Anti-arthritic and Safety Pharmacological Effects of Gum Extract from Anacardium occidentale in Rats

Silva, Daiany Priscilla Bueno da; Florentino, Iziara Ferreira; Moreira, Lorrane Kelle da Silva; Cardoso, Carina Sofia; Fajemiroye, James Oluwagbamigbe; Ghedini, Paulo César; Godoi, Murion Monteiro de; Santos, Fernanda C. A.; Batista, Karla de Aleluia; Pereira-Júnior, Marcos A.; Fernandes, Kátia Flávia; Vaz, Boniek Gontijo; Ferreira, Marcos Roberto Alves; Costa, Élson Alves

doi:10.1007/s43450-021-00135-8

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…These compounds include Aspidofractinine-3-methanol, Phthalic acid 2ethylhexyl tetradecyl ester, Phthalic acid di(2propyl pentyl) ester, 9-(2',2'-Dimethylpropanoyl hydrazono)-3,6-dichloro-2,7-bis-[2-diethyl amino)ethoxy]fluorine, Terephthalic acid, and dodecyl 2-ethylhexyl ester [12]. Some members of the Anacardiaceae family have been known to show activity against RA such as Anacardium occidentale [13],…”

Section: Introductionmentioning

confidence: 99%

In vitro radical scavenging and in vivo antiarthritic effects of Spondias mombin (L.) stem bark

Adekanmi,

Oguchukwu,

Tolani

et al. 2023

J. Pharm Bio.

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Rheumatoid arthritis (RA) is a systemic autoimmune disorder that affects about 1% of the population globally. Numerous conventional medications are available for the management of RA. However, their usage is limited due to the associated side effects. Spondias mombin is a member of the Anacardiaceae family known for its anti-arthritic effects. This study aimed to evaluate the anti-arthritic activity of S. mombin (L.) stem bark in RA. Radical scavenging activity was determined using DPPH assay. The anti-inflammatory effect was determined using protease inhibition and formaldehyde-induced arthritis models. S. mombin aqueous fraction (SMAF) exhibited a significant (p<0.0001) radical scavenging effect (IC50 of 57.87 µg/mL) over the S. mombin methanol extract (SMME) and S. mombin chloroform fraction (SMCF) when compared to the sham control. SMAF at 500 µg/mL significantly (p<0.05) inhibited (56.89 ± 2.02%) the effect of protease when compared to the sham control. SMME significantly (p<0.001) reduced inflammation in rat paws when compared to the control with peak effects seen at the dose of 50 mg/kg body weight. The result of the study has revealed that the stem bark has radical scavenging and anti-inflammatory effects.

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Section: Introductionmentioning

confidence: 99%