Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel

Current development of cabazitaxel drug delivery systems

“…Our group recently loaded cabazitaxel into PoP liposomes, in which the liposomes containing bilayer-anchored photosensitizer (porphyrin-phospholipid; PoP; Figure 3) (B. Sun et al, 2022). Both in vivo and in vitro experiments showed that MIA Paca-2 tumors were effectively killed or ablated while single CTX chemotherapy has less effective therapeutic effect.…”

“…Reproduced with permission fromZhao et al (2020) F I G U R E 3 Schematic illustration of CTX-PoP-lip liposome components. Reproduced with permission from B Sun et al (2022).…”

Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†

“…Several chemotherapeutic molecules have been encapsulated in PoP liposomes, which combined with the photoactivation of the porphyrin have been used for chemophototherapy. For example, cabazitaxel (149), doxorubicin (150) and irinotecan (151).…”

Oxygen Self-Supplied Perfluorocarbon-Modified Micelles for Enhanced Cancer Photodynamic Therapy and Ferroptosis

“…Photodynamic therapy (PDT) has emerged as a therapeutic tool for cancer treatment in recent years, offering high therapeutic selectivity, minimal systemic toxicity, and no drug resistance. − PDT has three components including photosensitizer, moderate laser light, and sufficient oxygen supply, and relies on the production of highly reactive singlet oxygen, which oxidizes biological macromolecules in the vicinity, ultimately causing cytotoxicity, damage, and potential cell death . However, the solid tumor site typically features hypoxic environments, impairing the therapeutic efficacy of PDT.…”