Anti-Cancer Properties of Flaxseed Proteome

Abstract

Flaxseed has been recognized as a valuable source of nutrients and bioactive compounds, including proteins that possess various health benefits. In recent years, studies have shown that flaxseed proteins, including albumins, globulins, glutelin, and prolamins, possess anti-cancer properties. These properties are attributed to their ability to inhibit cancer cell proliferation, induce apoptosis, and interfere with cancer cell signaling pathways, ultimately leading to the inhibition of metastasis. Moreover, flaxseed proteins have been reported to modulate cancer cell mechanobiology, leading to changes in cell behavior and reduced cancer cell migration and invasion. This review provides an overview of the anti-cancer properties of flaxseed proteins, with a focus on their potential use in cancer treatment. Additionally, it highlights the need for further research to fully establish the potential of flaxseed proteins in cancer therapy.

Proteomic Profile of Flaxseed (Linum usitatissimum L.) Products as Influenced by Protein Concentration Method and Cultivar

“…Flaxseed protein concentrate may be a good source of bioactive peptides having antibacterial, antioxidant, and antidiabetic effects as well as an angiotensin-converting enzyme inhibition effect due to the amino acid sequence of 11S globulin [15]. Merker et al [28] highlighted the potential of flaxseed proteins including 11S globulins to produce peptides with an anticarcinogenic effect.…”

“…According to other authors [3,25,28], these are polymeric proteins with MW ≈ 300 kDa. The PGs we have found have primary polypeptide sequences of 367-536 amino acids in length, from which two sub-polypeptide chains, an acidic and a basic one, are cut during post-translational processing, similarly to proteins of other oilseeds [40], which then give rise to the final monomer by their association via a disulfide bond.…”

“…Other important flaxseed proteins are reported to be the 7S storage protein, oleosins, late embryogenesis abundant (LEA) proteins and a number of metabolically important enzymes [1,26]. The importance of flaxseed proteins, especially 11S globulins and 2S albumins, in relation to food applications, human nutrition and medical applications has been sufficiently discussed in recent works [6,15,[26][27][28].…”