Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell

Choi, Bomi; Joo, Jong Cheon; Lee, Yeon Kyu; Jang, Ik Soon; Park, Soo Jung; Park, Yoon Jung

doi:10.1186/s12906-017-1776-2

Cited by 29 publications

(20 citation statements)

References 34 publications

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“…This in turn increases the severity of toxic side-effects. These side-effects are primarily due to the dose-limiting effects of the drug on neurotoxicity and ototoxicity, although other common side-effects include severe nausea, vomiting, gastrotoxicity and myelosuppression ( 28 – 31 ).…”

Section: Introductionmentioning

confidence: 99%

Suppression of YAP by DDP disrupts colon tumor progression

Guo

et al. 2018

Oncol Rep

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Colon cancer is a commonly diagnosed cancer that often has a poor prognosis. Combined with the development of drug resistance to cancer treatment agents the treatment efficacy of colon cancer can be limited. Activation of the oncogene YAP has been shown to be related to colon cancer progression and is associated with poor prognosis, drug resistance and metastasis, even under treatment. Cisplatin (DDP) is a commonly used drug that can control carcinoma progression, although its mechanisms are poorly understood. In the present study, we examined whether DDP specifically suppressed YAP in order to inhibit colon carcinoma progression. Our data revealed that Mst/Yap signaling was unusually activated in colon cancers, promoting cell proliferation and invasion. DDP treatment decreased the expression of YAP at both the transcriptional and post-translational levels, leading to cell cycle arrest, apoptosis and senescence in cancer cells, in addition to decreasing epithelial-to-mesenchymal transition, cell motility and in vitro cell invasion and migration. Ultimately, DDP increased the expression of E-cadherin and decreased the expression of vimentin. The present study also revealed that post-translational regulation of YAP phosphorylation controlled the subcellular distribution between the nucleus and the cytoplasm. In conclusion, the findings of the present study revealed that DDP was a suitable therapeutic candidate for colon cancer that specifically targets the Mst/Yap signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Suppression of YAP by DDP disrupts colon tumor progression

Guo

et al. 2018

Oncol Rep

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“…SB, one kind of traditional Chines herbal, has been increasingly used in the last decades and become well known for its significant role in preventing and treating inflammatory disease and cancer [ 40 , 41 ]. In the present study, the decline in FEV0.1/FVC (%), PEF, and MMEF and the rise in FRC in response to CS were normalized by SB, supporting the ability of SB on alleviation of airway obstruction and pulmonary function.…”

Section: Discussionmentioning

confidence: 99%

Scutellaria baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF‐κB Pathway in Cigarette Smoke Mediated‐COPD Rats Model

Lin

Cui

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Background. Scutellaria baicalensis (SB) is commonly used in traditional Chinese medicine for chronic inflammatory diseases. This study aims to investigate the effects of the early intervention with SB on airway remodeling in a well-established rat model of COPD induced by cigarette smoking. Methods. COPD model in Sprague Dawley (SD) rats were established by exposing them to smoke for 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Meanwhile, rats were randomly divided into normal control group, model group, Budesonide (BUD) group, and the SB (low, middle, and high) dose groups with 8 rats in each group and 3 stages (12 weeks, 24 weeks, and 36 weeks). After treatment, the pulmonary function was evaluated by BUXCO system and the morphology changes of the lungs were observed with HE and Masson staining. The serum IL-6, IL-8, and IL-10 and TNF-α, TGF-beta (TGF-β1), MMP-2, MMP-9, and TIMP-1 levels in BALF were detected by ELISA-kit assay. The protein expression levels of AKT and NF-κB (p65) were determined by western blot (WB). Results. The oral of SB significantly improved pulmonary function (PF) and ameliorated the pathological damage and attenuated inflammatory cytokines infiltration into the lungs. Meanwhile, the levels of TGF-β, MMP-2, MMP-9, and TIMP-1 were partially significantly decreased. The levels of PI3K/AKT/NF-κB pathway were also markedly suppressed by SB. Conclusions. SB could significantly improve the condition of airway remodeling by inhibiting airway inflammation and partially quenching TGF-β and MMPs via PI3K/AKT/NF-κB pathway.

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“…As MOD concentrations increased, cytotoxicity of cisplatin to A2780 and A2789cis cells became more similar. Such synergistic effects of combining compounds with cisplatin have also been reported in treated human non-small cell lung cancer NCI-H23 cells as well as ovarian cancer A2780cis cells [22,23].…”

Section: Discussionmentioning

confidence: 77%

Promotion of Cell Death in Cisplatin-Resistant Ovarian Cancer Cells through KDM1B-DCLRE1B Modulation

Lee

Lim

Yoon

et al. 2019

IJMS

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Ovarian cancer is the gynecological malignancy with the poorest prognosis, in part due to its high incidence of recurrence. Platinum agents are widely used as a first-line treatment against ovarian cancer. Recurrent tumors, however, frequently demonstrate acquired chemo-resistance to platinum agent toxicity. To improve chemo-sensitivity, combination chemotherapy regimens have been investigated. This study examined anti-tumor effects and molecular mechanisms of cytotoxicity of Oldenlandia diffusa (OD) extracts on ovarian cancer cells, in particular, cells resistant to cisplatin. Six ovarian cancer cells including A2780 and cisplatin-resistant A2780 (A2780cis) as representative cell models were used. OD was extracted with water (WOD) or 50% methanol (MOD). MOD significantly induced cell death in both cisplatin-sensitive cells and cisplatin-resistant cells. The combination treatment of MOD with cisplatin reduced viability in A2780cis cells more effectively than treatment with cisplatin alone. MOD in A2780cis cells resulted in downregulation of the epigenetic modulator KDM1B and the DNA repair gene DCLRE1B. Transcriptional suppression of KDM1B and DCLRE1B induced cisplatin sensitivity. Knockdown of KDM1B led to downregulation of DCLRE1B expression, suggesting that DCLRE1B was a KDM1B downstream target. Taken together, OD extract effectively promoted cell death in cisplatin-resistant ovarian cancer cells under cisplatin treatment through modulating KDM1B and DCLRE1B.

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Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell

Cited by 29 publications

References 34 publications

Suppression of YAP by DDP disrupts colon tumor progression

Suppression of YAP by DDP disrupts colon tumor progression

Scutellaria baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF‐κB Pathway in Cigarette Smoke Mediated‐COPD Rats Model

Promotion of Cell Death in Cisplatin-Resistant Ovarian Cancer Cells through KDM1B-DCLRE1B Modulation

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