“… [ 50 ] Terminalia chebula Effective release comparison with extract in the gel. In vitro anti-arthritic activity demonstrates important anti-arthritic activity as opposed to normal Diclofenac activity [ 49 ] Paeonol Paeonol-loaded ethosomes showed improved transdermal absorption and skin retention (138.58 μg/cm 2 and 52.60 μg/cm 2 , respectively) [ 66 ] Figure 4 Possible vesicles to form phytosomes. Schematic representation of the different types of vesicles in phytochemical delivery, liposome, transfersome, niosome and ethosome.…”
Section: Vesicular Systems In Phytosome Developmentmentioning
Nowadays, medicinal herbs and their phytochemicals have emerged as a great therapeutic option for many disorders. However, poor bioavailability and selectivity might limit their clinical application. Therefore, bioavailability is considered a notable challenge to improve bio-efficacy in transporting dietary phytochemicals. Different methods have been proposed for generating effective carrier systems to enhance the bioavailability of phytochemicals. Among them, nano-vesicles have been introduced as promising candidates for the delivery of insoluble phytochemicals. Due to the easy preparation of the bilayer vesicles and their adaptability, they have been widely used and approved by the scientific literature. The first part of the review is focused on introducing phytosome technology as well as its applications, with emphasis on principles of formulations and characterization. The second part provides a wide overview of biological activities of commercial and non-commercial phytosomes, divided by systems and related pathologies. These results confirm the greater effectiveness of phytosomes, both in terms of biological activity or reduced dosage, highlighting curcumin and silymarin as the most formulated compounds. Finally, we describe the promising clinical and experimental findings regarding the applications of phytosomes. The conclusion of this study encourages the researchers to transfer their knowledge from laboratories to market, for a further development of these products.
“… [ 50 ] Terminalia chebula Effective release comparison with extract in the gel. In vitro anti-arthritic activity demonstrates important anti-arthritic activity as opposed to normal Diclofenac activity [ 49 ] Paeonol Paeonol-loaded ethosomes showed improved transdermal absorption and skin retention (138.58 μg/cm 2 and 52.60 μg/cm 2 , respectively) [ 66 ] Figure 4 Possible vesicles to form phytosomes. Schematic representation of the different types of vesicles in phytochemical delivery, liposome, transfersome, niosome and ethosome.…”
Section: Vesicular Systems In Phytosome Developmentmentioning
Nowadays, medicinal herbs and their phytochemicals have emerged as a great therapeutic option for many disorders. However, poor bioavailability and selectivity might limit their clinical application. Therefore, bioavailability is considered a notable challenge to improve bio-efficacy in transporting dietary phytochemicals. Different methods have been proposed for generating effective carrier systems to enhance the bioavailability of phytochemicals. Among them, nano-vesicles have been introduced as promising candidates for the delivery of insoluble phytochemicals. Due to the easy preparation of the bilayer vesicles and their adaptability, they have been widely used and approved by the scientific literature. The first part of the review is focused on introducing phytosome technology as well as its applications, with emphasis on principles of formulations and characterization. The second part provides a wide overview of biological activities of commercial and non-commercial phytosomes, divided by systems and related pathologies. These results confirm the greater effectiveness of phytosomes, both in terms of biological activity or reduced dosage, highlighting curcumin and silymarin as the most formulated compounds. Finally, we describe the promising clinical and experimental findings regarding the applications of phytosomes. The conclusion of this study encourages the researchers to transfer their knowledge from laboratories to market, for a further development of these products.
“…( 2016 ) and Harandi et al. ( 2018 ), the ethanolic extracts of senna seeds and pistachio pericarp exhibit anticancer properties.…”
Section: Resultsmentioning
confidence: 96%
“…This could be due to high concentrations of phenolic compounds, terpenes, and flavonoids present in the source plants (Fathalizadeh et al, 2015;Koyuncu et al, 2018). As reported by Ahmed et al (2016) and Harandi et al (2018), the ethanolic extracts of senna seeds and pistachio pericarp exhibit anticancer properties.…”
There is a growing interest in standardizing the biocompatible, cost‐effective, and eco‐friendly manufacturing techniques for metallic nanostructures due to their widespread applications in the industrial and medical sectors. In recent decades, green synthesis has been proven as the most suitable technique for synthesizing metal nanoparticles. The present research study investigates the use of Cassia angustifolia (senna) leaves and Pistacia vera (Pistachio) nuts to prepare crude aqueous extracts, ethanolic extracts, and biogenic silver nanoparticles (AgNPs). The prepared aqueous extracts were used as reducing, stabilizing, and capping agents for the production of silver nanoparticles. These AgNPs were characterized by scanning electron microscopy (SEM), Fourier‐transform infrared spectroscopy (FTIR), and ultraviolet–visible (UV–Vis) spectroscopy. The outcomes validated the formation of stable AgNPs with bioactive functional components. In vitro antibacterial, anticancer, anti‐inflammatory, and antioxidant potentials were assessed by Kirby–Bauer disk diffusion test, MIC test, MBC test, MTT assay, BSA denaturation inhibition assay, and DPPH antioxidant assay, respectively. Results confirmed that the tested plant extract possesses a variety of bioactive compounds with various biological activities and is therapeutically effective. These findings verified that C. angustifolia and P. vera are promising bioresources for the synthesis of therapeutic extracts and nanostructures with commendable therapeutic potency.
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