Anti-apolipoprotein A-I (ApoA-I) antibodies have different target epitopes in different clinical conditions

Batuca, Joana R.; Lamy, M; Neves, Marisa; Batista, Frederico; Paiva-Lopes, Ma Joao; Valverde, Ana; Silva, Margarida; McVey, Colin E.; Archer, Margarida; Gonçalves, João; Barbas, Ana; Bandeiras, Tiago M.; Carrondo, Ma Armenia; Alves, José Delgado

doi:10.1016/j.atherosclerosis.2017.06.705

Cited by 4 publications

(6 citation statements)

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“…Evidence shows that chronic inflammation can cause structural protein changes, including creation of neo-epitopes, which, in turn, triggers autoantibody production and HDL alterations. Moreover, patients with an increased cardiovascular risk have elevated levels of autoantibodies against HDLs and apolipoprotein AI [ 29 , 30 ]. These autoantibodies are regarded as biomarkers of cardiovascular diseases among patients with autoimmune disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Anti-aHDL and anti-aApo-AI antibodies were also detected in patients with psoriasis, and their presence correlated with greater disease severity [ 18 ]. Moreover, these autoantibodies could be involved in atherosclerotic plaque development in patients with psoriasis [ 30 , 31 ]. However, among the many lipid alterations observed in psoriasis, it is difficult to distinguish between those specific to psoriasis and those associated with dyslipidemia [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

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Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Pietrzak

Chabros

Grywalska

et al. 2019

aoms

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IntroductionPsoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance. This study assessed blood parameters of lipid metabolism and markers of oxidative stress in patients with psoriasis and PSA.Material and methodsThe study included 93 patients with psoriasis (31 patients with PSA and psoriasis, 62 patients with psoriasis vulgaris), and 60 healthy, age-matched controls. Serum concentrations of the glucose and the following lipid metabolism parameters were measured: triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), high-density lipoproteins (HDL), and apolipoproteins A and B (ApoA, ApoB). Oxidative status was determined as serum concentrations of ox-LDL/MDA Adduct. The Psoriasis Area and Severity Index (PASI) was used to determine disease severity.ResultsAmong the three studied groups, controls had the highest HDL concentration (p < 0.001), patients with PSA had the highest ApoB concentration (p < 0.05), ApoA : ApoB ratio (p < 0.05), ox-LDL/MDA adduct concentration (p < 0.001), and TC: HDL and LDL : HDL ratios (accordingly p < 0.05, p < 0.01). In patients with psoriasis or PSA, oxidative status correlated positively with TC and ApoB concentrations.ConclusionsIn line with previous research, among patients with psoriasis and PSA, we found lipid metabolism abnormalities and an oxidative imbalance, which might be due to chronic inflammation in these conditions. Effective treatment of patients with psoriasis or PSA could reduce the risk of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Pietrzak

Chabros

Grywalska

et al. 2019

aoms

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“…Batuca et al found that elevated levels of autoantibodies were related with an increased cardiovascular risk and they could be involved in the development of atherosclerotic plaques. 12 These antibodies were also detected in patients with other autoimmune disease and their presence correlated with the severity of disease. 13 The previous studies reported that the vitamin D deficiency may be associated with dyslipidaemia in apparently healthy people and in diabetic patients.…”

Section: Discussionmentioning

confidence: 96%

The role of high-dose vitamin D supplementation on disease severity and lipid profile in psoriatic patients: A pilot study

Prtina¹,

Grabež²,

Vujnic³

et al. 2020

Scripta Medica

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Background/Aim: Psoriasis is a chronic inflammatory skin disease that is associated with a higher prevalence of cardiovascular (CV) risk factors. The effect of vitamin D on bone health has been long known, but its extraskeletal role especially in cardiovascular disease and skin disease, is the subject of recent research. This study aimed to assess the influence of high-dose vitamin D supplementation on the Psoriasis Area and Severity Index (PASI) score and lipid profile in patients with psoriasis. Methods: The study included 20 adult patients with chronic plaque psoriasis. They received vitamin D capsules in a daily dose of 5,000 IU over 12 weeks. Measured serum concentrations of lipid metabolism parameters were triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL) and high-density lipoproteins (HDL). PASI was used to determine the severity of the disease. Results: High-doses vitamin D supplementation had a significant influence on reduction in PASI score in all patients (17.99 ± 12.42 vs 10.27 ± 8.53; p < 0.001). The supplementation of high dose vitamin D induced statistically significant lowering of the TC, LDL-C and TG in the psoriatic patients (p < 0.05). Furthermore, significant increase in serum HDL-C level was observed. The change of PASI score showed week positive correlation with the changes in serum TC and LDL-C (r = 0.303, p = 0.03 and r = 0.357 p = 0.013). Conclusion: High-dose vitamin D supplementation had a positive impact on clinical status of the chronic plaque psoriasis patients, measured by PASI score. It also improved the serum lipid profile of these patients. Double-blinded prospective studies are needed in order to get more comprehensive data related to vitamin D, lipid metabolism and severity of psoriasis.

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“…Этот феномен получил название «липидный парадокс», поскольку низкий уровень ОХС и ХС ЛПНП ассоциировался с увеличением сердечно-сосудистого риска [17]. Воспаление не только меняет уровень сывороточных липидов, но и приводит к проатерогенным изменениям в липидном профиле -образованию окисленных форм ЛПНП, выработке аутоантител к ЛПВП и АпоA-I [29]. В нашем исследовании риск развития фатальных ССЗ по шкале SCORE был низким в 62% случаев, даже у пациентов с нецелевыми показателями ОХС, ХС ЛПНП, ХС ЛПВП, КА и ТГ.…”

Section: Discussionunclassified

“…Не ясно, является ли хроническое воспаление причиной или следствием нарушений липидного обмена. Продолжается изучение потенциальных механизмов, которые могут лежать в основе ассоциации между ПсА и ССЗ, включая воспаление, секрецию адипокинов, инсулинорезистентность, структуру и функцию липопротеинов, ангиогенез, окислительный стресс [10,29,32,33].…”

Section: Discussionunclassified