2014
DOI: 10.1016/s1665-2681(19)30891-9
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Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds

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Cited by 139 publications
(60 citation statements)
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“…The anti-cancer activity of Spirulina was explained by its anti-proliferative effect observed on various cancer cell lines. The bioactivities found in Spirulina , for example, c-phycocianin and tetrapyrrolic compounds, exerted anti-proliferative effects in vitro on a myeloid leukemia cell line [33], but also on pancreatic cancer cell lines [17] and a hepatocellular carcinoma cell line [11]. Nonetheless, its influence on human colon cancer cell lines seems to be less thoroughly investigated [29].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The anti-cancer activity of Spirulina was explained by its anti-proliferative effect observed on various cancer cell lines. The bioactivities found in Spirulina , for example, c-phycocianin and tetrapyrrolic compounds, exerted anti-proliferative effects in vitro on a myeloid leukemia cell line [33], but also on pancreatic cancer cell lines [17] and a hepatocellular carcinoma cell line [11]. Nonetheless, its influence on human colon cancer cell lines seems to be less thoroughly investigated [29].…”
Section: Discussionmentioning
confidence: 99%
“…Obtained data strongly linked anti-cancer effects of S. platensis to its antioxidant activity. The in vitro studies showed that cytotoxic effect of Spirulina involved a decrease of proliferative capacity of tumorigenic cell lines that could result from mitochondrial activity disturbance [17]. Additionally, Ismail et al showed that S. platensis may induce apoptosis of the hepatocellular carcinoma cell line HepG2, increasing the Bax/Bcl-2 ratio [11].…”
Section: Introductionmentioning
confidence: 99%
“…Phycocyanobilin was observed to inhibit NADPH oxidase activity and reduce oxidative stress; down‐regulation of NADPH oxidase has a high potential in therapeutic and preventive medicine . Furthermore, extracts of spirulina have anti‐cancer activities attributed to phycocyanin, a protein with the phycocyanobilin chromophor as prosthetic group …”
Section: Beyond Chlorophyll Detoxification – Potential Bioactivities mentioning
confidence: 99%
“…Spirulina platensis (Sp) and its processing products are employed in agriculture, food industry, pharmaceutics, perfumery, and medicine (Hosseini, Khosravi‐Darani, & Mozafari, ). Indeed, Sp has several pharmacological activities such as antimicrobial, anticancer, metalloprotective (Konickova et al, ), as well as immunostimulant and antioxidant effects due to its rich content of protein, polysaccharide, lipid, essential amino and fatty acids, dietary minerals, and vitamins (Lupatini, Colla, Canan, & Colla, ). Recently, Sp supplementation at a dose of 1 g/d for 12 weeks was showed to be effective in modulating body weight and appetite and partly modifies serum lipids in obese individuals (Zeinalian, Farhangi, Shariat, & Saghafi‐Asl, ).…”
Section: Introductionmentioning
confidence: 99%