Anti-Cancer Role of Cassia alata Leaf Extract in a Rat Model of Lung Cancer

Mohamed, Sherif A.; Ibrahim, Mona G.; Soliman, Doaa

doi:10.21608/sjsci.2022.163110.1032

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…It is a fundamental medical shrub inside the Fabaceae family, Fabales order (Adedayo et al, 2001). C. alata contains a variety of bioactive chemical compounds, including phenolics (aloe emodin, glycosides, chrysaphanol, rhein and kaempferol,), fatty acids (oleic, palmitic, and linoleic acids), anthraquinones (alatinone and alatonal), steroids, and terpenoids (sitosterol, stigmasterol and campesterol) (Liu et al, 2009;Mohamed et al, 2023). These secondary metabolites have been manifested to have a wide variety of biological activities (Fernand et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Histological and ultrastructural studies on the effect of Cassia alata methanolic leaf extracts against chemically induced lung adenocarcinoma in rats

Fathalla,

Ibrahim,

Mohamed

et al. 2023

Arq. Bras. Med. Vet. Zootec.

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The present work aims to evaluate anticancer performance of Cassia alata methanolic leaf extracts (CMLE) in ethyl carbamate-stimulated lung adenocarcinoma (LAD) in differentiation to the function of Cisplatin (CIPL). Rats were divided into four groups: (1) control (CONT), (2) lung-adenocarcinoma (LAD) injected intra-peritoneally with 1g/kg ethyl carbamate once weekly for a month, (3) LAD+CMLE administered 500 mg/kg CMLE orally for the last two months of the experiment, and (4) LAD+CIPL treated group, injected 2.5 mg/kg Cisplatin intraperitoneally once weekly for the last two months of the experiment. Light and electron microscopic examinations revealed adenocarcinoma development in terminal bronchiole besides some histopathological changes in the LAD group such as atypical, exaggerated collagen fibers, increment of mucinous content, and increasing of PCNA positive immunoreactivity whereas electron microscopy investigation exposed that papillary adenocarcinoma originated from Clara cells in the LAD group. The LAD+CMLE treated group showed no tumor masses and nearly all with normal lung histology. It also recovered the normal ultrastructure of bronchiolar Clara cells. CMLE treatment offers a new alternative cure with less toxicity than Cisplatin for lung cancer therapy. Hence, CMLE would be employed as a novel supply of anti-cancer compounds combating lung cancer.

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Section: Introductionmentioning

confidence: 99%

Histological and ultrastructural studies on the effect of Cassia alata methanolic leaf extracts against chemically induced lung adenocarcinoma in rats

Fathalla,

Ibrahim,

Mohamed

et al. 2023

Arq. Bras. Med. Vet. Zootec.

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Review on Cassia alata Bioactive Compounds: In silico, in vitro, and in vivo Studies

Colin,

Claudiana,

Kaffah

et al. 2024

DDDT

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Cassia alata Linn is a popular herbal remedy in many countries, and its activities have been studied through many studies, starting from in silico, in vitro, and in vivo. This narrative review will focus more on secondary metabolites that are responsible for certain pharmacological activities that have undergone in vivo, in vitro, and in silico testing to determine the underlying mechanism. Twenty pharmacological activities have been identified, with the flavonoid group (emodin, kaempferol, quercetin) as the most prevalent secondary metabolite found in Cassia alata . There have been numerous studies looking at the role of flavonoids about specific diseases, and flavonoid testing is quite thorough because it covers three different study types. However, there has not been significant progress accomplished in terms of the evaluation of the dosage form so that test results for promising activities like antidiabetic, antifungal, and antiviral can be carried out into further research. Additionally, several disorders lack comprehensive investigation, particularly in silico studies, therefore further study is required to fill any gaps in the knowledge.

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Anti-Cancer Role of Cassia alata Leaf Extract in a Rat Model of Lung Cancer

Cited by 2 publications

References 44 publications

Histological and ultrastructural studies on the effect of Cassia alata methanolic leaf extracts against chemically induced lung adenocarcinoma in rats

Histological and ultrastructural studies on the effect of Cassia alata methanolic leaf extracts against chemically induced lung adenocarcinoma in rats

Review on Cassia alata Bioactive Compounds: In silico, in vitro, and in vivo Studies

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