Anti-C1q antibodies are associated with systemic lupus erythematosus disease activity and lupus nephritis in northeast of China

Zhang, Caiqin; Ren, Lei; Gao, Fei; Mu, Fengyun; You, Yanqiu; Liu, Yanhong

doi:10.1007/s10067-011-1698-1

Cited by 18 publications

(14 citation statements)

References 19 publications

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“…Braun et al found a prevalence of 61.7% in biopsy proven lupus nephritis cases 29 and Wener et al, 48% 21 . The strongest clinical association we observed for anti-C1q was with proteinuria, consistent with published data 12, 14, 16, 27, 34 . Our study was undertaken in patients with SLE from a multicenter, multiethnic patient population and an equal number of patients with other rheumatic diseases (controls), in which complete clinical, serologic and candidate criteria variables were assessed for the purpose of deriving SLE classification rules.…”

Section: Discussionsupporting

confidence: 92%

Anti-C1q antibodies in systemic lupus erythematosus

Orbai

Truedsson

Sturfelt

et al. 2014

Lupus

103

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Objective Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs. rheumatic disease controls) and the association with SLE manifestations in an international multi-center study. Methods Information and blood samples were obtained in a cross-sectional study from patients with SLE (n=308) and other rheumatologic diseases (n=389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA. Results Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR=2.7, 95% CI: 1.8-4, p<0.001). Anti-C1q was associated with proteinuria (OR=3.0, 95% CI: 1.7-5.1, p<0.001), red cell casts (OR=2.6, 95% CI: 1.2-5.4, p=0.015), anti-dsDNA (OR=3.4, 95% CI: 1.9-6.1, p<0.001) and anti-Smith (OR=2.8, 95% CI: 1.5-5.0, p=0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR=2.3, 95% CI: 1.3-4.2, p<0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR=14.9, 95% CI: 5.8-38.4, p<0.01). Conclusions Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis.

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Section: Discussionsupporting

confidence: 92%

Anti-C1q antibodies in systemic lupus erythematosus

Orbai

Truedsson

Sturfelt

et al. 2014

Lupus

103

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“…[172127] Our study showed a slightly higher incidence of anti-C1q antibodies (60%) in LN patients compared to non-LN patients (53.3%). This finding was similar to the studies reported by Zang et al .…”

Section: Discussionmentioning

confidence: 71%

“…and Katsumata et al . [2122] It was suggested that the circulating anti-C1q antibodies may bind to the C1q deposits in the kidneys of LN patients and this consumption of serum anti-C1q antibodies by binding to C1q-containing immune complexes could be responsible for the lack of significant difference among LN and non-LN patients. [24] It was also reported that although a high prevalence of anti-C1q antibodies correlated with proliferative LN, the predictive value of 27-68%, in the presence of anti-C1q antibodies, among LN patients was too low to reliably identify them as LN, and that up to 46% renal flares occurred in patients who did not develop anti-C1q antibodies.…”

Section: Discussionmentioning

confidence: 99%

Anti-C1q antibodies and their association with complement components in Indian systemic lupus erythematosus patients

Pradhan¹,

Rajadhyaksha²,

Mahant³

et al. 2012

Indian J Nephrol

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Systemic lupus erythematosus (SLE) is a prototype autoimmune disease, characterized by immune complex formation and systemic inflammation. Complement components such as C1q and mannose-binding lectin (MBL) play an important role in the clearance of immune complexes. Anti-C1q antibodies are associated with lupus nephritis and reduced levels of the complement components. The objective of this study was to detect anti-C1q antibodies in SLE patients and to evaluate their association with the complement components. Sixty SLE patients were included, of whom 75% had lupus nephritis (LN) and 25% were without renal manifestations (non-LN). The disease activity was assessed at the time of evaluation by the systemic lupus erythematosus disease activity index (SLEDAI). Anti-C1q antibodies, circulating immune complexes, and serum MBL levels were detected by enzyme-linked immunosorbent assay. The anti-C1q antibody prevalence was 58.3%. The LN patients showed 60% anti-C1q positivity with a higher percentage in membranoproliferative glomerulonephritis patients (51.9%). Anti-dsDNA positivity was slightly higher among the anti-C1q positives than in the anti-C1q negatives (65.7% vs. 60%). A higher percentage of reduced C3 and C4 levels was noted among the anti-C1q positives. The LN patients showed a higher percentage of low MBL levels among anti-C1q negatives than in the anti-C1q positives (61.1% vs. 55.6%). Non-LN patients showed a higher percentage of low MBL levels among anti-C1q positives than among anti-C1q negatives (87.5% vs. 57.1%). Anti-C1q antibodies were found in both LN and non-LN patients, but there was no correlation with the clinical severity of the disease.

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“…Anti-C1q antibodies are highly prevalent in prototypical autoimmune disease, systemic lupus erythematosus (SLE), exhibiting strong correlation with lupus nephritis (Hu et al, 2013;Mahler et al, 2013;Trouw et al, 2004;Zhang et al, 2011). These antibodies are also detected in hypocomplementemic urticarial vasculitis, rheumatoid vasculitis, IgA nephropathy, anti-glomerular basement membrane (anti-GBM) nephropathy, and HIV infection (Mahler et al, 2013).…”

Section: Introductionmentioning

confidence: 97%

Anti-C1q in chronic hepatitis C Virus genotype IV infection: association with autoimmune rheumatologic manifestations

Fadda

Bassyouni

Hamdy

et al. 2014

Immunological Investigations

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A growing body of evidence suggests that anti-complement-1q (anti-C1q) antibodies are elevated in a variety of autoimmune disease. Therefore, we investigated their prevalence and clinical significance in plasma of patients with hepatitis C virus (HCV) genotype IV in the presence and absence of autoimmune extra hepatic manifestations in comparison to normal healthy individuals. Plasma Anti-C1q Abs levels were assessed by an Enzyme Linked Immunosorbant Assay in 91 chronic HCV-infected patients (51 with and 40 without autoimmune rheumatic manifestations) and 40 healthy volunteers matched for age and gender. Epidemiological, clinical, immunochemical and virological data were prospectively collected. Positive Anti-C1q antibodies were more frequent among HCV patients with extra-hepatic autoimmune involvement, than those without and healthy control subjects. No significant correlations were found between Anti-C1q levels with either the liver activity or the fibrosis scores. In HCV-patients with autoimmune involvements, plasma Anti-C1q levels were significantly higher in patients with positive cryoglobulin, and in those with lymphoma than in those without. These results were confirmed by multivariate analysis. Further large scale longitudinal studies are required to assess and clarify the significance and the pathogenic role of anti-C1q antibodies among HCV infected patients with positive cryoglobulinaemia and lymphoma.

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Anti-C1q antibodies are associated with systemic lupus erythematosus disease activity and lupus nephritis in northeast of China

Cited by 18 publications

References 19 publications

Anti-C1q antibodies in systemic lupus erythematosus

Anti-C1q antibodies in systemic lupus erythematosus

Anti-C1q antibodies and their association with complement components in Indian systemic lupus erythematosus patients

Anti-C1q in chronic hepatitis C Virus genotype IV infection: association with autoimmune rheumatologic manifestations

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