Anti-bone resorption activity of deer antler aqua-acupunture, the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe (Nokyong) in adjuvant-induced arthritic rats

Herbal formulation, Yukmi-jihang-tang-Jahage, regulates bone resorption by inhibition of phosphorylation mediated by tyrosine kinase Src and cyclooxygenase expression

“…It was demonstrated that IL-1␤ stimulate PGE2 production in human calvarial osteoblasts (Kim et al, 2005b). And the involvement of COX-1, COX-2 and tyrosine kinases, on the synergy between EGF and IL-1␤ on PGE2 production were shown in human gingival fibroblasts (Yucel-Lindberg et al, 1999;Park et al, 2004b).…”

Effect of antler extract on corticosteroid-induced avascular necrosis of the femoral head in rats

“…Kim et al reported that the inter-trabecular connections were well maintained and bone loss was absent upon administration of osteoporosis-induced rats with antler extract (Kim et al, 2003). Recent studies also found that antler extract inhibited osteoclast differentiation and bone reabsorption (Kim et al, 2005;Li et al, 2007). In addition, antler has therapeutic effects such as lowering the cholesterol levels, improving circulation, promoting the antibody production and hematopoiesis of bone marrow (Soshnianina, 1974;Zhao et al, 1992;Sleivert et al, 2003;Yang et al, 2004b).…”

Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption

“…Kim et al reported that the inter-trabecular connections were well maintained and bone loss was absent upon administration of osteoporosis-induced rats with antler extract (Kim et al, 2003). In addition, Kim et al reported that deer antler aqua-acupunture (DAA) had anti-bone resorption activity in adjuvant-induced arthritic rats (Kim et al, 2005). These results suggest that deer antler may affect bone metabolism including bone resorption.…”