Anti-cancer activity of human gastrointestinal bacteria

Quazi, Sameer

doi:10.1007/s12032-022-01771-3

Cited by 4 publications

(6 citation statements)

References 195 publications

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“…The Role of Artificial Intelligence (AI) in Precision Medicine is exceptionally important [51–55]. The healthcare industry already experiences a rapid shift to Precision Medicine requests from physicians and patients and other stakeholders.…”

Section: Resultsmentioning

confidence: 99%

“…In the following study fundamentals of AI and Big Data are presented in the context of potential applications to data analytics in public health and the medical sciences. Humans will eventually gain unprecedented insights into the diagnosis and possible treatment of diseases as the various AI learning algorithms interact with training data [53].…”

Section: Resultsmentioning

confidence: 99%

“…At the same time the benefits of Precision/Personalized Medicine and the major obstacles for all stakeholders involved are summarized as well as specific solutions are provided. Knowledge and perception of Medical and Pharmacy students towards Pharmacogenomics and Genetics is also presented [6, 8–10, 22, 27–29, 33, 34, 45, 51, 53–55, 59, 67, 74–77, 81–83, 85–107, 112, 113, 121].…”

Section: Resultsmentioning

confidence: 99%

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Advancing precision medicine in medical education: Integrated, precise and data‐driven smart solutions

Papadopoulou

Lytras

2023

Applied Research

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Advances in “Precision Medicine” initiative, also known as “Personalized Medicine” is an emerging approach for disease treatment and prevention that has already led to innovative discoveries and has created “smart” applications and solutions tailored to a person's or a group of individuals' genetic profile, lifestyle, and environment interaction. Already many physicians as part of patient care routinely prescribe various molecular/genetic and other tests enabling them to select personalized treatments that improve the chances of survival and reduce exposure to adverse effects. This initiative should provide to medical and healthcare professionals with adequate resources and readily available solutions so that the target to specific treatments and care of the illnesses is achieved while at the same time protecting the privacy and safety of the individual is secured as well as the Electronic Health Records (EHRs) and whatever additional data is necessary within the context of Precision Medicine. This study, through a literature review mostly, and some case study analysis, examine whether personalized medicine is delivered to the patient in an “accurate” and “precise” way, as expected. This requires that Health and Human Services and other stakeholders and agencies collaborate to solicit the right input from patients while at the same time can identify and address any educational, practical, legal, and technical issues and providing smart solutions. The lack of proper medical education and advanced infrastructure are still major barriers to the adoption of Precision Medicine, therefore, the role of medical training in Precision Medicine is also examined and analyzed. Specific examples are discussed in an integrated, precise, and data‐driven manner to provide “smart” solutions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Advancing precision medicine in medical education: Integrated, precise and data‐driven smart solutions

Papadopoulou

Lytras

2023

Applied Research

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“…Gastrointestinal cancer is one of the most lethal human cancers, which is a significant unresolved concern in the World (Quazi 2022). The gut is the most intricate part of the human body, comprising a wide range of microbiomes.…”

Section: Effect Of the Compounds Of Eu In On The Prevention Of Gastro...mentioning

confidence: 99%

Biochemical and microbial meta-profiling reveal the anti-cancer efficacy of Eu—an endemic traditional brew of the Toto tribe from India

Bhattacharjee,

Sarkar,

Sarkar

et al. 2024

Bull Natl Res Cent

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Background Eu is a lesser-known and traditional millet-based fermented brew of the Toto tribe from West Bengal, India. The starter culture used in this brew consists of diverse microflora. Identifying those microbes will not only help us gain a deeper understanding of the brew, but also quantify the impacts of this brew on the human system after consumption. Due to the progress in Illumina sequencing technology, the meta-profiling of 16S rRNA has emerged as a valuable resource for exploring the microbiome of any sample. We have utilised this tool (V3–V4 region) to study the microbiome population of Eu. Results The microbial diversity present in the brew was mainly constituted of probiotic and fermenting bacteria. The nutrient profiling of Eu estimated the amount of protein, carbohydrate, free amino acid, and free fatty acid. The nutritional substance present in the brew probably supports the growth of the probiotic microflora. Reverse ecology-based network analysis revealed considerable complementary interaction between humans and the microflora present in the Eu. GC–MS outlining enlisted thirteen potent compounds from Eu, and a comprehensive network pharmacological study on those compounds revealed the anti-cancerous properties of Eu, especially against gastrointestinal malignancy, by reducing the proliferation of malignant cells and forming pro-inflammatory cytokines. Conclusions The current study focuses on the meta-profiling and nutritional characteristics of Eu, which highlight the beverage’s potential as a probiotic health drink. Reverse ecology analysis demonstrated that the probiotic microflora competes strongly against pathogenic bacteria. Additionally, in silico network pharmacological research identified the drink as a potentially health-promoting and anti-cancer beverage.

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“…In consideration of the fact that, as highlighted, the metabolic disorders that correlate with the incidence and progression of tumors are often associated with conditions of dysbiosis of the microbiota, it is understandable that an effective preventive or therapeutic treatment cannot be separated from the control of this variable. We have seen how numerous and important scenarios induced by alterations to the bacteria of the gut microbiota are able to interfere with various pathophysiological processes that lead to the formation and progression of numerous pathologies, including tumors [ 28 , 29 , 30 , 31 , 32 ], and consequently, it is no longer acceptable to disregard any possible ways to improve our ability to modulate this scenario as well [ 33 ].…”

Section: Possibility Of Intervention Treatment Of Metabolic Disorders...mentioning

confidence: 99%

Gut Microbiota, Metabolic Disorders and Breast Cancer: Could Berberine Turn Out to Be a Transversal Nutraceutical Tool? A Narrative Analysis

Cazzaniga

Zonzini

Pierro

et al. 2022

IJMS

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Metabolic disorders, mainly characterized as the marked alteration of the lipid and carbohydrate profile, in addition to the clinical presence of the direct consequences of these alterations, are pathological conditions that have considerably increased in prevalence in recent years. They are directly linked to the onset of various pathologies, including cancer, particularly breast cancer, and are hormone-responsive. Alongside the known conditions responsible for this scenario, such as nutrition and lifestyle in general, the importance of both the colonic microbiota and the various organs and systems is becoming increasingly evident. In fact, it is now evident that microbial dysbiosis plays a fundamental role in the onset of these metabolic disorders, and therefore how these conditions are indirectly responsible for the onset and progression of neoplasms. Indirect mechanisms such as an altered Firmicutes/Bacteroidetes ratio; the formation of metabolites such as short-chain fatty acids (SCFAs), in particular, butyrate, which is capable of acting as a tumor suppressor; and the glucuronidase activity of estroboloma (bacteria responsible for estrogen metabolism) are just some of the most important mechanisms that contribute to the history of breast cancer. It is therefore understandable that in clinical terms, it is essential to associate the modulation of metabolic disorders and the microbial conditions that contribute to generating them with common therapies, preferably using compounds and solutions that are effective and acceptable for the patient without side effects. Nutraceuticals such as berberine (active both in metabolic scenarios and in the microbiota) and interventions modulating the microbial structure such as the use of probiotics and prebiotics seem to be ideal solutions for these preventive and no-longer-ignorable strategies in the light of numerous data now present in the literature.

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Anti-cancer activity of human gastrointestinal bacteria

Cited by 4 publications

References 195 publications

Advancing precision medicine in medical education: Integrated, precise and data‐driven smart solutions

Advancing precision medicine in medical education: Integrated, precise and data‐driven smart solutions

Biochemical and microbial meta-profiling reveal the anti-cancer efficacy of Eu—an endemic traditional brew of the Toto tribe from India

Gut Microbiota, Metabolic Disorders and Breast Cancer: Could Berberine Turn Out to Be a Transversal Nutraceutical Tool? A Narrative Analysis

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