Anti-cancerous effect of corn silk: a critical review on its mechanism of action and safety evaluation

Gulati, Amisha; Singh, Jyoti; Rasane, Prasad; Kaur, Sawinder; Kaur, Jaspreet; Nanda, Vikas

doi:10.1007/s13205-023-03673-1

Cited by 6 publications

(2 citation statements)

References 61 publications

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“…Antioxidants are helpful molecules that guard the body against radical species, entities that wreak havoc in certain biochemical pathways if left unattended. CS's antioxidant activity is hugely documented in the literature, with many authors acknowledging its potency [51][52][53][54].…”

Section: Total Antioxidant Capacitymentioning

confidence: 99%

Valorization of Corn Silk as an Agricultural By-Product through the Optimization of Ultrasound-Assisted Extraction

Mihali,

Frumuzachi,

Nicolescu

et al. 2024

Applied Sciences

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Corn silk, derived from the stigmas of corn (Zea mays, Poaceae) flowers, possesses valuable bioactive compounds that can be harnessed for therapeutical, nutritional, and industrial purposes. This research aimed to optimize the extraction of bioactive compounds from corn silk, specifically flavonoids and total antioxidant capacity, by comparing it with classical extraction (infusion and maceration). The study identified significant factors influencing total flavonoid content (TFC) and antioxidant activity (assessed through an ABTS assay), including ethanol concentration, ultrasonic amplitude, and their quadratic interactions. This optimized combination of independent variables (37.89% ethanolic concentration, 48.58% ultrasound amplitude, and an extraction time of 38.72 min) yielded a balanced extraction, maximizing both TFC and antioxidant activity. Further analyses revealed significant total phenolic content, total flavonoid content (50.69 ± 0.36 mg GAE, 23.54 ± 0.01 mg QE, and 78.33 ± 0.94 mg TE/g extract, respectively), and potent in vitro antioxidant activity, affirming the efficacy of the optimized extraction. The study also explored the inhibitory effects on α-glucosidase (IC50 = 411.67 ± 25.39 µg/mL), acetylcholinesterase (IC50 = 1166.4 ± 399.38 µg/mL), and pancreatic lipase (IC50 = 1519.67 ± 209.04 µg/mL), showcasing potential antidiabetic and neuroprotective properties. While tyrosinase inhibition activity was not observed, the research emphasizes the nutraceutical potential of corn silk, offering valuable insights for its utilization and further exploration in the pharmaceutical and functional food industries.

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Section: Total Antioxidant Capacitymentioning

confidence: 99%

Valorization of Corn Silk as an Agricultural By-Product through the Optimization of Ultrasound-Assisted Extraction

Mihali,

Frumuzachi,

Nicolescu

et al. 2024

Applied Sciences

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“…The anti-Alzheimer’s disease effect of corn silk is mainly reflected in the activity of phosphotransferase and the response to hormones [ 86 ]. Moreover, when talking about anti-cancer activity, compounds from corn silk may target the responses of immune cells, induce cytotoxicity, and upregulate the expression of pro-apoptotic genes p53, p21, caspase 9, and caspase 3 in certain cells like HeLa cervical cancer cells, MCF-7 breast cancer cells, PANC-02 pancreatic cancer cells, and Caco-2 colon cancer cells [ 92 ]. Moreover, corn silk extract could recover the amounts of sex hormones and sperm to normal conditions by reducing lipid peroxidation in male mice [ 93 ].…”

Section: Pharmacological Actionsmentioning

confidence: 99%

An Umbrella Insight into the Phytochemistry Features and Biological Activities of Corn Silk: A Narrative Review

Wang,

Mao,

Zhang

et al. 2024

Molecules

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Corn silk (Zea mays L.) is the stigma of an annual gramineous plant named corn, which is distributed in many regions worldwide and has a long history of medicinal use. In recent years, with the sustainable development of traditional Chinese medicine, studies of corn silk based on modern technologies, such as GC–MS, LC–MS, and other analytical means, have offered more comprehensive analyses. Phytochemistry studies have shown that the main bioactive components in corn silk include flavonoids, polyphenols, phenolic acids, fatty acids, and terpenoids. Pharmacological studies have shown that corn silk extract has various pharmacological effects, such as reducing blood lipids, lowering blood pressure, regulating blood sugar levels, anti-inflammatory effects, and anti-oxidation effects. In this paper, the related research on corn silk from the past few years is summarized to provide a theoretical reference for the further development and utilization of corn silk.

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Phytochemical study: Fragmentation patterns of flavonoid‐C‐glycosides in the enriched flavonoids from corn silk using high‐efficiency ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Wang,

Gu,

Mao

et al. 2023

Separation Science Plus

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Flavonoid‐C‐glycosides with various pharmacological actions were abundant in corn silk, and fragmentation in mass spectra of flavonoid‐C‐glycosides compounds was particularly important. This paper aimed to supervise the fragmentation patterns of flavonoid‐C‐glycosides in the enriched flavonoids from corn silk by high‐efficiency ultra‐high‐performance liquid chromatography combined with a quadrupole time‐of‐flight mass spectrometry approach. Therefore, the flavonoids were extracted by heating reflux and then purified based on D101 macroporous resin. Thirty‐five flavonoids were triumphantly identified in the purified product. Among them, 14 were flavonoid‐C‐glycosides, seven of them owned luteolin mother nuclei (luteolin‐C‐glycosides) and seven of them owned apigenin mother nuclei (apigenin‐C‐glycosides). Importantly, the diagnostic product ions of luteolin‐C‐glycosides including m/z (431, 413, 395, 369, 367, 313, and 299) and m/z (429, 411, 393, 367, 365, 311, and 297), and the characteristic product ions of apigenin‐C‐glycosides covered m/z (353, 339, and 299) and m/z (339, 327, and 309). In addition, diagnostic H2O neutral loss and glycosyl craking were familiar, and the difference values among product ions mainly contained 40, 60, 70, 80, 90, 100, and 120 Da. Thus, the fragmentations of luteolin‐C‐glycosides and apigenin‐C‐glycosides identified in corn silk were with proper regularity. The obtained fragmentation patterns provided rapid recognition and meaningful guidance for the purification study of flavonoid‐C‐glycosides.

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Anti-cancerous effect of corn silk: a critical review on its mechanism of action and safety evaluation

Cited by 6 publications

References 61 publications

Valorization of Corn Silk as an Agricultural By-Product through the Optimization of Ultrasound-Assisted Extraction

Valorization of Corn Silk as an Agricultural By-Product through the Optimization of Ultrasound-Assisted Extraction

An Umbrella Insight into the Phytochemistry Features and Biological Activities of Corn Silk: A Narrative Review

Phytochemical study: Fragmentation patterns of flavonoid‐C‐glycosides in the enriched flavonoids from corn silk using high‐efficiency ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

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