Anti-Apoptotic Effect of Hyperbaric Oxygen Preconditioning on a Rat Model of Myocardial Infarction

Sun, Qiang; Sun, Qing Wen; Liu, Yun; Sun, Xuejun; Tao, Hengyi

doi:10.1016/j.jss.2010.01.036

Cited by 14 publications

(10 citation statements)

References 27 publications

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“…In the majority of these tissues the final 3NT levels were higher in the diabetic mice compared with the control group. This difference coincided with a positive correlation between the final levels of GSH and NO in all tissues in the diabetic mice only, contradicting the known effect of NO on the synthesis of GSH in rodent tissues without diabetes (24,53) which was also observed in the control group in the present study.…”

Section: Discussioncontrasting

confidence: 84%

“…Studies have described the protective effect of HBO pre-treatment against oxidative stress produced by distinct factors in different animal models, including experimental damage to the rat spinal cord (27), cerebral ischemia-reperfusion (28), experimental myocardial infarct (53), and the effect of ultraviolet light on mouse skin and liver (29). HBO pretreatment is also reported to reduce the levels of indicators of oxidative stress in rat thoracic aorta, including NO (31) and to decrease oxidative stress in rat lungs (30).…”

Section: Discussionmentioning

confidence: 99%

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Alterations in glutathione, nitric oxide and 3‑nitrotyrosine levels following exercise and/or hyperbaric oxygen treatment in mice with diet‑induced diabetes

et al. 2020

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Oxidative stress is involved in the development of diabetes. Nitric oxide (NO) contributes to oxidative stress, affects the synthesis of glutathione (GSH) in tissues and also regulates important physiological processes. The levels of nitrosative stress, assessed by measuring the levels of 3-nitrotirosina (3NT) as well as the bioavailability of NO are modulated by exercise and hyperbaric oxygenation (HBO). The aim of the present study was to evaluate the effects of exercise and HBO on the levels of NO, 3NT and GSH in tissues of various organs obtained from diabetic mice. Female mice were fed a high-fat/high-fructose diet to induce diabetes. Mice with diabetes were subjected to exercise and/or HBO. Initial and final concentrations of NO, 3NT and GSH were assessed in the muscle, liver, kidney, heart, spleen, lung, brain, visceral adipose, thoracic aorta and small intestine. Diabetes did not affect initial values of NO, although it significantly increased the levels of 3NT. The basal level of GSH in the diabetic group was lower than or comparable to that of the control group in the majority of the organs assessed. A negative correlation was observed between 3NT and GSH levels in the initial values of all tissues of the control group only, whereas all pathological tissues showed a positive correlation between NO and GSH. There was an increase or a stabilization of GSH levels in the majority of the organs in all treated mice despite the increase in nitrosative stress.

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Section: Discussioncontrasting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Alterations in glutathione, nitric oxide and 3‑nitrotyrosine levels following exercise and/or hyperbaric oxygen treatment in mice with diet‑induced diabetes

et al. 2020

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“…Oxygen increases expression of antioxidant enzymes in both tissues and plasma via an increase in glutathione levels . This reduces the degree of lipid peroxidation and prevents neutrophil activation in response to endothelial damage, thereby modifying ischaemia–reperfusion injury and providing anti‐apoptotic effects . The common factor is likely to be induction of protective mechanisms via a lesser degree of oxidative stress .…”

Section: Effects Of Hbomentioning

confidence: 99%

The medical use of oxygen: a time for critical reappraisal

2013

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“…It has also been reported that HBOT increases the production of reactive oxygen species (ROS) within the tissue (Matsunami et al 2011;Simsek et al 2011), thereby mobilizing cellular antioxidant responses (Matsunami et al 2009;Godman et al 2010b;He et al 2011). Accordingly, hyperbaric oxygen (HBO) has been acknowledged as an effective preconditioning agent under circumstances in which protection from oxidative damage is desired, such as in rat models of myocardial infarction (Han et al 2008;Sun et al 2011) and cerebral ischemia-reperfusion injury Cheng et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen preconditioning protects skin from UV-A damage

Fuller

Giardina

Hightower

et al. 2013

Cell Stress and Chaperones

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Hyperbaric oxygen therapy (HBOT) is used for a number of applications, including the treatment of diabetic foot ulcers and CO poisoning. However, we and others have shown that HBOT can mobilize cellular antioxidant defenses, suggesting that it may also be useful under circumstances in which tissue protection from oxidative damage is desired. To test the protective properties of hyperbaric oxygen (HBO) on a tissue level, we evaluated the ability of a preconditioning treatment regimen to protect cutaneous tissue from UV-A-induced oxidative damage. Three groups of hairless SKH1-E mice were exposed to UV-A 3 days per week for 22 weeks, with two of these groups receiving an HBO pretreatment either two or four times per week. UV-A exposure increased apoptosis and proliferation of the skin tissue, indicating elevated levels of epithelial damage and repair. Pretreatment with HBO significantly reduced UV-A-induced apoptosis and proliferation. A morphometric analysis of microscopic tissue folds also showed a significant increase in skin creasing following UV-A exposure, which was prevented by HBO pretreatment. Likewise, skin elasticity was found to be greatest in the group treated with HBO four times per week. The effects of HBO were also apparent systemically as reductions in caspase-3 activity and expression were observed in the liver. Our findings support a protective function of HBO pretreatment from a direct oxidative challenge of UV-A to skin tissue. Similar protection of other tissues may likewise be achievable.

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Anti-Apoptotic Effect of Hyperbaric Oxygen Preconditioning on a Rat Model of Myocardial Infarction

Cited by 14 publications

References 27 publications

Alterations in glutathione, nitric oxide and 3‑nitrotyrosine levels following exercise and/or hyperbaric oxygen treatment in mice with diet‑induced diabetes

Alterations in glutathione, nitric oxide and 3‑nitrotyrosine levels following exercise and/or hyperbaric oxygen treatment in mice with diet‑induced diabetes

The medical use of oxygen: a time for critical reappraisal

Hyperbaric oxygen preconditioning protects skin from UV-A damage

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