Anti-Cancer Peptides

Sarafraz-Yazdi, Ehsan; Michl, Josef

doi:10.1007/978-3-642-27841-9_7132-3

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…Then the remaining solid matrix was filtered and rinsed with 0.5 mL ethanol and added to the extracted solution. The remaining was diluted with appropriate deionized water [21].…”

Section: Hair Samples Treatmentmentioning

confidence: 99%

Dispersive solid–liquid phase microextraction based on nanomagnetic Preyssler heteropolyacid: A novel method for the preconcentration of nortriptyline

Es’haghi

Hooshmand

2015

J of Separation Science

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In this study, a new, simple, rapid, and efficient method combined with ultraviolet visible spectrophotometry and high-performance liquid chromatography analysis was developed for the extraction and determination of nortriptyline. The tendency of the Preyssler tungsten heteropolyacid, H14 [NaP5 W30 O110 ], immobilized on the surface of mesoporous nanomagnetite to adsorb the drug from the solution has been investigated. This method involves the use of an appropriate mixture of nanosorbent that was homogenized in disperser solvent (1.0 mL, ethanol). At first, the mixture containing the nanomagnetic sorbent and disperser solvent was injected into the aqueous sample, and a cloudy solution was formed. Subsequently, separation of the two phases was carried out using a magnet. In the second stage, analyte was desorbed from the sorbent by methanol as the optimal desorption solvent using sonication method. The elution solvent containing enriched analyte was introduced to the instruments for further analysis. Optimization of experimental conditions with respect to the extraction efficiency was investigated. The method was linear in the range of 25-5000, while the detection limit (LOD = 3SB /m) was 7.9 ng/mL and the limit of quantification (LOQ = 10SB /m) was 26.4 ng/mL. The relative standard deviation was 4.66%. The method was successfully applied to human hair samples.

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“…Then the remaining solid matrix was filtered and rinsed with 0.5 mL ethanol and added to the extracted solution. The remaining was diluted with appropriate deionized water [21].…”

Section: Hair Samples Treatmentmentioning

confidence: 99%

Dispersive solid–liquid phase microextraction based on nanomagnetic Preyssler heteropolyacid: A novel method for the preconcentration of nortriptyline

Es’haghi

Hooshmand

2015

J of Separation Science

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“…In 1999, Pedersen-Bjergaard and Rasmussen introduced an hollow fiber (HF)-based liquid-phase microextraction (LPME) technique [10], which rapidly became the method of choice for miniaturized assays with a broad spectrum of applications, because of its unique characteristics such as low cost, easy operation, high enrichment factor, and its nearly solvent-free procedure. It has been demonstrated that LPME can be operated in different modes, such as liquid-liquid microextraction (LLME) [11], liquid-liquid-liquid microextraction [12], carrier mediated [13], and surfactant enhanced [14], etc. Several reviews have been devoted to the fundamental principles, historical development, and analytical applications [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Development of a novel 96-well format for liquid-liquid microextraction and its application in the HPLC analysis of biological samples

Borijihan

Gao

et al. 2014

J. Sep. Science

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A novel 96-well liquid-liquid microextraction system combined with modern HPLC was developed and used for the simultaneous analysis of 96 biological samples. The system made use of hollow fibers, a 96-well plate, and a plastic base with a center hole and a side hole. One end of the hollow fiber was sealed, while the other end was attached to one of the holes positioned at the center for the plastic base. The needle was inserted into the liquid from inside or outside of the hollow fiber through the center or the side holes, respectively. The system was tested with plasma samples containing three compounds, acidic indomethacin, neutral dexamethasone, and basic propafenone. Some parameters, such as the kind and dimension of hollow fiber, pH and salt concentration of the donor phase, the selection of organic solvent for the acceptor phase, and the extraction time were investigated. Under the optimization conditions, the Log D and drug concentration of indomethacin, dexamethasone, and propafenone in plasma and urine samples were analyzed. Then, the methodology was validated. The results demonstrated that ng/mL levels could be exactly and rapidly analyzed by our system, which was equipped with an auto-injection sampler, making sample analysis more convenient.

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“…Surfactants are amphiphilic molecules in which a polar or ionic group is connected to a long hydrocarbon tail (linear, branched, or containing aromatic rings) [24]. Surfactant-enhanced liquid-phase microextraction was investigated for extraction of basic drugs of abuse in hair [23]. Moradi et al reported a new strategy to simultaneous microextraction of acidic and basic compounds by using a cationic surfactant [25].…”

Section: Introductionmentioning

confidence: 99%

“…Hydrophobic analytes are easily extracted into the organic solvents from the donor aqueous phase, while hydrophilic and polar analytes have low solubility in the organic solvents; hence they are weakly extracted into the organic phase. In these situations, hollow‐fiber based LPME may be accomplished in carrier‐mediated, ion‐paired, or surfactant mode []. Surfactants are amphiphilic molecules in which a polar or ionic group is connected to a long hydrocarbon tail (linear, branched, or containing aromatic rings) [].…”

Section: Introductionmentioning

confidence: 99%

Optimization of ion‐pair based hollow fiber liquid phase microextraction combined with HPLC–UV for the determination of methimazole in biological samples and animal feed

Ebrahimzadeh

Asgharinezhad²,

Adlnasab³

et al. 2012

J of Separation Science

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Ion-pair based hollow fiber liquid phase microextraction (IP-HFLPME) coupled with high performance liquid chromatography-ultraviolet detection was applied for the preconcentration and determination of methimazole in biological samples and animal feed. Optimization of the conditions for the high extraction efficiency was studied simultaneously using the experimental design. For the first step, the Plackett-Burman design was applied to screen the significant factors on the extraction efficiency. Central composite design (CCD) was then used for the optimization of important factors and the response surface equations were obtained. The optimum experimental conditions were donor phase pH, 12.2; extraction temperature, 45°C; extraction time, 50 min; sodium perchlorate concentration, 1.5 M; cetyltrimethylammonium bromide concentration, 0.65 mM, and without salt addition in donor phase. The limit of detection and the dynamic linear range were in the range of 0.1-0.7 μg L(-1) and 0.5-1000 μg L(-1), respectively. Preconcentration factors were obtained in the range of 93-155 in different matrices. Finally, the performance of the proposed method was tested for the determination of trace amounts of methimazole in plasma, urine, bovine milk, and animal feed samples, and satisfactory results were obtained (RSDs < 7.1%).

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Anti-Cancer Peptides

Cited by 7 publications

References 5 publications

Dispersive solid–liquid phase microextraction based on nanomagnetic Preyssler heteropolyacid: A novel method for the preconcentration of nortriptyline

Dispersive solid–liquid phase microextraction based on nanomagnetic Preyssler heteropolyacid: A novel method for the preconcentration of nortriptyline

Development of a novel 96-well format for liquid-liquid microextraction and its application in the HPLC analysis of biological samples

Optimization of ion‐pair based hollow fiber liquid phase microextraction combined with HPLC–UV for the determination of methimazole in biological samples and animal feed

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