Anti-cancer properties of quercetin in osteosarcoma

Abstract

Osteosarcoma is a primary bone tumor. Although it is a rare disease in general, it is the most common primary bone tumor among children. Despite the significant advances made in the field of osteosarcoma treatment, the outcomes of this disease are still unfavorable. Besides, there is still no targeted therapy for osteosarcoma that can be used in clinical settings. Quercetin is a member of the phytochemical family which is used for different diseases including cardiovascular diseases, diabetes, and cancer. Its anti-cancer effects are examined in many types of cancer including breast, colon, lung, prostate, and pancreatic cancers and have shown promising results. Herein, the studies dealing with the antitumor roles of quercetin in osteosarcoma are reviewed in this article. We take a look into quercetin’s ability to affect proliferation, apoptosis, invasion, and chemo-resistance of the osteosarcoma cells through regulating protein expression and signaling pathways.

Self-assembly behavior of thermoresponsive difunctionalized γ-amide polycaprolactone amphiphilic diblock copolymers

“…Que has been proven to have anticancer properties, and its bioavailability is limited by poor water solubility. 9,45–54 It is significant to develop drug carriers to improve the bioavailability of Que. The Que-loaded micelles were prepared by dialysis method in PBS (1×, pH = 7.4) first.…”

Pharmacological Activity of Quercetin: An Updated Review

“…Quercetin can influence the development of tumor by regulating epigenetics, which can directly regulate the expression of miRNA and the level of DNA methylation to exert an anticancer effect and enhance the sensitivity of tumor cells to chemotherapy [ 36 ]. Quercetin has a significant antitumor effect in osteosarcoma [ 40 ]. There is evidence that the possibility of using quercetin as a therapeutic option for glioblastoma multiforme [ 41 ].…”

Research Progress of Natural Small-Molecule Compounds Related to Tumor Differentiation

“…Quercetin is one of the main flavonoids. Some recent studies have shown that quercetin promotes osteoblast differentiation [ 90 , 91 , 92 , 93 ]. Moreover, several flavonoids, including icaritin [ 94 , 95 , 96 , 97 , 98 ], genistein [ 99 , 100 , 101 , 102 ] and kaempferol [ 103 , 104 , 105 ], have been shown to promote osteogenic differentiation by regulating the expression of Runx2 and BMP-2 differentiation through their estrogenic effects.…”