancer) cell proliferation (p < 0.05) and inhibited the mesenchymal-epithelial transition in progressive lung cancer by promoting NSCLC cell autophagy, leading to NSCLC cell death in a rat model [69]. Yu et al [70] stated that kaempferol reduced inflammatory bowel disease (IBD) by inhibiting IL-1β, IL-6, TNF-α, CRP, and NO secretion as well as retarding regenerated blood vessels of high intestinal microvascular density [71]. Luteolin (abundance: 91.64 × 10 5 ) is a flavone type that is generally present in plants, with multiple functions such as antioxidant, anti-inflammatory, and antiallergic properties, in particular, against liver disorders, including metabolic-associated fatty liver disease, hepatic fibrosis, and hepatoma [72,73].…”

Section: Characterization Of Polyphenols In Spicy Basil Leaf Curry An...mentioning

confidence: 99%

Phytochemical Profiling and Antioxidant Activities of the Most Favored Ready-to-Use Thai Curries, Pad-Ka-Proa (Spicy Basil Leaves) and Massaman

Siripongvutikorn,

Pumethakul,

Yupanqui

et al. 2024

Foods

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Food is one of the factors with the highest impact on human health. Today, attention is paid not only to food properties such as energy provision and palatability but also to functional aspects including phytochemical, antioxidant properties, etc. Massaman and spicy basil leaf curries are famous Thai food dishes with a good harmony of flavor and taste, derived from multiple herbs and spices, including galangal rhizomes, chili pods, garlic bulbs, peppers, shallots, and coriander seeds, that provide an array of health benefits. The characterization of phytochemicals detected by LC-ESI-QTOF-MS/MS identified 99 components (Masaman) and 62 components (spicy basil leaf curry) such as quininic acid, hydroxycinnamic acid, luteolin, kaempferol, catechin, eugenol, betulinic acid, and gingerol. The cynaroside and luteolin-7-O-glucoside found in spicy basil leaf curry play a key role in antioxidant activities and were found at a significantly higher concentration than in Massaman curry. Phenolic and flavonoid compounds generally exhibit a bitter and astringent taste, but all the panelists scored both curries higher than 7 out of 9, confirming their acceptable flavor. Results suggest that the Massaman and spicy basil leaves contain various phytochemicals at different levels and may be further used as functional ingredients and nutraceutical products.

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“…This compound has the ability to suppress angiogenesis by preventing the activation of endothelial cells and suppressing factors of angiogenesis. [203] Kaempferol loaded in nanostructured lipid carriers Anti-cancer…”

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confidence: 99%

“…The study found that nano-formulated water-soluble combretastatin and kaempferol can suppress angiogenesis by inhibiting endothelial cell activation and angiogenesis-suppressive factors. It was also discovered that the combination of combretastatin and water-soluble kaempferol, which had been nanoformulated, performed significantly better than either treatment alone [203]. Kaempferol (KAE) loaded in nanostructured lipid carriers (NLCs) was made to evaluate its role against breast cancer cells.…”

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confidence: 99%

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Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities

Alrumaihi,

Almatroodi,

Alharbi

et al. 2024

Molecules

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Natural products and their bioactive compounds have been used for centuries to prevent and treat numerous diseases. Kaempferol, a flavonoid found in vegetables, fruits, and spices, is recognized for its various beneficial properties, including its antioxidant and anti-inflammatory potential. This molecule has been identified as a potential means of managing different pathogenesis due to its capability to manage various biological activities. Moreover, this compound has a wide range of health-promoting benefits, such as cardioprotective, neuroprotective, hepatoprotective, and anti-diabetic, and has a role in maintaining eye, skin, and respiratory system health. Furthermore, it can also inhibit tumor growth and modulate various cell-signaling pathways. In vivo and in vitro studies have demonstrated that this compound has been shown to increase efficacy when combined with other natural products or drugs. In addition, kaempferol-based nano-formulations are more effective than kaempferol treatment alone. This review aims to provide detailed information about the sources of this compound, its bioavailability, and its role in various pathogenesis. Although there is promising evidence for its ability to manage diseases, it is crucial to conduct further investigations to know its toxicity, safety aspects, and mechanism of action in health management.

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Anti-angiogenic effect of nano-formulated water soluble kaempferol and combretastatin in an in vivo chick chorioallantoic membrane model and HUVEC cells

Cited by 6 publications

References 33 publications

Cutaneous Polymeric-Micelles-Based Hydrogel Containing Origanum vulgare L. Essential Oil: In Vitro Release and Permeation, Angiogenesis, and Safety Profile In Ovo

Cutaneous Polymeric-Micelles-Based Hydrogel Containing Origanum vulgare L. Essential Oil: In Vitro Release and Permeation, Angiogenesis, and Safety Profile In Ovo

Phytochemical Profiling and Antioxidant Activities of the Most Favored Ready-to-Use Thai Curries, Pad-Ka-Proa (Spicy Basil Leaves) and Massaman

Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities

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