Anti-Atopic Dermatitis of Purified Bee Venom on Keratinocytes Via Suppression of PAR2, ICAM-1, and IL-6 Expression

Han, Sang Mi; Kim, Se Gun; Jang, Hye Ri; Woo, Soon Ok; Pak, Sok Cheon

doi:10.2478/jas-2018-0016

Journal of Apicultural Science

2018

DOI: 10.2478/jas-2018-0016

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Anti-Atopic Dermatitis of Purified Bee Venom on Keratinocytes Via Suppression of PAR2, ICAM-1, and IL-6 Expression

Sang Mi Han

Se Gun Kim

Hye Ri Jang

et al.

Abstract: Emerging evidence indicates that inflammation in atopic dermatitis (AD) is associated with immune-mediated abnormalities in the skin. The history and severity of AD are risk factors for dust mite allergy. Bee venom (BV) is used in a complementary medicine to treat various diseases and skin disorders. Purified BV is obtained through electric stunning with a BV collector, without the harming of honeybees, followed by the removal of impurities from the collected BV and lyophilization of the final product. To eval… Show more

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2022

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Cited by 2 publications

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Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

Shi

Xie²,

Yang³

et al. 2022

Front. Pharmacol.

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Bee venom (BV), a type of defensive venom, has been confirmed to have favorable activities, such as anti-tumor, neuroprotective, anti-inflammatory, analgesic, anti-infectivity effects, etc. This study reviewed the recent progress on the pharmacological effects and mechanisms of BV and its main components against cancer, neurological disorders, inflammatory diseases, pain, microbial diseases, liver, kidney, lung and muscle injury, and other diseases in literature during the years 2018–2021. The related target proteins of BV and its main components against the diseases include Akt, mTOR, JNK, Wnt-5α, HIF-1α, NF-κB, JAK2, Nrf2, BDNF, Smad2/3, AMPK, and so on, which are referring to PI3K/Akt/mTOR, MAPK, Wnt/β-catenin, HIF-1α, NF-κB, JAK/STAT, Nrf2/HO-1, TrkB/CREB/BDNF, TGF-β/Smad2/3, and AMPK signaling pathways, etc. Further, with the reported targets, the potential effects and mechanisms on diseases were bioinformatically predicted via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, disease ontology semantic and enrichment (DOSE) and protein-protein interaction (PPI) analyses. This review provides new insights into the therapeutic effects and mechanisms of BV and its main components on diseases.

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Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

Shi

Xie²,

Yang³

et al. 2022

Front. Pharmacol.

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show abstract

Scabicidal Potential of Coconut Seed Extract in Rabbits via Downregulating Inflammatory/Immune Cross Talk: A Comprehensive Phytochemical/GC-MS and In Silico Proof

et al. 2022

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Scabies is an invasive skin condition caused by Sarcoptes scabiei mites. The present study investigates the antiscabies potential of coconut seed extract (CSE) in rabbits. GC-MS analysis of the seed oil identified 17 known compounds, while CSE phytochemical investigation afforded 4 known ones. The topical application of seed extract improved all signs of infection, and the improvement started 3 days post application. However, in vitro application of the extract caused 99% mortality of mites 1 day post application. Histopathological examination revealed the absence of inflammatory infiltration and hyperkeratosis of the epidermis, compared with ivermectin-treated groups which revealed less improvement. The mRNA gene expression results revealed a suppression of IL-1β, IL-6, IL-10, MMP-9, VEGF, and MCP-1, and an upregulation of I-CAM-1, KGF as well as TIMP-1. The docking analysis emphasized a strong binding of gondoic acid with IL-1β, IL-6, and VEGF with high binding scores of −5.817, −5.291, and −8.362 kcal/mol, respectively, and a high binding affinity of 3″(1‴-O-β-D-glucopyranosyl)-sucrose with GST with −7.24 kcal/mol. Accordingly, and for the first time, our results highlighted the scabicidal potential of coconut seed extract, which opens the gate for an efficient, cost-effective as well as herbal-based alternative for the control of scabies in rabbits.

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Anti-Atopic Dermatitis of Purified Bee Venom on Keratinocytes Via Suppression of PAR2, ICAM-1, and IL-6 Expression

Cited by 2 publications

References 17 publications

Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

Scabicidal Potential of Coconut Seed Extract in Rabbits via Downregulating Inflammatory/Immune Cross Talk: A Comprehensive Phytochemical/GC-MS and In Silico Proof

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