Anti-Cancer Effects of Oldenlandia diffusa extract on WiDr human colorectal adenocarcinoma cells

Lee, Soojin; Gim, Huijin; Shim, Ji Hwan; Park, Hyun Soo; Kim, Byung Joo

doi:10.14374/hfs.2015.23.1.101

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…[6] There are 171 known components of HDW , which have been reported to exert antitumor, immunomodulatory, anti-inflammatory, neuroprotective, and anti-fibrotic effects. [7] In Korea, there have been studies on the anticancer [8] and antiallergic effects [9] of HDW, while other studies conducted in China have shown that HDW can have significant effects in the prevention and treatment of acne, [10,11] and it is therefore also used clinically for acne diseases. Currently, clinical studies are being conducted in China to confirm the effect of HDW on acne.…”

Section: Introductionmentioning

confidence: 99%

Exploring the mechanism of action of Hedyotis diffusa Willd on acne using network analysis

Seo

Kim

2023

Medicine

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In this study, we used a network pharmacological method to explore the active ingredients of Hedyotis diffusa Willd (HDW) in the treatment of acne and elucidated the physiological mechanisms in the human body in which they are involved. We identified the active compounds of HDW that are expected to act effectively in the human body using the Traditional Chinese Medicine Systems Pharmacology database and analysis platform and extracted potential interacting proteins for each active compound using the Swiss Target Prediction platform. Next, we analyzed the potential mechanisms of action of the protein targets shared by HDW and each standard drug on acne and assessed the possibility of spontaneous occurrence of the binding between proteins and active compounds through the molecular docking process. Seven active compounds were selected according to the oral bioavailability and drug-likeness criteria of the Traditional Chinese Medicine Systems Pharmacology database and analysis platform. Subsequently, 300 protein targets were collected from the Swiss Target Prediction. Using the Search Tool for the Retrieval of Interacting Genes/Proteins database, a protein-protein interaction network was constructed by analyzing the relationship between HDW, acne, and each standard drug. By analyzing the gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathway, the "positive regulation of lipid metabolic process" was found to be the most involved pathway shared by HDW, acne, and isotretinoin. An analysis of the protein targets shared by the antibiotic agents with HDW and acne found that "cholesterol storage" in tetracycline, "icosacoid transport" in azithromycin, "steroid hydroxylase activity" in erythromycin, "positive regulation of leukocyte tethering or rolling" in clindamycin, "response to UV-A" in minocycline, "steroid 11-beta-monooxygenase activity" in doxycycline, and "neutrophil-mediated immunity" in trimethoprim were the most involved. Virtual molecular docking analysis showed that all proteins spontaneously bound to their corresponding active compounds. Our analysis suggests that HDW can, directly and indirectly, suppress sebum secretion and exert antiinflammatory effects on acne. Further, HDW may regulate free radicals and suppress apoptosis. Therefore, HDW can be used as an alternative or supplement to standard drugs for acne treatment in patients who cannot use standard treatments due to side effects.Abbreviations: BCL2 = B-cell lymphoma 2, COX-2 = cyclooxygenase 2, GO = gene ontology, HDW = Hedyotis diffusa Willd, IGF1R = insulin-like growth factor-1 receptor, IL = interleukin, KEGG = Kyoto Encyclopedia of Genes and Genomes, MMP = matrix metalloproteinase, NETs = neutrophil extravasation traps, NOS = nitric oxide synthase, NR1H = nuclear receptor subfamily 1 group H member, P. acnes = Propionibacterium acnes, PPAR = peroxisome proliferator-activated receptor, PPI = protein-protein interaction, PTGS2 = prostaglandin-endoperoxide synthase 2, ROS = reactive oxygen species, SMILE = simplified molecularinput-l...

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Section: Introductionmentioning

confidence: 99%

Exploring the mechanism of action of Hedyotis diffusa Willd on acne using network analysis

Seo

Kim

2023

Medicine

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Synergistic Effect of Natural Killer Cells and Bee Venom on Inhibition of NCI-H157 Cell Growth

Sung

Song

2016

The Acupuncture

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Anti-neoplastic and Anti-inflammatory Effects of Single and Mixed Extracts of Ulmus Davidiana and Oldenlandia Diffusa on Azoxymethane/dextran Sodium Sulfate-induced Colonic Neoplasms

Lee¹,

Dong-gi²,

Moon³

2017

J Int Korean Med

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Objectives : The purpose of this study was to investigate the anti-cancer effects of Oldenlandia diffusa extract on WiDr human colorectal adenocarcinoma cells.Methods : We examined cell death by (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) MTT assay and the caspase 3 and 9 activity assay with Oldenlandia diffusa extract. To examine the inhibitory effects of Oldenlandia diffusa extract, we performed a cell cycle (sub-G1) analysis and mitochondrial membrane potential for the WiDr cells after 24 hours with Oldenlandia diffusa extract.Results

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Anti-Cancer Effects of Oldenlandia diffusa extract on WiDr human colorectal adenocarcinoma cells

Cited by 3 publications

References 11 publications

Exploring the mechanism of action of Hedyotis diffusa Willd on acne using network analysis

Exploring the mechanism of action of Hedyotis diffusa Willd on acne using network analysis

Synergistic Effect of Natural Killer Cells and Bee Venom on Inhibition of NCI-H157 Cell Growth

Anti-neoplastic and Anti-inflammatory Effects of Single and Mixed Extracts of Ulmus Davidiana and Oldenlandia Diffusa on Azoxymethane/dextran Sodium Sulfate-induced Colonic Neoplasms

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