Anti-annexin A5, Antiphosphatidylinositol Antibodies, and Haematological Parameters in Preeclampsia Patients: A Case-Control Study

Abstract

Background: Prevalence and the risk of common antiphospholipid antibodies (aPLs) such as lupus anticoagulant (LA), anticardiolipin (aCL) and anti-β2-glycoprotein I (β2-GPI) antibodies in preeclampsia is a matter of debate. Recently, interests have expanded in evaluating the risks of presenting non-classic aPLs in preeclampsia patients. Objective: The objective of this case-control study was to evaluate some haematological parameters besides assessing the presence of anti-annexin A5 and antiphosphatidylinositol (aPI) antibodies in preeclampsia patients compared to nonpreeclampsia subjects. Methods: From two hospitals in Malaysia, a total of 84 subjects were recruited in this case-control study including 42 preeclampsia and 42 age-matched non-preeclampsia subjects. Some haematological parameters [i.e., haemoglobin, total white blood cell, platelet, prothrombin time and activated partial thromboplastin time (APTT)] were assessed besides screening for anti-annexin A5 and aPI antibodies. Results: Among the haematological parameters, APTT was significantly high in mild preeclampsia when compared to severe preeclampsia subjects (p=0.007). IgG anti-annexin A5 antibody was detected in a single preeclampsia subject only (2.4%) and none in non-preeclampsia subjects. Conclusion: Because of the low prevalence, non-classic aPLs should not be considered as a risk factor in developing preeclampsia and not justifiable to consider as a routine assay in pregnant women.

Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study

“…These antibodies are the characteristic features of antiphospholipid syndrome associated with thrombosis and/or pregnancy complications [ 12 , 13 ]. Some other non-classical aPLs, such as antiphosphatidylinositol, anti-annexin A5 antiphosphatidylserine, antiphosphatidylethanolamine, and antiprothrombin antibodies, also play a role in the pathogenesis of other diseases [ 14 , 15 ]. The presence of the high titers of aPLs is found in certain medical conditions, including migraine, epilepsy, dementia, Behçet’s disease, systemic lupus erythematosus (SLE), and other autoimmune diseases [ 16 , 17 , 18 , 19 ].…”