Anti-arthritic and anti-inflammatory activity of combined pioglitazone and prednisolone on adjuvant-induced arthritis

Suke, Sanvidhan G.; Negi, Harsh; Mediratta, Pramod Kumari; Banerjee, B. D.; Sharma, Krishna K.

doi:10.1016/j.ejphar.2013.09.019

Cited by 28 publications

(26 citation statements)

References 34 publications

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“…To date, information regarding the efficacy of prednisone in arthritis treatment is well documented (Townsend and Saag 2004). Results from this study were also consistent to the results previously obtained from treatment of arthritic rats with prednisone as previously reported (Rioja et al 2004;Suke et al 2013).…”

Section: Fig 5 Effects Of Age On Oxidative Stress Index Levelssupporting

confidence: 93%

Apium GraveolensExtract Attenuates Adjuvant Induced Arthritis by Reducing Oxidative Stress

Choosri

Tanasawet

Chonpathompikunlert

et al. 2016

Journal of Food Biochemistry

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The purpose of this study was to investigate the effects of an Apium graveolens extract (AGE) on the arthritis in rats induced using Complete Freund's adjuvant (CFA). Arthritis was induced by injecting CFA into the subplantar of the left hind paws. The AGE (250, 500, 1000 mg/kg) and prednisone 10 mg/kg were given orally at day 5 to day 28 after induction. Treatment of AGE significantly attenuated the severity of CFA-induced arthritis and decreased the arthritis score, paw and ankle thickness. Any histopathological changes were noted. The plasma levels of total peroxide (TP) and oxidative stress index (OSI) were significantly decreased by oral administration of AGE as well as the total antioxidant status (TAS) was significantly increased. Furthermore, oral administrations of AGE remarkably attenuated the increased nitric oxide (NO) levels after induction as was also the myeloperoxidase (MPO) activity in plasma of CFA-induced arthritic rats. PRACTICAL APPLICATIONSApium graveolens Linn has been consumed as food and traditionally used for inflammatory diseases, gout and rheumatic condition. However, there is no report for pharmacological activity of A. graveolens in the treatment of arthritis. Our results indicate that A. graveolens could alleviate CFA-induced arthritis in rats by decreasing the level of TP, OSI, NO and MPO activity as well as by increasing the level of TAS. Insights from our study may provide the beneficial uses of A. graveolens as a functional food and nutraceutical development for the treatment of rheumatoid arthritis.

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Section: Fig 5 Effects Of Age On Oxidative Stress Index Levelssupporting

confidence: 93%

Apium GraveolensExtract Attenuates Adjuvant Induced Arthritis by Reducing Oxidative Stress

Choosri

Tanasawet

Chonpathompikunlert

et al. 2016

Journal of Food Biochemistry

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“…Therefore, new drugs are needed with better efficacy and tolerability for pulmonary fibrosis that complicates RA [7] . Recently, researchers are directed towards traditional system of medicine for the discovery of drugs with minimal side effects [8,9] . Furthermore, over the past several years evidence has been growing on the benefits of dietary fats on bone health.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the possible therapeutic role of omega-3 on ankle joint and lung in a model of rheumatoid arthritis in rats: A histological and immunohistochemical study

Raafat¹,

Hamam²,

Farhan

et al. 2018

Egyptian Journal of Histology

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Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory systemic autoimmune disease. Lung disease has been recognized as a common complication of RA. Omega-3 is an essential fatty acid with wide range of activity. Aim of the work: To investigate the possible therapeutic role of omega-3 free fatty acid on the structure of ankle joint and lung in a model of adjuvant-induced RA in rats. Materials and Methods: Thirty adult male albino rats were divided into three groups; Group I served as a control group. Group II was used as a model of RA. Rats of this group were given single subcutaneous injection of 0.1ml of complete Freund adjuvant in their hind paws. Group III (omega 3-treated group), omega-3 was given in as a dose of 300 mg/kg orally administered after two weeks of RA induction and continued daily for another two weeks. The ankle joint and the lungs from all groups were dissected out after two and four weeks and processed for light microscopic examination. Histomorphometric studies and statistical analysis were also done. Results: RA was confirmed histologically in the ankle joint after two weeks and was aggravated after four weeks. Erosion of articular cartilage and mononuclear cellular infiltration in the synovium were noticed in both time points. Moreover, the lungs after two weeks showed focal inflammatory cellular infiltration and pulmonary fibrosis that were more evident after four weeks of untreated RA. This was associated with significant increase in the mean area percentage of collagen fibers and number of cells positive for TNF-α immunohistochemical reaction compared to the control group. Omega-3 treated group illustrated improvement of both ankle and lung structures. Conclusion: Omega-3 significantly ameliorated the structural damage of ankle joint and lung after RA induction.

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“…Complete Freund's Adjuvant (CFA) obtained from dried Mycobacteria is a well-documented inducer for RA experimentally (Suke et al, 2013;Huang et al, 2014;Miao et al, 2015). Historically, Pearson (1956) concluded that CFA-induced arthritis is a chronic auto-immune condition.…”

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confidence: 99%

Ramipril and haloperidol as promising approaches in managing rheumatoid arthritis in rats

Wahba

Messiha

Abo-Saif

2015

European Journal of Pharmacology

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Anti-arthritic and anti-inflammatory activity of combined pioglitazone and prednisolone on adjuvant-induced arthritis

Cited by 28 publications

References 34 publications

Apium GraveolensExtract Attenuates Adjuvant Induced Arthritis by Reducing Oxidative Stress

Apium GraveolensExtract Attenuates Adjuvant Induced Arthritis by Reducing Oxidative Stress

Evaluation of the possible therapeutic role of omega-3 on ankle joint and lung in a model of rheumatoid arthritis in rats: A histological and immunohistochemical study

Ramipril and haloperidol as promising approaches in managing rheumatoid arthritis in rats

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