Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats

Mbiantcha, Marius; Jabeen, Almas; Simjee, Shabana Usman; Dastagir, Nida; Faheem, Aisha

doi:10.1186/s12906-017-1623-5

Cited by 61 publications

(44 citation statements)

References 77 publications

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“…Results indicated that when taken the test extract daily can protect the body against inflammation and also used to treat an inflammatory condition. Results are in accordance with report by Mbiantcha et al [17].…”

Section: Resultssupporting

confidence: 93%

Studies on Hepatoprotective and Anti-Inflammatory Activity of Coix Lacryma–jobi (Linn)

Geetha

Firdous

Karpagam

et al. 2018

Asian J Pharm Clin Res

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Objective: In the present study, evaluation of hepatoprotective activity of Coix lacryma-jobi by CCl4-induced hepatotoxicity test, and evaluation of anti-inflammatory activity of by egg albumin-induced paw edema, and complete Freund’s adjuvant-induced arthritis model were done.Methods: Plant extract was prepared by mixing ethanol with powdered plant seeds and experiment was done as per the procedures of above-mentioned three models.Results: C. lacryma-jobi test extracts out of two doses, 400 mg/kg exhibited a significant reduction in serum cholesterol level as 33 mg/dl when compared to control groups. C. lacryma-jobi seed extract has restored various serological alterations following CCl4-induced hepatotoxicity and was capable of reversing the toxic effects of CCl4 on liver cells. Considerable reduction in the paw volume of exudates observed with C. lacryma-jobi extract, indicating significant anti-inflammatory activity.Conclusion: Therefore, this study shows that C. lacryma-jobs seed extract have anti-inflammatory activity in the models studied.

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Section: Resultssupporting

confidence: 93%

Studies on Hepatoprotective and Anti-Inflammatory Activity of Coix Lacryma–jobi (Linn)

Geetha

Firdous

Karpagam

et al. 2018

Asian J Pharm Clin Res

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“…et al . (1982) 45,46 . In this experiment all the compounds were evaluated at 25 µg/mL, each in triplicate.…”

Section: Discussionmentioning

confidence: 99%

Studies on Isoniazid Derivatives through a Medicinal Chemistry Approach for the Identification of New Inhibitors of Urease and Inflammatory Markers

Rizvi

Khan

Jabeen

et al. 2019

Sci Rep

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A library of thiosemicarbazide derivatives of isoniazid 3–27 , was synthesized and evaluated for their anti-inflammatory and urease inhibition activities, by using in vitro bioassays. Among these compounds 9 , 10 , 12 , 21 , and 26 were identified as new derivatives. Prolonged use of non-steroidal anti-inflammatory drugs (NSAIDs) and infections caused by Helicobacter pylori (ureolytic bacteria), are the two most significant causes of gastric and peptic ulcers. We focused on the identification of the dual inhibitors of inflammation and urease enzyme. Compound 23 was identified as the best dual inhibitor of inflammation (ROS; IC 50 = 12.3 µg/mL), and urease enzyme inhibition activity (IC 50 = 22.4 µM). Many of these compounds showed comparable activities to the standard anti-inflammatory drug (ibuprofen, IC 50 = 11.2 µg/mL) and urease inhibitor (thiourea/acetohydraoxamic acid, IC 50 = 21.1/20.3 µM). Compound 12 was found to be the most potent urease inhibitor (IC 50 = 12.3 µM) and good inhibitor of inflammation (IC 50 = 27.7 µg/mL). Compounds 19 , 11 , 13 , 9 , 17 , 10 , and 16 , were also found to be potent inhibitors of urease. Cytotoxicity was also evaluated and all the compounds were found to be non-cytotoxic, except compound 18 and the parent drug isoniazid (IC 50 = 29.5 and 28.5 µM, respectively).

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“…The CFA-induced arthritis model in experimental animals signify chronic inflammation involving several systemic changes along with synovial hyperplasia [154]. It results from massive leukocytes infiltration, increase in chemokine and cytokine levels including IL-1β and TNF-α, release of ROS, cartilage and bone destruction, along with swelling and deformation [154,155,156]. CFA injection into the footpad of rat causes swelling of periarticular tissues like ligaments and joint capsules.…”

Section: Anti-inflammatory Drug Development From Natural Products:mentioning

confidence: 99%

Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals

Patil

Mahajan

Unger³

et al. 2019

IJMS

261

175

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Inflammation is one of the common events in the majority of acute as well as chronic debilitating diseases and represent a chief cause of morbidity in today’s era of modern lifestyle. If unchecked, inflammation leads to development of rheumatoid arthritis, diabetes, cancer, Alzheimer’s disease, and atherosclerosis along with pulmonary, autoimmune and cardiovascular diseases. Inflammation involves a complex network of many mediators, a variety of cells, and execution of multiple pathways. Current therapy for inflammatory diseases is limited to the steroidal and non-steroidal anti-inflammatory agents. The chronic use of these drugs is reported to cause severe adverse effects like gastrointestinal, cardiovascular, and renal abnormalities. There is a massive need to explore new anti-inflammatory agents with selective action and lesser toxicity. Plants and isolated phytoconstituents are promising and interesting sources of new anti-inflammatories. However, drug development from natural sources has been linked with hurdles like the complex nature of extracts, difficulties in isolation of pure phytoconstituents, and the yield of isolated compounds in minute quantities that is insufficient for subsequent lead development. Although various in-vivo and in-vitro models for anti-inflammatory drug development are available, judicious selection of appropriate animal models is a vital step in the early phase of drug development. Systematic evaluation of phytoconstituents can facilitate the identification and development of potential anti-inflammatory leads from natural sources. The present review describes various techniques of anti-inflammatory drug screening with its advantages and limitations, elaboration on biological targets of phytoconstituents in inflammation and biomarkers for the prediction of adverse effects of anti-inflammatory drugs. The systematic approach proposed through present article for anti-inflammatory drug screening can rationalize the identification of novel phytoconstituents at the initial stage of drug screening programs.

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Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats

Cited by 61 publications

References 77 publications

Studies on Hepatoprotective and Anti-Inflammatory Activity of Coix Lacryma–jobi (Linn)

Studies on Hepatoprotective and Anti-Inflammatory Activity of Coix Lacryma–jobi (Linn)

Studies on Isoniazid Derivatives through a Medicinal Chemistry Approach for the Identification of New Inhibitors of Urease and Inflammatory Markers

Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals

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