Anti-cancer activity of di- and tri-organotin(IV) compounds with D-(+)-Galacturonic acid on human tumor cells

Attanzio, Alessandro; Ippolito, Maristella; Girasolo, Maria Assunta; Saiano, Filippo; Rotondo, Archimede; Rubino, Simona; Mondello, Luigi; Capobianco, Massimo L.; Sabatino, Piera; Tesoriere, Luisa; Casella, Girolamo

doi:10.1016/j.jinorgbio.2018.04.006

Cited by 33 publications

(23 citation statements)

References 50 publications

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“…At T 72 , 37 VOCs were identified, whereby five compounds were significantly decreased and 32 VOCs significantly increased (p < 0.05). [35,36] This could potentially explain the marked reduction in proliferation of normal cells compared to co-cultures with the cancerous cells, and might be related to a volatile signal. Interestingly, five VOCs were commonly found at T 24 , T 48 , and T 72 in all groups.…”

Section: Effect Of Interspecific Vocs In Cell-cell Interactionsmentioning

confidence: 99%

Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation

2019

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Cell–cell cross talk is of great importance in cancer research due to its major role in proliferation, differentiation, migration, and influence on the apoptotic pathway. Different cell–cell communication mechanisms have come mainly from proteomic and genomic approaches. In this paper, a new route is reported for cross talk between cancer cells that occurs, even when they are far away from each other. Single‐cell and culture analysis shows that upregulation of cancer cells emits hundreds of volatile organic compounds (VOCs) into their headspace. Part of the VOCs remains without any change, disregarding the biological environment around it. The other part of the VOCs is exchanged between monocultures of the cells as well as between co‐cultures of the cells with no physical contact between them, leading to different changes in growth than when left on their own. The chemical nature and composition of these VOCs have been determined and are discussed herein. Cell‐to‐cell cross talk has the advantage of being suitable for transfer/diffusion over relatively long distances. It would thus be expected to serve as a shuttling pad toward the development of advanced approaches that could enable very early detection of cancer and/or monitoring of metastasis and related cancer therapy.

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Section: Effect Of Interspecific Vocs In Cell-cell Interactionsmentioning

confidence: 99%

Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation

2019

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“…A tri ‐n‐ butyltin complex with a d ‐(+)‐galacturonic acid ligand ( 55 ) was cytotoxic to HCT‐116 and MCF‐7 cells in the nM range. [ 53 ] However, the complex is unable to cross the cell membrane. Thus, the authors concluded that the cytotoxicity of 55 could be exerted via cation–cell membrane interactions.…”

Section: In Vitro Cytotoxicity In Cancer Cellsmentioning

confidence: 99%

Triorganotin complexes in cancer chemotherapy: Mechanistic insights and future perspectives

Anasamy

Chee

Wong

et al. 2020

Applied Organom Chemis

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Current anticancer drug discovery and development efforts are aimed at identifying new complexes that can potently and selectively target DNA and modulate the functions of target proteins. Tin complexes, categorized as monoorganotin (RSnL3), diorganotin (R2SnL2), triorganotin (R3SnL), or tetraorganotin (R4SnL), are one of the most studied complexes in the metal‐based anticancer drug discovery and development field. Among these, diorganotins and triorganotins are widely reported to possess promising anticancer properties, with triorganotins offering several potential advantages over diorganotins, such as a higher total surface area causing higher lipophilicity and hence higher cytotoxicity in cancer cells. However, information on triorganotins' direct therapeutic targets, an in‐depth understanding of their mechanism of action, and useful therapeutic strategies are still lacking. In this review, we discuss the results from in vitro and in vivo mechanistic studies of triorganotin complexes as reported in recent years (2007–2019) and elaborate on the underlying mechanisms that could aid in the identification of triorganotin complex molecular targets. We conclude by identifying present obstacles faced by triorganotin complexes that avert their translation to the clinical phase and current strategies employed to overcome the aforementioned obstacles, and we offer considerations for their future development. These findings are anticipated to stimulate further developments of novel and innovative triorganotin complexes as anticancer drug candidates.

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“…Cytotoxic activity against MCF-7 cells of complex(1) is associated to apoptosis [9,29]. To evaluate whether the loading procedure into the silica carriers and subsequent release of the drug modified its biological activity, flow cytometry analysis for Annexin V binding and PI uptake of MCF-7 cells after treatment with complex(1) loaded into mesoporous silica nanoparticles, was carried out (Fig.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Loading and release of the complex [Pt(DTBTA)(DMSO)Cl]Cl·CHCl3 with the 2,2′-dithiobis(benzothiazole) ligand into mesoporous silica and studies of antiproliferative activity on MCF-7 cells

et al. 2018

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Synthetic delivery systems have great potential for overcoming problems associated with systemic toxicity that accompanies chemotherapy with the use of cisplatin and family of platinum anticancer drugs. Mesoporous silicates have been studied in context of drug delivery and drug targeting. In this paper we report the studies of loading and release of a platinum complex, [Pt(DTBTA)(DMSO)Cl]Cl•CHCl 3 (1) where DTBTA = 2,2 0-dithiobis(benzothiazole), that was recently synthesized and structurally characterized. Evaluation in vitro of antitumor activity against a human breast cancer cell line (MCF-7) showed a very potent activity of complex(1). Therefore, we thought to incorporate this compound into MCM41 mesoporous silica and into analogous support functionalized with amino groups (MCM41-NH 2). The complex(1) encapsulation efficiency % (EE%) in MCM41 and in MCM41-NH 2 , respectively, was evaluated by using UV-Vis spectroscopy. The porosimetry and IR spectra confirmed that the drug was within the pores in MCM-41 and that the complex(1) binds MCM41-NH 2 with the aminopropyl functional groups of the mesoporous channels, respectively. The study of release was performed by using UV-Vis spectroscopy at 37 ± 1°C in 0.1 M phosphate buffer solution (PBS) having pH 7.4 to simulate the physiological pH of blood. In order to investigate the efficacy of MCM-41/complex(1) and MCM41-NH 2 /complex(1) conjugates, we have measured their ability to kill cancer cells of MCF-7 (human breast cancer). MTT test and cytofluorimetric assay of exposure of phosphatidylserine to the outer membrane were carried out to measure cytotoxicity and apoptosis induced by MCM41/complex(1) and MCM41-NH 2 /complex(1). The investigated systems were very efficient for pharmaceutical controlled release and a promising agent for combination therapies.

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Anti-cancer activity of di- and tri-organotin(IV) compounds with D-(+)-Galacturonic acid on human tumor cells

Cited by 33 publications

References 50 publications

Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation

Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation

Triorganotin complexes in cancer chemotherapy: Mechanistic insights and future perspectives

Loading and release of the complex [Pt(DTBTA)(DMSO)Cl]Cl·CHCl3 with the 2,2′-dithiobis(benzothiazole) ligand into mesoporous silica and studies of antiproliferative activity on MCF-7 cells

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