Anti-biofilm multi drug-loaded 3D printed hearing aids

Vivero-Lopez, María; Xu, Xiaoyan; Muras, Andrea; Otero, Ana; Concheiro, Ángel; Gaisford, Simon; Basit, Abdul W.; Goyanes, Álvaro

doi:10.1016/j.msec.2020.111606

Cited by 78 publications

(39 citation statements)

References 67 publications

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“…Overall, the DLP printlets received the highest popularity in both boys and girls regardless of different age groups, owing to its bright colour, superior resolution and smooth surface finish. Recently, multiple pharmaceutical applications have been reported utilising these vat photopolymerization 3DP technologies such as SLA and DLP, including drug-loaded oral dosage forms [ 35 , 36 , 37 ] and hydrogels [ 38 , 39 ], polypills [ 40 , 41 ], as well as patient-specific medical devices [ 42 , 43 , 44 ]. However, the lack of generally recognised as safe (GRAS) photocurable materials remains a challenge.…”

Section: Discussionmentioning

confidence: 99%

I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets

et al. 2020

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3D printing (3DP) in the pharmaceutical field is a disruptive technology that allows the preparation of personalised medicines at the point of dispensing. The paediatric population presents a variety of pharmaceutical formulation challenges such as dose flexibility, patient compliance, taste masking and the fear or difficulty to swallow tablets, all factors that could be overcome using the adaptable nature of 3DP. User acceptability studies of 3D printed formulations have been previously carried out in adults; however, feedback from children themselves is essential in establishing the quality target product profile towards the development of age-appropriate medicines. The aim of this study was to investigate the preference of children for different 3D printed tablets (Printlets™) as an important precursor to patient acceptability studies. Four different 3DP technologies; digital light processing (DLP), selective laser sintering (SLS), semi-solid extrusion (SSE) and fused deposition modeling (FDM) were used to prepare placebo printlets with similar physical attributes including size and shape. A single-site, two-part survey was completed with participants aged 4–11 years to determine their preference and opinions based on visual inspection of the printlets. A total of 368 participants completed an individual open questionnaire to visually select the best and worst printlet, and 310 participants completed further non-compulsory open questions to elaborate on their choices. Overall, the DLP printlets were the most visually appealing to the children (61.7%) followed by the SLS printlets (21.2%), and with both the FDM (5.4%) and SSE (11.7%) printlets receiving the lowest scores. However, after being informed that the SSE printlets were chewable, the majority of participants changed their selection and favoured this printlet, despite their original choice, in line with children’s preference towards chewable dosage forms. Participant age and sex displayed no significant differences in printlet selection. Printlet descriptions were grouped into four distinct categories; appearance, perceived taste, texture and familiarity, and were found to be equally important when creating a quality target product profile for paediatric 3D printed formulations. This study is the first to investigate children’s perceptions of printlets, and the findings aim to provide guidance for further development of paediatric-appropriate medicines using different 3DP technologies.

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Section: Discussionmentioning

confidence: 99%

I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets

et al. 2020

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“…After the incubation period at 37 °C, the viability of the bacterial biofilms was evaluated using a modified MTT assay [ 43 ]. Hydrogel pieces were individually placed in sterile tubes containing 3.6 mL of PBS and then sonicated for 15 min to separate and homogenize the biofilms.…”

Section: Methodsmentioning

confidence: 99%

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

et al. 2021

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Contact lenses (CLs) are prone to biofilm formation, which may cause severe ocular infections. Since the use of antibiotics is associated with resistance concerns, here, two alternative strategies were evaluated to endow CLs with antibiofilm features: copolymerization with the antifouling monomer 2-methacryloyloxyethyl phosphorylcholine (MPC) and loading of the antioxidant resveratrol with known antibacterial activity. MPC has, so far, been used to increase water retention on the CL surface (Proclear® 1 day CLs). Both poly(hydroxyethyl methacrylate) (HEMA) and silicone hydrogels were prepared with MPC covering a wide range of concentrations (from 0 to 101 mM). All hydrogels showed physical properties adequate for CLs and successfully passed the hen's egg-chorioallantoic membrane (HET-CAM) test. Silicone hydrogels had stronger affinity for resveratrol, with higher loading and a slower release rate. Ex vivo cornea and sclera permeability tests revealed that resveratrol released from the hydrogels readily accumulated in both tissues but did not cross through. The antibiofilm tests against Pseudomonas aeruginosa and Staphylococcus aureus evidenced that, in general, resveratrol decreased biofilm formation, which correlated with its concentration-dependent antibacterial capability. Preferential adsorption of lysozyme, compared to albumin, might also contribute to the antimicrobial activity. In addition, importantly, the loading of resveratrol in the hydrogels preserved the antioxidant activity, even against photodegradation. Overall, the designed hydrogels can host therapeutically relevant amounts of resveratrol to be sustainedly released on the eye, providing antibiofilm and antioxidant performance.

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“…However, a large amount of filler (up to 70%) limits the depth of light penetration Photoinduced radical polymerization of various monomers has been gaining more and more interest in various industries in recent decades [6,32]. Many of the developed photoinitiating systems meet the requirements for specific applications in the technology of protective coatings [33][34][35], graphics industry [36], microelectronics [37], optical disc production [38], holography [39][40][41], stereolithography [42][43][44] and medicine [45][46][47][48][49][50][51]. Photopolymerization has also become an integral part of dental practice [52].…”

Section: Of 22mentioning

confidence: 99%

Acenaphthoquinoxaline Derivatives as Dental Photoinitiators of Acrylates Polymerization

Pyszka

Jędrzejewska

2021

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A series of dyes based on the acenaphthoquinoxaline skeleton was synthesized. Their structure was modified by introducing electron-withdrawing and electron-donating groups, increasing the number of conjugated double bonds and the number and position of nitrogen atoms, as well as the arrangement of aromatic rings (linear or angular). The dyes were investigated as a component in the photoinitiating systems of radical polymerization for a potential application in dentistry. They acted as the primary absorber of visible light and the acceptor of an electron, which was generated from a second component being an electron donor. Thus, the radicals were generated by the photoinduced intermolecular electron transfer (PET) process. Electron donors used differed in the type of heteroatom, i.e., O, S and N and the number and position of methoxy substituents. To test the ability to initiate the polymerization reaction by photoinduced hydrogen atom transfer, we used 2-mercaptobenzoxazole as a co-initiator. The effectiveness of the photoinitiating systems clearly depends on both the modified acenaphthoquinocaline structure and the type of co-initiator. The lower amount of heat released during the chain reaction and the polymerization rate comparable to this achieved for the photoinitiator traditionally used in dentistry (camphorquinone) indicates that the studied dyes may be valuable in this field.

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Anti-biofilm multi drug-loaded 3D printed hearing aids

Cited by 78 publications

References 67 publications

I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets

I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

Acenaphthoquinoxaline Derivatives as Dental Photoinitiators of Acrylates Polymerization

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