Anti-Cancer and Anti-Inflammatory Potential of Furanocoumarins from Ammi majus L.

Abstract

: Secondary metabolites have potential benefits to human being. They are used in the food, agricultural and pharmaceutical industries. The secondary metabolite of furanocoumarins from different plant sources is essential in various skin-related ailments. Biologically, these chemicals are isolated from different plants in the Apiaceae, Fabaceae, Rutaceae and Moraceae families. Ammi majus L. is one of the most common plants in the family of Apiaceae with a large quantity of derivatives. The furanocoumarin derivatives defend the plant by fighting external enemies by Systemic Acquired Resistance (SAR). Via suppressing or retarding microbial growth in infected parts, these derivatives, along with SAR, help to alleviate inflammation in the human body. Latest evidence of these compounds has been established in the treatment of cancer, but the mechanism that needs to be elaborated is not yet understood. Recent studies have shown that furanocoumarin derivatives bind to DNA base pairs and block DNA replication. This may be a potential pathway that helps to regulate the growth of cancerous cells. This article reflects on the pharmaceutical data of furanocoumarins and their different mechanisms in these cases.

Mechanisms of anti-ulcer actions of Prangos pabularia (L.) in ethanol-induced gastric ulcer in rats

“…REPP supplementation caused positive modulation of inflammatory cytokines shown by lower TNF-α, IL-6, and higher IL-10 cytokine levels compared to ulcer controls. Consistently, numerous researchers have shown the anti-inflammatory potentials of furocoumarin (a major constituent of REPP), which were detected in other plant species ( Agour et al, 2022 , Balkrishna et al, 2022 , Huang et al, 2022a ).…”

Quantitative Analysis of Isopimpinellin from Ammi majus L. Fruits and Evaluation of Its Biological Effect on Selected Human Tumor Cells

“…Various parts of this plant (mainly the fruits, but also the leaves and whole aerial parts) have been used in the treatment of various dermatological diseases, especially vitiligo, and in traditional medicine (mainly fruits) as an emmenagogic, diuretic, and blood purifier agent in the treatment of leprosy and urinary and digestive system disorders [ 14 ]. Several review articles have recently summarized the various pharmacological effects of this important natural medicine [ 14 , 15 , 16 , 17 ]. This plant material serves as an excellent source of furanocoumarins, especially bergapten (5 MOP), xanthotoxin (8 MOP), and isopimpinellin (IsoP) [ 14 , 15 ], whose content was qualitatively and quantitatively evaluated in several studies.…”