Anti-Candida activity of Quercus infectoria gall extracts against Candida species

Abstract

Background:Galls of Quercus infectoria have been traditionally used to treat common ailments, including yeast infections caused by Candida species.Objective:This study aimed to evaluate the in vitro anti-Candida activity of Q. infectoria gall extracts against selected Candida species.Materials and Methods:Methanol and aqueous extracts of Q. infectoria galls were tested for anti-Candida activity against Candida albicans, Candida krusei, Candida glabrata, Candida parapsilosis and Candida tropicalis. The minimum inhibitory concentrations were determined using the two-fold serial dilution technique of concentrations ranging from 16 mg/ml to 0.03 mg/ml. After 24 h, the minimum fungicidal concentrations were determined by subculturing the wells, which showed no turbidity on the agar plate. Potential phytochemical group in the crude extracts was screened by phytochemical qualitative tests and subsequently subjected to the gas chromatography-mass spectrometry analysis.Results:Both methanol and aqueous extracts displayed substantial anti-Candida activity and pyrogallol was the major component of both crude extracts.Conclusions:Data from current study suggested that Q. infectoria gall extracts are a potential source to be developed as anti-candidiasis.

Antimicrobial effects of Quercus infectoria gall extract on the cell morphology of Streptococcus agalactiae, Proteus vulgaris and Candida albicans

“…The results indicated that the QI gall methanolic extract was bactericidal or fungicidal against the tested microorganisms. Similar findings were obtained from previous studies performed on the QI gall methanolic extract tested against urogenital pathogens (Nur Saeida et al, 2014;Baharuddin et al, 2015). The QI gall extracts is well known to have broad spectrum antimicrobial activities.…”

“…High total tannin content in the QI gall extract suggests it may be responsible for the antimicrobial properties against several microorganisms (Darogha, 2009;Hassan, 2011). The source of QI galls used in this study were as those used in the previous studies (Nur Saeida et al, 2014;Baharuddin et al, 2015) and they have been tested phytochemically for the presence of major polyphenols namely 1,2,3-benzenetriol or pyrogallol. The hydroxyl groups and alpha-beta double bonds in the phenolic compound contributes to the activities of killing or inhibiting the microbial growth by interfering with the cell wall or cell membrane biosynthesis (Akiyama et al, 2001).…”

“…The QI gall extract is well known to have a broad spectrum of activity against Gram-positive bacteria, Gramnegative bacteria and yeast. The methanolic extract of the galls was reported to have higher potency in inhibiting the bacterial and Candida growth as compared to ethanol, water and other organic solvents extracts such as hexane and chloroform (Rao et al, 2013;Baharuddin et al, 2015). The inhibitory effect of the gall extract against microbial growth is generally dependent upon the structure of microbial cell wall.…”

Phytochemicals and Cytotoxicity of Quercus infectoria Ethyl Acetate Extracts on Human Cancer Cells

“…Studies indicated that QI galls have a variety of pharmacological properties including being an astringent (Dar et al 1976), antidiabetic (Kaur et al 2007), antitremorine local anesthetic, antiviral (Harborne 1986), potential antibacterial (Hwang et al 2000), antifungal (Baharuddin et al 2015;Magbool et al 2018), larvicidal (Ikram & Nowshad 1977) and anti-inflammation (Mc Clure 1975;Muhamad & Mustafa 1994). Various types of QI extracts were reported to poses anticancer activity on cervical cancer cells (Hasmah et al 2010) and colon cancer cells (Roshni & Ramesh 2013).…”

The Effect Of Giving The Rest Cleanser Of Manjakani Decoction Seeds (Quercus Infectoria Gall) Against Leucorrhoea Complaints On Hormonal Contraception Acceptors In The Work Area Of Puskesmas Sukajadi The City Of Bandung

“…17 One of the potential plants found in Indonesia is Manjakani seeds (Quercus infectory Gall). [17][18][19][20][21] The seeds have the same ability as other herbal ingredients, and even have a broader ability than some other herbal ingredients. They are popularly carried out to maintain the area of female sex organs and commonly used in dosage form capsules, powders, jelly, sticks or decoction.…”