Anti b-Glucan Antibody in Cancer Patients (Preliminary Report)

Motoi, Masuro; Ishibashi, Keiichiro; Mizukami, Osamu; Miura, Noriko N.; Adachi, Yoshiyuki; Ohno, Naohito

doi:10.1615/intjmedmushr.v6.i1.40

Cited by 6 publications

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“…These facts strongly suggested that pharmacological action of cold water extract differ from that of hot water extract. We have also shown that the cold water extract contains enzymes such as polyphenol oxidase and peroxidase ( 19–25 ). Table 1 shows the general constituents of A. brasiliensis KA21.…”

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confidence: 99%

Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers

Liu¹,

Fukuwatari²,

Okumura

et al. 2007

Evidence-Based Complementary and Alternative Medicine

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We performed studies on murine models and human volunteers to examine the immunoenhancing effects of the naturally outdoor-cultivated fruit body of Agaricus brasiliensis KA21 (i.e. Agaricus blazei). Antitumor, leukocyte-enhancing, hepatopathy-alleviating and endotoxin shock-alleviating effects were found in mice. In the human study, percentage body fat, percentage visceral fat, blood cholesterol level and blood glucose level were decreased, and natural killer cell activity was increased. Taken together, the results strongly suggest that the A. brasiliensis fruit body is useful as a health-promoting food.

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confidence: 99%

Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers

Liu¹,

Fukuwatari²,

Okumura

et al. 2007

Evidence-Based Complementary and Alternative Medicine

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“…These results suggested that anti‐BG is induced depending on the exposure to fungal BG antigen and the immune responses to BG. We examined the anti‐BG titre in patients with fungal infection or those with a higher risk of fungal infection, such as cancer or dialysis patients . Those patients with weak immune responses to fungi had a lower anti‐BG titre.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic potential of antibody titres against Candida cell wall β-glucan in Kawasaki disease

Ishibashi

Fukazawa

Miura

et al. 2014

Clinical and Experimental Immunology

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SummaryKawasaki disease (KD) is an acute vasculitis syndrome of unknown aetiology in children. The administration of Candida cell wall antigens induced KD-like coronary vasculitis in mice. However, the responses of KD patients to Candida cell wall antigen are unknown. In this study, we examined the response of KD patients to β-glucan (BG), one of the major fungal cell wall antigens, by measuring the anti-BG titre. In KD patients, the anti-C. albicans cell wall BG titre was higher than that in normal children. The anti-BG titre was also higher in KD patients compared to children who served as control subjects. The efficacy of intravenous immunoglobulin (IVIG) therapy in KD is well established. We categorized the KD patients into three groups according to the therapeutic efficacy of intravenous immunoglobulin (IVIG) and compared the anti-BG titre among these groups. Anti-BG titres were similar in the control group and the non-responsive group. In the fully responsive group, the anti-BG titre showed higher values than those in the normal children. This study demonstrated clinically that KD patients have high antibody titres to Candida cell wall BG, and suggested the involvement of Candida cell wall BG in the pathogenesis of KD. The relationship between IVIG therapy and anti-BG titre was also shown. These results provide valuable insights into the therapy and diagnosis of KD.

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“…The anti-BG antibody titer fl uctuated in a patient with a deep mycosis whose serum was β-1,3-glucan-positive, a patient with autoimmune disease (rheumatoid arthritis, antineutrophil cytoplasmic-antibody-associated vasculitis), and a cancer patient. 30 The sera of DBA/1 and DBA/2 mice, as well as bovine species, also contained higher titers of anti-BG antibody. 31,32 In addition, it was recently suggested that anti-BG antibody formed an antigen-antibody complex and participated in the immunopharmacological activity of BG.…”

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confidence: 92%

Effect of Oral Administration of Dried Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae), Fruit Bodies on Anti-β-Glucan Antibody Titers in Humans

et al. 2009

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Agaricus brasiliensis (= Agaricus blazei Murrill sensu Heinem.) is a health food that has received recent attention. β-Glucan is one of the major components of A. brasiliensis. We have reported that an anti-β-glucan antibody was detected in sera from human volunteers. In this study, we examined the reactivity of the anti-BG antibody to A. brasiliensis extracts in human sera and change in the anti-BG antibody titer of healthy volunteers taking A. brasiliensis for 6 months (N = 27, average age = 43 ± 11, male = 13, female = 14). Individual differences in the anti-BG anti body titer existed. We evaluated the rate of change in the titer in each individual. The volunteers in the A. brasiliensis group showed an increase in the anti-BG antibody titer as compared with those in the placebo group. Individual differences existed in the rate of the increase. We fi rst demonstrated a clinical effect of the oral administration of A. brasiliensis on the anti-BG antibody titer. The oral administration of A. brasiliensis induced a β-glucan-specifi c response and there were individual differences in this response. The resulting anti-BG antibody production could be useful as an index of the immune response to β-glucan in humans.

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Anti b-Glucan Antibody in Cancer Patients (Preliminary Report)

Cited by 6 publications

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Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers

Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers

Diagnostic potential of antibody titres against Candida cell wall β-glucan in Kawasaki disease

Effect of Oral Administration of Dried Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae), Fruit Bodies on Anti-β-Glucan Antibody Titers in Humans

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