Anti-anxiety efficacy of Sudarshan Kriya Yoga in general anxiety disorder: A multicomponent, yoga based, breath intervention program for patients suffering from generalized anxiety disorder with or without comorbidities

Doria, S.; Vuono, A. de; Sanlorenzo, R.; Irtelli, Floriana; Mencacci, Claudio

doi:10.1016/j.jad.2015.06.011

Cited by 71 publications

(79 citation statements)

References 47 publications

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“…The SKY group demonstrated HDRS-17 improvements comparable to IMN and less than ECT. Additional studies of SKY in dysthymic disorder, 12 depression due to alcohol dependence 13 and depression co-morbid with generalized anxiety disorder 27 have demonstrated antidepressant efficacy. Direct comparisons between small studies with different patient populations must be made with caution due to methodological differences.…”

Section: Discussionmentioning

confidence: 99%

A Breathing-Based Meditation Intervention for Patients With Major Depressive Disorder Following Inadequate Response to Antidepressants

Sharma¹,

Barrett²,

Cucchiara³

et al. 2016

J. Clin. Psychiatry

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Objective To evaluate feasibility, efficacy and tolerability of Sudarshan Kriya yoga (SKY) as an adjunctive intervention in patients with major depressive disorder (MDD) with inadequate response to antidepressant treatment. Method Patients with MDD (defined by DSM-IV-TR) depressed despite ≥8 weeks of antidepressant treatment were randomized to SKY or a waitlist control (delayed yoga) arm for 8 weeks. The primary efficacy end point was change in 17-item Hamilton Depression Rating Scale (HDRS-17) total score from baseline to 2 months. The key secondary efficacy end points were change in Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) total scores. Analyses of the intent-to-treat (ITT) and completer sample were performed. The study was conducted at the University of Pennsylvania between October 2014 and December 2015. Results In the ITT sample (n=25), the SKY arm (n=13) showed a greater improvement in HDRS-17 total score compared to waitlist control (n=12)(−9.77 vs. 0.50, P =.0032). SKY also showed greater reduction in BDI total score versus waitlist control (−17.23 vs. −1.75, P = .0101). Mean changes in Beck Anxiety Inventory (BAI) total score from baseline were significantly greater for SKY than waitlist (ITT mean difference: −5.19; 95% CI −0.93 to −9.34; P = .0097; completer mean difference: −6.23; 95% CI −1.39 to −11.07; P = .0005). No adverse events were reported. Conclusion Results of this randomized, waitlist-controlled pilot study suggest the feasibility and promise of an adjunctive SKY-based intervention for patients with MDD who have not responded to antidepressants. Trial Registration ClinicalTrials.gov identifier: NCT02616549

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Section: Discussionmentioning

confidence: 99%

A Breathing-Based Meditation Intervention for Patients With Major Depressive Disorder Following Inadequate Response to Antidepressants

Sharma¹,

Barrett²,

Cucchiara³

et al. 2016

J. Clin. Psychiatry

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“…2 Notably, 45-91% of GAD patients have comorbidities, such as other psychiatric disorders (e.g., panic disorder and major depressive disorder [MDD]) or various other medical conditions, including cardiovascular, gastrointestinal, and respiratory diseases. 3 Diabetes mellitus (DM), which has a global prevalence of 8.3%, is a chronic and disabling disease and is a major cause of lost disability-adjusted life years. 4,5 DM and its complications impose a heavy burden not only on a personal level, but on a global level, i.e., on public health care systems.…”

Section: Introductionmentioning

confidence: 99%

Generalized anxiety disorder in type 2 diabetes mellitus: prevalence and clinical characteristics

Huang

Hsieh

et al. 2020

Braz. J. Psychiatry

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Objective: This study investigated the prevalence of generalized anxiety disorder (GAD) in Taiwanese patients with type 2 diabetes mellitus (T2DM). Methods: This retrospective observational study was conducted with a random sample of patients from the entire population of National Health Insurance enrollees during 2000-2010 and used ICD-9-CM diagnostic codes to identify T2DM patients and GAD. The prevalence of GAD was compared between T2DM patients and the general population. Results: Between 2000 and 2010, the prevalence of GAD was significantly greater in the T2DM patients than the general population, while the increase of GAD was higher in the general population (from 0.25 to 0.63%) than among T2DM patients (from 0.81 to 1.03%). In T2DM patients, GAD was associated with female gender, a Charlson Comorbidity Index X 1, diabetes mellitus duration 4 9 years, and the following comorbidities: congestive heart failure, peripheral vascular disease, and depressive disorder. The prevalence of GAD among T2DM patients was negatively associated with rapid-acting insulin injection therapy and with the use of metformin and sulfonylureas. Conclusion: Since the prevalence of GAD was greater among T2DM patients than the general population, public health initiatives are needed to prevent and treat GAD in T2DM patients, specifically those with the above mentioned risk factors.

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“…Although there is evidence supporting the efficacy of yoga in reducing anxiety in general [26, 27], there are few trials of yoga for GAD, none of which are randomized controlled trials. Of the currently published uncontrolled trials reporting efficacy of yoga for GAD, two employed a yoga breathing intervention [28, 29], one employed a yoga mantra practice [30], and one applied an intervention combining CBT and Kundalini yoga practices [31]. The Kundalini yoga study showed statistically significant improvements in state and trait anxiety, depression, panic, sleep and quality of life with strong effect sizes for state and trait anxiety [31].…”

Section: Introductionmentioning

confidence: 99%

Yoga for generalized anxiety disorder: design of a randomized controlled clinical trial

Hofmann¹,

Curtiss²,

Khalsa³

et al. 2015

Contemporary Clinical Trials

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Generalized anxiety disorder (GAD) is a common disorder associated with significant distress and interference. Although cognitive behavioral therapy (CBT) has been shown to the most effective form of psychotherapy, few patients receive or have access to this intervention. Yoga therapy offers another promising, yet under-researched, intervention that is gaining increasing popularity in the general public, as an anxiety reduction intervention. The purpose of this innovative clinical trial protocol is to investigate the efficacy of a Kundalini Yoga intervention, relative to CBT and a control condition. Kundalini yoga and CBT are compared with each other in a noninferiority test and both treatments are compared to stress education training, an attention control intervention, in superiority tests. The sample will consist of 230 individuals with a primary DSM-5 diagnosis of GAD. This randomized controlled trial will compare yoga (N = 95) to both CBT for GAD (N=95) and stress education (N = 40), a commonly used control condition. All three treatments will be administered by two instructors in a group format over 12 weekly sessions with four to six patients per group. Groups will be randomized using permuted block randomization, which will be stratified by site. Treatment outcome will be evaluated bi-weekly and at 6 month follow-up. Furthermore, potential mediators of treatment outcome will be investigated. Given the individual and economic burden associated with GAD, identifying accessible alternative behavioral treatments will have substantive public health implications.

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Anti-anxiety efficacy of Sudarshan Kriya Yoga in general anxiety disorder: A multicomponent, yoga based, breath intervention program for patients suffering from generalized anxiety disorder with or without comorbidities

Cited by 71 publications

References 47 publications

A Breathing-Based Meditation Intervention for Patients With Major Depressive Disorder Following Inadequate Response to Antidepressants

A Breathing-Based Meditation Intervention for Patients With Major Depressive Disorder Following Inadequate Response to Antidepressants

Generalized anxiety disorder in type 2 diabetes mellitus: prevalence and clinical characteristics

Yoga for generalized anxiety disorder: design of a randomized controlled clinical trial

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