Anti-Atopic Activity of Tuna Heart Ethanol Extract

강보경,; 김꽃봉우리,; 김민지,; 박시우,; 박원민,; 김보람,; 안나경,; 최연욱,; 배난영,; 박지혜,; 안동현,

doi:10.3746/jkfn.2015.44.1.001

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…However, the processing of marine products, such as tuna generates 30–35% byproducts of total materials ( 32 ). Recently, certain studies have been conducted in order to take advantage of fishery by-products since they contain a variety of functional proteins ( 20 ). Typically, tuna is a high-protein food which exerts anti-atherosclerotic and anticancer effects, and is known to protect against high cholesterol levels in the blood ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

“…Typically, tuna is a high-protein food which exerts anti-atherosclerotic and anticancer effects, and is known to protect against high cholesterol levels in the blood ( 18 ). Thus, the present study was conducted on tuna waste, and previous studies reported on the anti-obesity effects of boiled tuna extract on 3T3-L1 cells ( 18 , 19 ) and the anti-atopic effect of an ethanol extract of tuna heart ( 20 ). However, bioactivity studies using tuna heart are not common.…”

Section: Discussionmentioning

confidence: 99%

“…Omega-3 fatty acid separated through protein hydrolysate, and concentrates of its by-products, has previously been used in the food and pharmaceutical industries ( 15 – 17 ). Studies on immune enhancement and on unsaturated fats in tuna by-products have previously been performed ( 18 – 20 ). In this study, we examined the anti-wrinkle effects of a physiologically active substance isolated from tuna heart extract on skin by measuring the expression levels MMPs in skin fibroblasts and determining whether they are directly involved in the anti-wrinkle effects.…”

Section: Introductionmentioning

confidence: 99%

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Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Kim

Jung

Choi

et al. 2015

International Journal of Molecular Medicine

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With the increase in life expectancy, there is also growing interest in anti-aging treatments and technologies. The development of anti-aging functional drugs for the skin, and foods from natural sources, may offer solutions to this global matter. Aging involves structural, functional and biochemical changes that occur throughout cells and bodily tissues; the amount of hormones secreted from of all human organs, including the skin, decreases over time. Matrix metalloproteinase (MMP) genes (MMP-1 and -8) play an important role in the aging of skin fibroblasts. For example, an increased MMP expression causes accelerated aging and the degradation of skin elasticity-related genes. In the present study, we examined the anti-wrinkle effects of tuna heart extract which are mediated through the inhibition of MMPs in skin cells. Generally, tuna contains high concentrations of selenium and antioxidants, which serve to remove free radicals, and is known to delay skin and body aging. In addition, unsaturated fatty acids in tuna help to maintain the natural glossy look of skin, and increase skin elasticity, providing moisture for dry skin. A recent study confirmed the various bio-effects of boiled tuna extract and muscle. However, bioactivity studies using tuna heart are limited. Thus, in the present study, we obtained extracts and fractions of tuna heart, and examined their effects on Hs27 human fibroblast proliferation using an MTS assay. In addition, we measured procollagen type 1 levels and elastase activity, and performed β-galactosidase staining. We then measured the expression levels of phosphatidylinositol 3-kinase/Akt and MMP-related genes by western blot analysis and RT-PCR. Our results revealed that tuna heart extract decreased MMP expression by upregulating tissue inhibitors of metallopro-teinase-1 (TIMP-1) and decreasing elastase activity, thus exerting anti-aging and anti-wrinkle effects by increasing collagen synthesis and promoting skin fibroblast proliferation. Thus, our data suggest that tuna heart (TH)-H2O fractions exert anti-wrinkle effects on Hs27 cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Kim

Jung

Choi

et al. 2015

International Journal of Molecular Medicine

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“…The Th2 cytokines IL-5 and IL-4 take an role in AD by increasing IgE production and eosinophils [ 3 ]. The alleviating effect of red corn extract on AD in DNCB-induced mice [ 5 ] and the anti-atopic activity of ethanol extract from tuna heart [ 6 ] that produce decreased IFN-γ and enhanced proportion of allergen-specific T cells associated with increased IL-5 and IL-4 have been reported in peripheral blood smears of AD patients. The cause of atopy is not yet known, but genetic, immunological , and environmental factors are known to predispose patients to this disorder [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Atopic Activities of Sargassum horneri Hot Water Extracts in 2,4-Dinitrochlorobezene-Induced Mouse Models

Woo

Hwang

Park

et al. 2023

J. Microbiol. Biotechnol.

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Atopic dermatitis (AD) is a chronic inflammation associated with skin hypersensitivity caused by environmental factors. The objent of this study was to assess the hot water extracts of Sargassum horneri (SHHWE) on AD. AD was induced by spreading 2,4-dinitrochlorobenzene (DNCB) on the BALB/c mice. The efficacy of SHHWE was tested by observing the immunoglobulin E (IgE), cytokine, skin clinical severity score and cytokine secretions in concanavalin A (Con A)-stimulated splenocytes. The levels of interleukine (IL)-4, IL-5 and IgE, the pro-inflammatory cytokines that are closely related, were notably suppressed in a does-dependent manner by SHHWE, whereas the level of interferon γ (IFN-γ), the atopy-related Th1 cytokine inhibiting the production of Th2 cytokines, was increased. Therefore, these results show that SHHWE has a potent anti-inhibitory effect on AD and is highly valuable for cosmetic development.

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“…Although these drugs may relieve certain symptoms, long-term use of topical steroids may additionally lead to thinning of the skin with subsequent bleeding (5,6). Therefore, a number of ongoing studies are attempting identify functional substances from safe and effective natural products to prevent AD without side effects (7,8).…”

Section: Introductionmentioning

confidence: 99%

Anti‑inflammatory effects of Dendropanax�morbifera in lipopolysaccharide‑stimulated RAW264.7 macrophages and in an animal model of atopic dermatitis

Choo

Lim²,

Kim³

et al. 2019

Mol Med Report

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Dendropanax morbifera ( D. morbifera ), known as Dendro, means ‘omnipotent drug’ (Panax), and has been called the panacea tree. Various studies on D. morbifera are currently ongoing, aiming to determine its medicinal uses. The present study investigated the anti-inflammatory effects and underlying mechanism of a natural extract of D. morbifera leaves (DPL) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In the present study, the following assays and models were used: MTT assay, nitric oxide (NO) assay, western blotting, ELISA and mouse models of atopic dermatitis. DPL extract markedly reduced the production of NO, inducible NO synthase and interleukin-6, as well as the nuclear translocation of nuclear factor-κB (NF-κB). Additionally, the LPS-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2), P38 and c-Jun N-terminal kinase (JNK) was suppressed by DPL extract. Taken together, these results indicate that NF-κB, ERK1/2, P38 and JNK may be potential molecular targets of DPL extract in the LPS-induced inflammatory response. Subsequently, the present study investigated the effects of DPL extract in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model. Ear thickness, serum immunoglobulin E levels and histological analysis revealed that the DPL extract was effective in attenuating the inflammatory response. These results indicate that DPL extract has anti-inflammatory potential and may be developed as a botanical drug to treat atopic dermatitis.

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Anti-Atopic Activity of Tuna Heart Ethanol Extract

Cited by 7 publications

References 16 publications

Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Anti-Atopic Activities of Sargassum horneri Hot Water Extracts in 2,4-Dinitrochlorobezene-Induced Mouse Models

Anti‑inflammatory effects of Dendropanax�morbifera in lipopolysaccharide‑stimulated RAW264.7 macrophages and in an animal model of atopic dermatitis

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