Anti-angiogenic therapies in brain metastases

Berghoff, Anna Sophie

doi:10.1007/s12254-018-0384-2

Cited by 28 publications

(21 citation statements)

References 28 publications

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“…Angiogenesis is defined as the physiological process that can be formed by vascular endothelial or tumor cells. An anti-angiogenic approach has been widely accepted as a most encouraging strategy to control cancer growth and metastasis (18,19). VEGF is a critical driver of sprouting angiogenesis that functions by regulating vascular formation, remodeling and permeability.…”

Section: Discussionmentioning

confidence: 99%

RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling

Zhuang

Zang

et al. 2020

Oncol Lett

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Breast cancer is the second leading primary cause for cancer-related mortality among women and metastasis to the brain is a disastrous event for patients with increasing incidence. A previous study confirmed the critical function of RRM2 in breast cancer cell growth. Unfortunately, the role and fundamental molecular mechanism of RRM2 in breast cancer metastasis remains elusive. In the current study, higher RRM2 expression was validated in breast cancer tissues, especially in the brain metastasis group. Simultaneously, the expression of RRM2 was increased in breast cancer cells relative to the normal breast epithelial cell line MCF-10A, concomitant with higher levels of RRM2 in the highly metastatic MDA-MB-231 cell line relative to the weakly metastatic MCF-7 cell line. Knockdown of RRM2 by small interfering-RRM2 transfection notably suppressed the malignant metastatic behavior of breast cancer cells, including invasion and migration. Simultaneously, RRM2 downregulation also restrained the transcription and release of vascular endothelial growth factor (VEGF) in breast cancer cells. Moreover, inhibition of RRM2 dampened the activation of phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) signaling by decreasing phosphorylated-AKT and downstream matrix metalloproteinases-2 expression.Intriguingly, reactivation of the PI3K/AKT pathway with its agonist insulin-like growth factor-1 reversed the adverse effects of RRM2 suppression on cancer cell invasion, migration and VEGF expression. Together, these findings suggest that RRM2 may act as a pro-metastatic factor to facilitate breast cancer metastasis by evoking cell invasion, migration and VEGF expression through the PI3K/AKT signaling pathway. This study may provide an attractive target for metastatic intervention in breast cancer.Key words: breast cancer, brain metastasis, RRM2, cell invasion and migration, vascular endothelial growth factor, phosphatidyl inositol 3 kinase/protein kinase B

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Section: Discussionmentioning

confidence: 99%

RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling

Zhuang

Zang

et al. 2020

Oncol Lett

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“…In brain metastases of various tumors, angiogenesis was identified as an important mechanism, demonstrating the possibility of neo-angiogenetic therapy[ 17 ]. There are two case reports using sorafenib in brain metastasis[ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Concurrent hepatocellular carcinoma metastasis to stomach, colon, and brain: A case report

Kim

Song

Kim

2020

WJCC

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BACKGROUND Extrahepatic metastasis (EHM) from hepatocellular carcinoma (HCC) occurs in 10%–15% of cases following initial treatment. The most frequent sites of EHM are the lung, lymph nodes, and bone. Gastrointestinal or brain metastasis from HCC is rarely reported. Here, we report a rare case of concurrent HCC metastases to the stomach, colon, and brain. CASE SUMMARY A 72-year-old male with a history of alcohol induced HCC presented with multiple intrahepatic recurrences and tumorous lesions in the stomach and ascending colon. Three years earlier, he underwent right hemihepatectomy, and 1 year ago, he had a video-assisted thoracoscopic wedge resection for pulmonary metastasis of HCC. We decided on surgical resection of the new metastases because of massive gastric bleeding and concern for possible colonic obstruction. The patient underwent gastric wedge resection and right hemicolectomy. Two weeks later, the patient developed dysarthria and mild cognitive disorder. Magnetic resonance imaging of the brain revealed a left frontal lobe lesion, and he underwent resection of a metastatic brain tumor. Unfortunately, he died 6 weeks after the last surgery due to hepatorenal syndrome. CONCLUSION Decision of surgery was carefully recommended in this case and may extend survival in other metastatic HCC patients with well-preserved hepatic function.

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“…Yeni jenerasyon ALK (anaplastik lenfoma kinaz) inhibitörleri crizotinib, ceritinib, alectinib ve bricatinib ile yapılan çalışmalarda KHDAK'e bağlı beyin metastazlarında umut vaat eden sonuçlar ortaya çıkmıştır (98) . Anjiyogenezis inhibitörü olan bevacizumab beyin metastazlarının tedavisinde etkindir ve ilave olarak peritümöral ödemi kontrol ederek steroid bağımlılığını azaltmaktadır (99) . Son zamanlarda "immün checkpoint inhibitörlerinin" beyin metastazlarının tedavisinde diğer kemoterapatik ajanlarla birlikte kullanıldığında etkili olduğunu gösteren araştırmalar yayınlanmaktadır (100) .…”

Section: Tedaviunclassified

Emergencies in Lung Cancer

Gümüş¹,

Özyurt²

2018

GGHS

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İnsanlarda beklenen ortalama yaşam süresinin artmasıyla birlikte kanser vakalarında da artışlar görülmektedir. Özellikle akciğer kanserinin görülme sıklığı ve mortalitesi dünya çapında artmaya devam etmektedir. Bu hastalarda sıklıkla akut ciddi semptomlar ve yaşamı tehdit eden durumlar ortaya çıkmakta ve acil tıbbi bakım gerekmektedir. Akciğer kanserinde acil servise başvuru ve mortalite diğer solit tümörlerden daha fazla görülmektedir. Bu acil durumlar kanserle direkt veya dolaylı olarak ya da tümörün tedavisi ile ortaya çıkar ve potansiyel olarak yaşamı tehdit eder. Tümörün bölgesel yayılımı ilişkili olarak vena kava süperior sendromu, perikardiyal tamponat, masif hemoptizi, massif plevral efüzyon ve akut hava yolu obstrüksiyonu görülmektedir. Hiperkalsemi, hiponatremi, uygunsuz ADH salınımı sendromu ve tümör lizis sendromu ise akciğer kanserinde ortaya çıkan metabolik acil durumlardır. Beyin metastazları, kemik metastazları ve spinal kord basısı uzak metastazlara bağlı olarak ortaya çıkmaktadır. Ayrıca, bu hastalarda kemoterapiye bağlı olarak febril nötropeni, hipersensitivite reaksiyonları ve anaflaksi, radyoterapiye bağlı olarak akut radyasyon pnömonitisi ve özefajit ortaya çıkmaktadır. Onkolojik aciller hayatı tehtit eder ve mortalitesi yüksektir. Mortalite ve morbiditeyi azaltmak için erken tanı ve tedavi büyük önem taşır. Çünkü tanı ve tedavide gecikmeler çoğu zaman ölümle sonuçlanabilmektedir.

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Anti-angiogenic therapies in brain metastases

Cited by 28 publications

References 28 publications

RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling

RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling

Concurrent hepatocellular carcinoma metastasis to stomach, colon, and brain: A case report

Emergencies in Lung Cancer

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