Anti-Cancer Properties of Heterotrigona itama sp. Honey Via Induction of Apoptosis in Malignant Glioma Cells

Ahmad, Fadzil; Seerangan, Priatharsine; Mustafa, Mohd Zulkifli; Osman, Zul Faizuddin; Abdullah, Jafri Malin; Idris, Zulkarnain Md

doi:10.21315/mjms2019.26.2.4

Cited by 32 publications

(22 citation statements)

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“…At the same time, the increased interest in honey is argued, in particular, by its therapeutic properties [11] [12] [13], including wound healing [14], treatment gastric ulcer [15], in preventing and combating cancer [16] [17] [18], and other. The anti-inflammatory properties of bee honey reduce the severity of lung manifestations in COVID-19 infections, which is quite important in the current context [19] [20] [21].…”

Section: Introductionmentioning

confidence: 99%

Physico-Chemical Profile of Four Types of Honey from the South of the Republic of Moldova

Chirsanova¹,

Capcanari²,

Boistean³

et al. 2021

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There are many studies that compare the quality and biological characteristics of honey with distinct geographical and botanical origins. However, the physico-chemical and biological properties of different types of honey in the same production regions are rarely mentioned. The honey used in this study: sunflower honey, rapeseed honey, manna honey and polyflora honey, came from GT "Malai C" in Taraclia village, Causeni district in the southern part of the Republic of Moldova and belonged to the flowering season of year 2020. Following the polynecological analysis, it was found that two types of honey are monofloral with a dominant pollen content of Helianthus spp. (49.15% -93.12%) in sunflower honey and Brassica spp. (52.17% -70.11%) in rapeseed honey. Mana honey and polyflora contain several types of pollen. Thus, four types were identified in manna honey, including: Acer platanoides (29.11% -30.11%), Quercus robur (28.67% -29.99%), Rubus idaeus (21.55% -28.78%), Taraxacum officinale (22.21% -28.76%). Polyflora honey contains: Helianthus annuus (24.91% -31.11%), Brassica napus (23.45% -29.18%), Tilia (28.95% -31.92%). Based on a Pfund scale, it was found that the color of the honey varied from a lighter shade for rapeseed honey (water amber 7.66 ± 3.002 mm) to a darker color for sunflower honey and polyflora (extra light amber 34.366 ± 21.01 mm and 36.04 ± 1.115 mm respectively). Spectrophotometric determination of phenolic compounds in honey samples showed that their content ranged from 38.18 mg GAE/kg honey for rapeseed honey to 831.09 mg GAE/kg honey for manna honey. At the same time, the flavonoid content ranged from 28.41 mg QUE/kg honey for rapeseed honey to 151.72 mg QUE/kg honey for manna honey. Mana honey showed a better antioxidant activity than the other honey samples in the study (72.03%). The reported results suggest that manna honey has the best potential and its consumption in the human diet as food with valuable biological properties can be How to cite this paper: Chirsanova, A.,

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Section: Introductionmentioning

confidence: 99%

Physico-Chemical Profile of Four Types of Honey from the South of the Republic of Moldova

Chirsanova¹,

Capcanari²,

Boistean³

et al. 2021

FNS

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“…By using cell proliferation and cells death assays, the authors demonstrated that SBH’s cytotoxic effect on this glioma cell line was time and dose-dependent. SBH also induced nuclear shrinkage, chromatin condensation and nucleus fragmentation, indicating that cellular changes were consistent with the apoptotic characteristics of the cells [ 33 ]. Taken together, these studies show exciting initial observations indicating that SBH may serve as a potential therapy for cancers and prompts the need for further investigation.…”

Section: Stingless Bee Honeymentioning

confidence: 99%

“…The results showed that SBH added to the culture media for three days resulted in a dose-dependent proliferative effect on DPSCs [ 35 ]. Another recent study by Ahmad et al has evaluated anticancer effects of SBH on malignant glioma (U-87) cells [ 33 ]. By using cell proliferation and cells death assays, the authors demonstrated that SBH’s cytotoxic effect on this glioma cell line was time and dose-dependent.…”

Section: Stingless Bee Honeymentioning

confidence: 99%

Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions

et al. 2020

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Stingless bees are a type of honey producers that commonly live in tropical countries. Their use for honey is being abandoned due to its limited production. However, the recent improvements in stingless bee honey production, particularly in South East Asia, have brought stingless bee products back into the picture. Although there are many stingless bee species that produce a wide spread of products, known since old eras in traditional medicine, the modern medical community is still missing more investigational studies on stingless bee products. Whereas comprehensive studies in the current era attest to the biological and medicinal properties of honeybee (Apis mellifera) products, the properties of stingless bee products are less known. This review highlights for the first time the medicinal benefits of stingless bee products (honey, propolis, pollen and cerumen), recent investigations and promising future directions. This review emphasizes the potential antioxidant properties of these products that in turn play a vital role in preventing and treating diseases associated with oxidative stress, microbial infections and inflammatory disorders. Summarizing all these data and insights in one manuscript may increase the commercial value of stingless bee products as a food ingredient. This review will also highlight the utility of stingless bee products in the context of medicinal and therapeutic properties, some of which are yet to be discovered.

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“…Glioma Cells, 2019 38 Esse trabalho demonstrou atividades anticâncer promissoras do mel de abelha sem ferrão da Malásia (Heterotrigona itama sp.) via inibição da proliferação de células e indução de apoptose precoce em linhagens de células de glioma maligno.…”

Section: Anti-cancer Properties Of Heterotrigona Itama Sp Honey Via Induction Of Apoptosis In Malignantunclassified

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2021

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Dentre as matérias primas extraídas da apicultura, o mel é considerado o produto mais fácil de ser explorado, sendo também aquele com maiores possibilidades de comercialização pois, além de ser um alimento, pode também ser utilizado na indústria farmacêutica e cosmética devido às suas conhecidas ações terapêuticas. Sabe-se que são diversas as propriedades medicinais dos méis, nesse sentido, essa revisão procurou avaliar a literatura científica da última década a respeito das propriedades biológicas associadas Brazilian Applied Science Review

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Anti-Cancer Properties of Heterotrigona itama sp. Honey Via Induction of Apoptosis in Malignant Glioma Cells

Cited by 32 publications

References 29 publications

Physico-Chemical Profile of Four Types of Honey from the South of the Republic of Moldova

Physico-Chemical Profile of Four Types of Honey from the South of the Republic of Moldova

Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions

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