Anti-bacterial and anti-biofilm properties of green synthesized copper nanoparticles from Cardiospermum halicacabum leaf extract

Parthipan, Punniyakotti; Panneerselvam, Pratheep; Dhandapani, Perumal; Rajasekar, Aruliah; Angaiah, Subramania

doi:10.1007/s00449-020-02357-x

Cited by 81 publications

(20 citation statements)

References 38 publications

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“…Green synthesis methods are simple, easy and pleasant, that's why a lot of scientists use the usual reduction reactions initiated with the use of natural chemical compounds [24][25][26][27][28][29].…”

Section: Resultsmentioning

confidence: 99%

Metal-Humus Acid Nanoparticles - Synthesis, Characterization and Molecular Modeling

Hęclik¹,

Zarzyka²

2021

Pol. J. Environ. Stud.

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In the scientific literature, there is a clear lack of information about deciphering of possible mechanisms of creating metal nanoparticles. The methods described so far are primarily based on the enzymatic reduction (dehydrogenase) relied on the nicotinamidoadenine-dinucleotide (NADH) oxidation [1]. In simultaneous oxidation-reducing reactions, the proper environment was created because of need for reducing metal cations, most often to the form of non-reactive metallic nanoparticles. Similar applications were also shown by reducing sugars [2] or flawonoids [3][4][5][6], as examples of chemical compounds of natural origin. The idea of formation nanoparticles was based on the use of an environment that had properties of reducing metal cations to inert particles having most often nanometric dimensions. With the increase in public awareness

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Section: Resultsmentioning

confidence: 99%

Metal-Humus Acid Nanoparticles - Synthesis, Characterization and Molecular Modeling

Hęclik¹,

Zarzyka²

2021

Pol. J. Environ. Stud.

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“…Unfortunately, we observed that empty nanocarriers lose their activity at least partially against C. albicans as soon as C. acnes is present in biofilms, whatever the age of the studied biofilm. Punniyakotti et al 2020, recently reported the antibiofilm activity of copper nanoparticles studying Pseudomonas and Staphylococcus species [45]. They hypothesized that Cu 2+ ions liberated from the nanoparticles would be engrossed by the bacterial cell surface and cause cell damage, affecting biofilm development.…”

Section: Discussionmentioning

confidence: 99%

Nanovectorized Microalgal Extracts to Fight Candida albicans and Cutibacterium acnes Biofilms: Impact of Dual-Species Conditions

et al. 2020

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Biofilm-related infections are a matter of concern especially because of the poor susceptibility of microorganisms to conventional antimicrobial agents. Innovative approaches are needed. The antibiofilm activity of extracts of cyanobacteria Arthrospira platensis, rich in free fatty acids, as well as of extract-loaded copper alginate-based nanocarriers, were studied on single- and dual-species biofilms of Candida albicans and Cutibacterium acnes. Their ability to inhibit the biofilm formation and to eradicate 24 h old biofilms was investigated. Concentrations of each species were evaluated using flow cytometry. Extracts prevented the growth of C. acnes single-species biofilms (inhibition > 75% at 0.2 mg/mL) but failed to inhibit preformed biofilms. Nanovectorised extracts reduced the growth of single-species C. albicans biofilms (inhibition > 43% at 0.2 mg/mL) while free extracts were weakly or not active. Nanovectorised extracts also inhibited preformed C. albicans biofilms by 55% to 77%, whereas the corresponding free extracts were not active. In conclusion, even if the studied nanocarrier systems displayed promising activity, especially against C. albicans, their efficacy against dual-species biofilms was limited. This study highlighted that working in such polymicrobial conditions can give a more objective view of the relevance of antibiofilm strategies by taking into account interspecies interactions that can offer additional protection to microbes.

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“…Similarly, Punniyakotti et al, prepared copper nanoparticles (Cu NPs) using leaf extracts of Cardiospermum halicacabum and evaluated their antibiofilm efficacy against three clinical strains of S. aureus, E. coli, and P. aeruginosa. They demonstrated that at 100 μg/ml, Cu NPs exhibited maximum antibiofilm activity with 79, 78, and 72% of biofilm inhibition in P. aeruginosa, E. coli, and S. aureus respectively (Punniyakotti et al, 2020). Similarly, Ali and his coworkers biosynthesized terpenoids entrapped copper oxide nanoparticles (ELE-CuONPs) prepared using Eucalyptus globulus (ELE) leaf extract.…”

Section: Copper and Copper Oxide Nanoparticlesmentioning

confidence: 99%

Phyto-fabricated Nanoparticles and Their Anti-biofilm Activity: Progress and Current Status

Das

Ghosh

Nayak

2021

Front. Nanotechnol.

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Biofilm is the self-synthesized, mucus-like extracellular polymeric matrix that acts as a key virulence factor in various pathogenic microorganisms, thereby posing a serious threat to human health. It has been estimated that around 80% of hospital-acquired infections are associated with biofilms which are found to be present on both biotic and abiotic surfaces. Antibiotics, the current mainstream treatment strategy for biofilms are often found to be futile in the eradication of these complex structures, and to date, there is no effective therapeutic strategy established against biofilm infections. In this regard, nanotechnology can provide a potential platform for the alleviation of this problem owing to its unique size-dependent properties. Accordingly, various novel strategies are being developed for the synthesis of different types of nanoparticles. Bio-nanotechnology is a division of nanotechnology which is gaining significant attention due to its ability to synthesize nanoparticles of various compositions and sizes using biotic sources. It utilizes the rich biodiversity of various biological components which are biocompatible for the synthesis of nanoparticles. Additionally, the biogenic nanoparticles are eco-friendly, cost-effective, and relatively less toxic when compared to chemically or physically synthesized alternatives. Biogenic synthesis of nanoparticles is a bottom-top methodology in which the nanoparticles are formed due to the presence of biological components (plant extract and microbial enzymes) which act as stabilizing and reducing agents. These biosynthesized nanoparticles exhibit anti-biofilm activity via various mechanisms such as ROS production, inhibiting quorum sensing, inhibiting EPS production, etc. This review will provide an insight into the application of various biogenic sources for nanoparticle synthesis. Furthermore, we have highlighted the potential of phytosynthesized nanoparticles as a promising antibiofilm agent as well as elucidated their antibacterial and antibiofilm mechanism.

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Anti-bacterial and anti-biofilm properties of green synthesized copper nanoparticles from Cardiospermum halicacabum leaf extract

Cited by 81 publications

References 38 publications

Metal-Humus Acid Nanoparticles - Synthesis, Characterization and Molecular Modeling

Metal-Humus Acid Nanoparticles - Synthesis, Characterization and Molecular Modeling

Nanovectorized Microalgal Extracts to Fight Candida albicans and Cutibacterium acnes Biofilms: Impact of Dual-Species Conditions

Phyto-fabricated Nanoparticles and Their Anti-biofilm Activity: Progress and Current Status

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