Anti-cancer activity and mechanism of flurbiprofen organoselenium compound RY-1-92 in non-small cell lung cancer

Cui, Bo; Cheng, Xianda; Zhang, Xin; Chen, Lili; Pang, Wenqian; Liu, Yue; Yang, Zhe; Li, Hui; He, Xianran; Li, Xiaolong; Bi, Xiuli

doi:10.1039/d4md00058g

RSC Med. Chem.

2024

DOI: 10.1039/d4md00058g

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Anti-cancer activity and mechanism of flurbiprofen organoselenium compound RY-1-92 in non-small cell lung cancer

Bo Cui,

Xianda Cheng,

Xin Zhang

et al.

Abstract: Lung cancer is one of the malignancies with the highest incidence and mortality rates worldwide, and non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer types....

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Cited by 2 publications

References 31 publications

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Research progress on selenium system in cancer therapy: Focus on interface modifications and improvement of interactions

He,

Huang,

Xie

et al. 2025

Surfaces and Interfaces

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Research progress on selenium system in cancer therapy: Focus on interface modifications and improvement of interactions

He,

Huang,

Xie

et al. 2025

Surfaces and Interfaces

View full text Add to dashboard Cite

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer

Coutinho,

Femino,

Gonzalez

et al. 2024

IJMS

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Nitric oxide (NO) and reactive nitrogen species (RNS) exert profound biological impacts dictated by their chemistry. Understanding their spatial distribution is essential for deciphering their roles in diverse biological processes. This review establishes a framework for the chemical biology of NO and RNS, exploring their dynamic reactions within the context of cancer. Concentration-dependent signaling reveals distinctive processes in cancer, with three levels of NO influencing oncogenic properties. In this context, NO plays a crucial role in cancer cell proliferation, metastasis, chemotherapy resistance, and immune suppression. Increased NOS2 expression correlates with poor survival across different tumors, including breast cancer. Additionally, NOS2 can crosstalk with the proinflammatory enzyme cyclooxygenase-2 (COX-2) to promote cancer progression. NOS2 and COX-2 co-expression establishes a positive feed-forward loop, driving immunosuppression and metastasis in estrogen receptor-negative (ER-) breast cancer. Spatial evaluation of NOS2 and COX-2 reveals orthogonal expression, suggesting the unique roles of these niches in the tumor microenvironment (TME). NOS2 and COX2 niche formation requires IFN-γ and cytokine-releasing cells. These niches contribute to poor clinical outcomes, emphasizing their role in cancer progression. Strategies to target these markers include direct inhibition, involving pan-inhibitors and selective inhibitors, as well as indirect approaches targeting their induction or downstream effectors. Compounds from cruciferous vegetables are potential candidates for NOS2 and COX-2 inhibition offering therapeutic applications. Thus, understanding the chemical biology of NO and RNS, their spatial distribution, and their implications in cancer progression provides valuable insights for developing targeted therapies and preventive strategies.

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Anti-cancer activity and mechanism of flurbiprofen organoselenium compound RY-1-92 in non-small cell lung cancer

Abstract: Lung cancer is one of the malignancies with the highest incidence and mortality rates worldwide, and non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer types....

Cited by 2 publications

References 31 publications

Research progress on selenium system in cancer therapy: Focus on interface modifications and improvement of interactions

Research progress on selenium system in cancer therapy: Focus on interface modifications and improvement of interactions

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer

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