Anti-Cancer Mechanism and Possibility of Nano-Suspension Formulation for a Marine Algae Product Fucoxanthin

Abstract

Marine algae contain a wide variety of bioactive compounds; many of them have commercial applications in pharmaceutical, medical, cosmetic, nutraceutical, food and agricultural industries. Natural antioxidants, found in many algae play an important role against various diseases through protection of cells from oxidative AbstractRecently, use of natural products available from marine sources, and especially algae products, are receiving more attention. Scientific evidence for claimed nutraceutical and therapeutical effects of one such marine algae product, fucoxanthin, is discussed in this paper with a summary of the currently available literature regarding its antioxidant, anti-obesity and anticancer activities. It is safe for use in humans, but as it has poor solubility a nano-suspension mode of delivery may be adopted to improve efficacy of supplments. We conclude from ourliterature review that the marine algae product fucoxanthin has significant antioxidant, anti-obesity and anticancer activity with established mechanisms of action.

Fucoxanthin Elicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells

“…The main characteristic of an antioxidant is its ability to induce enzymes that trap free radicals (72). Although the biochemical process by which chemoprotective agents protect against cancers that are caused by oxidative stress has not been fully discovered, phase II detoxifying/antioxidant enzymes clearly play a role in fighting oxidative stress and preventing cancers (30).…”

In vitro and in vivo study of fucoxanthin bioavailability from nanoemulsion-based delivery systems: Impact of lipid carrier type

“…Fucoxanthin therefore has considerable potential as a nutraceutical ingredient that could be incorporated into functional food and beverage products. However, as with other carotenoids, there are a number of challenges that limit its potential application in foods, such as its low water-solubility, high melting point, and chemical instability (Hii, Choong, Woo, & Wong, 2010;Muthuirulappan & Francis, 2013). Food grade nanoemulsions, which consist of small lipid droplets (<100 nm) dispersed in water, may be a suitable strategy for incorporating carotenoids into foods and of enhancing their bioactivity profiles (McClements, 2011;.…”

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

“…It was also reported that herbal medicine was effective as potential therapy for fatty liver disease, diabetes, and metabolic syndrome [15]. Marine algae have also been shown to possess various biological activities such as antiasthmatic, antidiabetic, anticancer, and antioxidant effects [16,17,18]. However, insect-based bioactive products have rarely been studied, owing to a lack of scientific evidence regarding the safety and beneficial effects of insects despite their wide use as traditional foods or medicines in many countries.…”